Association between weight-adjusted-waist index and serum anti-aging protein α-Klotho in U.S. adults: Evidence from NHANES 2007–2016
Background: As unhealthy diets have proliferated, there has been an increasing trend in the prevalence of obesity along with socioeconomic progress. WWI, mainly representing weight-independent central obesity, is a more accurate indicator of obesity than BMI and WC. Klotho is known to be one of the...
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Elsevier
2025-02-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556524003188 |
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| author | Zujun Wen Xiang Liu Tingting Zhang Junhai Zhang Zhicong Zou Shuncheng Jiang Shusi Li |
| author_facet | Zujun Wen Xiang Liu Tingting Zhang Junhai Zhang Zhicong Zou Shuncheng Jiang Shusi Li |
| author_sort | Zujun Wen |
| collection | DOAJ |
| description | Background: As unhealthy diets have proliferated, there has been an increasing trend in the prevalence of obesity along with socioeconomic progress. WWI, mainly representing weight-independent central obesity, is a more accurate indicator of obesity than BMI and WC. Klotho is known to be one of the root causes of several age-related illnesses. There has never been any prior evidence associating WWI and serum α-Klotho levels. Methods: The current cross-sectional investigation used data from the National Health and Nutrition Examination Survey (NHANES) 2013–2016. The calculation of each participant's WWI involved dividing their waist circumference in centimeters by the square root of their weight in kilograms. Using multivariable linear regression models, the association between serum Klotho concentrations and WWI was analyzed. Smoothed curve fitting was utilized to investigate the nonlinear connection. In addition, interaction tests and other subgroup analyses were carried out. Results: With an average age of 57.57 ± 10.81 years, 13,172 participants were enrolled in this study, of whom 51.45 % were female. After full adjustment, each unit increase in WWI was significantly associated with a decrease in Klotho by 23.18 ng/ml [β(95%CI) = −23.18 (−31.34, −15.02)]. Moreover, we uncovered that WWI had a stronger negative correlation with Klotho than other obesity markers, such as WC, body mass index (BMI), and a body shape index (ABSI). Conclusions: To sum up, weight-adjusted-waist index levels were negatively associated with serum Klotho protein concentration and showed a stronger correlation than other obesity markers. Our findings indicated that WWI may be a predictor of reduced Klotho levels, and that controlling obesity in accordance with WWI may help lower the Klotho levels. |
| format | Article |
| id | doaj-art-5e555c7a21e448a2bbc52444415fb7f2 |
| institution | Kabale University |
| issn | 1873-6815 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj-art-5e555c7a21e448a2bbc52444415fb7f22025-01-31T05:10:07ZengElsevierExperimental Gerontology1873-68152025-02-01200112672Association between weight-adjusted-waist index and serum anti-aging protein α-Klotho in U.S. adults: Evidence from NHANES 2007–2016Zujun Wen0Xiang Liu1Tingting Zhang2Junhai Zhang3Zhicong Zou4Shuncheng Jiang5Shusi Li6Department of pharmacy, Heyuan People's Hospital, Heyuan, China; Corresponding author.The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, ChinaDepartment of pharmacy, Heyuan People's Hospital, Heyuan, ChinaDepartment of burns and plastic surgery, Heyuan People's Hospital, Heyuan, ChinaDepartment of pharmacy, Heyuan People's Hospital, Heyuan, ChinaDepartment of pharmacy, Heyuan People's Hospital, Heyuan, ChinaDepartment of pharmacy, Heyuan People's Hospital, Heyuan, ChinaBackground: As unhealthy diets have proliferated, there has been an increasing trend in the prevalence of obesity along with socioeconomic progress. WWI, mainly representing weight-independent central obesity, is a more accurate indicator of obesity than BMI and WC. Klotho is known to be one of the root causes of several age-related illnesses. There has never been any prior evidence associating WWI and serum α-Klotho levels. Methods: The current cross-sectional investigation used data from the National Health and Nutrition Examination Survey (NHANES) 2013–2016. The calculation of each participant's WWI involved dividing their waist circumference in centimeters by the square root of their weight in kilograms. Using multivariable linear regression models, the association between serum Klotho concentrations and WWI was analyzed. Smoothed curve fitting was utilized to investigate the nonlinear connection. In addition, interaction tests and other subgroup analyses were carried out. Results: With an average age of 57.57 ± 10.81 years, 13,172 participants were enrolled in this study, of whom 51.45 % were female. After full adjustment, each unit increase in WWI was significantly associated with a decrease in Klotho by 23.18 ng/ml [β(95%CI) = −23.18 (−31.34, −15.02)]. Moreover, we uncovered that WWI had a stronger negative correlation with Klotho than other obesity markers, such as WC, body mass index (BMI), and a body shape index (ABSI). Conclusions: To sum up, weight-adjusted-waist index levels were negatively associated with serum Klotho protein concentration and showed a stronger correlation than other obesity markers. Our findings indicated that WWI may be a predictor of reduced Klotho levels, and that controlling obesity in accordance with WWI may help lower the Klotho levels.http://www.sciencedirect.com/science/article/pii/S0531556524003188AgingWeight-adjusted-waist indexα-KlothoProspective cohort studyNHANES |
| spellingShingle | Zujun Wen Xiang Liu Tingting Zhang Junhai Zhang Zhicong Zou Shuncheng Jiang Shusi Li Association between weight-adjusted-waist index and serum anti-aging protein α-Klotho in U.S. adults: Evidence from NHANES 2007–2016 Experimental Gerontology Aging Weight-adjusted-waist index α-Klotho Prospective cohort study NHANES |
| title | Association between weight-adjusted-waist index and serum anti-aging protein α-Klotho in U.S. adults: Evidence from NHANES 2007–2016 |
| title_full | Association between weight-adjusted-waist index and serum anti-aging protein α-Klotho in U.S. adults: Evidence from NHANES 2007–2016 |
| title_fullStr | Association between weight-adjusted-waist index and serum anti-aging protein α-Klotho in U.S. adults: Evidence from NHANES 2007–2016 |
| title_full_unstemmed | Association between weight-adjusted-waist index and serum anti-aging protein α-Klotho in U.S. adults: Evidence from NHANES 2007–2016 |
| title_short | Association between weight-adjusted-waist index and serum anti-aging protein α-Klotho in U.S. adults: Evidence from NHANES 2007–2016 |
| title_sort | association between weight adjusted waist index and serum anti aging protein α klotho in u s adults evidence from nhanes 2007 2016 |
| topic | Aging Weight-adjusted-waist index α-Klotho Prospective cohort study NHANES |
| url | http://www.sciencedirect.com/science/article/pii/S0531556524003188 |
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