Association between telomere length and atopic dermatitis among school‐age children
Abstract Background Atopic dermatitis is a common chronic skin disease in children. Whether telomere length is associated with atopic dermatitis remains unclear. This population‐based case‐control study aimed to investigate the association between telomere length and atopic dermatitis in school‐age...
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| Format: | Article |
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Wiley
2025-06-01
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| Series: | Clinical and Translational Allergy |
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| Online Access: | https://doi.org/10.1002/clt2.70066 |
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| author | Hsin‐Yi Huang Kun‐Hua Sheen Chi‐Yen Hung Ju Chang‐Chien Shih‐Ling Wang Chia‐Hua Ho Hui‐Ju Tsai Tsung‐Chieh Yao |
| author_facet | Hsin‐Yi Huang Kun‐Hua Sheen Chi‐Yen Hung Ju Chang‐Chien Shih‐Ling Wang Chia‐Hua Ho Hui‐Ju Tsai Tsung‐Chieh Yao |
| author_sort | Hsin‐Yi Huang |
| collection | DOAJ |
| description | Abstract Background Atopic dermatitis is a common chronic skin disease in children. Whether telomere length is associated with atopic dermatitis remains unclear. This population‐based case‐control study aimed to investigate the association between telomere length and atopic dermatitis in school‐age children. Methods In this cross‐sectional analysis, we included 1084 singleton term‐born children (608 males; mean age 6.4 years) from the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren cohort. Telomere length was measured using quantitative real‐time polymerase chain reaction, log‐transformed and was analyzed in quartiles. The main outcome was atopic dermatitis defined as having physician‐diagnosed atopic dermatitis and the presence of atopic dermatitis in the last 12 months. Regression analyses were used to assess the relationship between telomere length and atopic dermatitis. Results Telomere length was significantly inversely associated with childhood atopic dermatitis after adjusting for child's age, sex, overweight or obesity, birth season, childhood allergic diseases, environmental tobacco smoke, parental history of allergic diseases, parental educational level, and breastfeeding status (p_trend = 0.01). Specifically, when telomere length was classified into quartiles, children in the shortest (fourth) telomere length quartile had a 1.88‐fold higher probability of atopic dermatitis compared to those in the longest (first) quartile (95% confidence interval: 1.13–3.14). Stratified analyses showed that the associations were stronger in males and non‐breastfed children, with no significant associations observed in females or breastfed children. Conclusion This study provides new evidence suggesting an association between shorter telomere length and atopic dermatitis in school‐age children. |
| format | Article |
| id | doaj-art-5e5930ceea7a4250bb5b217b4a540fd4 |
| institution | Kabale University |
| issn | 2045-7022 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj-art-5e5930ceea7a4250bb5b217b4a540fd42025-08-20T03:27:52ZengWileyClinical and Translational Allergy2045-70222025-06-01156n/an/a10.1002/clt2.70066Association between telomere length and atopic dermatitis among school‐age childrenHsin‐Yi Huang0Kun‐Hua Sheen1Chi‐Yen Hung2Ju Chang‐Chien3Shih‐Ling Wang4Chia‐Hua Ho5Hui‐Ju Tsai6Tsung‐Chieh Yao7Division of Allergy, Asthma, and Rheumatology Department of Pediatrics Chang Gung Memorial Hospital Taoyuan TaiwanDepartment of Medical Science National Tsing Hua University Hsinchu TaiwanDepartment of Traditional Chinese Medicine Chang Gung Memorial Hospital Taoyuan TaiwanDivision of Allergy, Asthma, and Rheumatology Department of Pediatrics Chang Gung Memorial Hospital Taoyuan TaiwanDivision of Allergy, Asthma, and Rheumatology Department of Pediatrics Chang Gung Memorial Hospital Taoyuan TaiwanDepartment of Family Medicine Chang Gung Memorial Hospital Taoyuan TaiwanDepartment of Medical Science National Tsing Hua University Hsinchu TaiwanDivision of Allergy, Asthma, and Rheumatology Department of Pediatrics Chang Gung Memorial Hospital Taoyuan TaiwanAbstract Background Atopic dermatitis is a common chronic skin disease in children. Whether telomere length is associated with atopic dermatitis remains unclear. This population‐based case‐control study aimed to investigate the association between telomere length and atopic dermatitis in school‐age children. Methods In this cross‐sectional analysis, we included 1084 singleton term‐born children (608 males; mean age 6.4 years) from the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren cohort. Telomere length was measured using quantitative real‐time polymerase chain reaction, log‐transformed and was analyzed in quartiles. The main outcome was atopic dermatitis defined as having physician‐diagnosed atopic dermatitis and the presence of atopic dermatitis in the last 12 months. Regression analyses were used to assess the relationship between telomere length and atopic dermatitis. Results Telomere length was significantly inversely associated with childhood atopic dermatitis after adjusting for child's age, sex, overweight or obesity, birth season, childhood allergic diseases, environmental tobacco smoke, parental history of allergic diseases, parental educational level, and breastfeeding status (p_trend = 0.01). Specifically, when telomere length was classified into quartiles, children in the shortest (fourth) telomere length quartile had a 1.88‐fold higher probability of atopic dermatitis compared to those in the longest (first) quartile (95% confidence interval: 1.13–3.14). Stratified analyses showed that the associations were stronger in males and non‐breastfed children, with no significant associations observed in females or breastfed children. Conclusion This study provides new evidence suggesting an association between shorter telomere length and atopic dermatitis in school‐age children.https://doi.org/10.1002/clt2.70066atopic dermatitischildrentelomere length |
| spellingShingle | Hsin‐Yi Huang Kun‐Hua Sheen Chi‐Yen Hung Ju Chang‐Chien Shih‐Ling Wang Chia‐Hua Ho Hui‐Ju Tsai Tsung‐Chieh Yao Association between telomere length and atopic dermatitis among school‐age children Clinical and Translational Allergy atopic dermatitis children telomere length |
| title | Association between telomere length and atopic dermatitis among school‐age children |
| title_full | Association between telomere length and atopic dermatitis among school‐age children |
| title_fullStr | Association between telomere length and atopic dermatitis among school‐age children |
| title_full_unstemmed | Association between telomere length and atopic dermatitis among school‐age children |
| title_short | Association between telomere length and atopic dermatitis among school‐age children |
| title_sort | association between telomere length and atopic dermatitis among school age children |
| topic | atopic dermatitis children telomere length |
| url | https://doi.org/10.1002/clt2.70066 |
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