Long-term non-conditional and conditional metastasis of uveal melanoma by tumor size category in 8034 patients
Purpose: To estimate metastasis of patients with uveal melanoma (UM) based on tumor size categories classified by ultrasonographic thickness as small (0.0–3.0 mm), medium (3.1–8.0 mm), or large (≥8.1 mm) using both non-conditional and conditional analyses. Design: Retrospective analysis. Methods: A...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_2453_24 |
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| author | Rolika Bansal Hidayet Sener Jerry A Shields Carol L Shields |
| author_facet | Rolika Bansal Hidayet Sener Jerry A Shields Carol L Shields |
| author_sort | Rolika Bansal |
| collection | DOAJ |
| description | Purpose:
To estimate metastasis of patients with uveal melanoma (UM) based on tumor size categories classified by ultrasonographic thickness as small (0.0–3.0 mm), medium (3.1–8.0 mm), or large (≥8.1 mm) using both non-conditional and conditional analyses.
Design:
Retrospective analysis.
Methods:
A retrospective study of 8034 cases over 35-years at a single ocular oncology referral center evaluated the primary endpoint of cumulative incidence of metastasis at 5-, 10-, 15-, 20-, 25- and 30-years using non-conditional and conditional analysis at 3-years, 5-years, and 10-years of metastasis-free survival.
Results:
The mean thicknesses for small, medium, and large UMs were 2.5 mm, 5.0 mm, and 10.2 mm, respectively. Based on tumor size category (small vs. medium vs. large), the 25-year non-conditional metastasis was 5% vs. 12% vs. 21%, and for those with 3-year metastasis-free survival, the 25-year incidence of metastasis was 7% vs. 13% vs. 26%. For those with 5-year metastasis-free survival, the 25-year incidence of metastasis was 6% vs. 11% vs. 21%. For those with 10-year metastasis-free survival, the 25-year incidence of metastasis was 4% vs. 8% vs. 21%. For small vs. medium UM, by conditional analysis, those who maintained 3-year/5-year/10-year metastasis-free survival, hazard ratio was 1.50 (P <0.01)/1.53 (P <0.01)/1.77 (P = 0.01), and for medium vs. large UM, hazard ratio was 1.45 (P <0.01)/1.44 (P = 0.03)/1.96 (P = 0.06).
Conclusion:
Long-term comparative analysis of UM metastasis, based on tumor size category (thickness) as small, medium, or large, revealed that large UM is more likely with higher tendency to develop metastasis over time. The patients achieving 3-, 5-, and 10-year metastasis-free survival demonstrated significantly reduced subsequent risk of metastasis across all tumor size categories. |
| format | Article |
| id | doaj-art-5e527665ec1448d3a014cd43e13de298 |
| institution | Kabale University |
| issn | 0301-4738 1998-3689 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj-art-5e527665ec1448d3a014cd43e13de2982025-08-20T03:29:45ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892025-06-0173689389910.4103/IJO.IJO_2453_24Long-term non-conditional and conditional metastasis of uveal melanoma by tumor size category in 8034 patientsRolika BansalHidayet SenerJerry A ShieldsCarol L ShieldsPurpose: To estimate metastasis of patients with uveal melanoma (UM) based on tumor size categories classified by ultrasonographic thickness as small (0.0–3.0 mm), medium (3.1–8.0 mm), or large (≥8.1 mm) using both non-conditional and conditional analyses. Design: Retrospective analysis. Methods: A retrospective study of 8034 cases over 35-years at a single ocular oncology referral center evaluated the primary endpoint of cumulative incidence of metastasis at 5-, 10-, 15-, 20-, 25- and 30-years using non-conditional and conditional analysis at 3-years, 5-years, and 10-years of metastasis-free survival. Results: The mean thicknesses for small, medium, and large UMs were 2.5 mm, 5.0 mm, and 10.2 mm, respectively. Based on tumor size category (small vs. medium vs. large), the 25-year non-conditional metastasis was 5% vs. 12% vs. 21%, and for those with 3-year metastasis-free survival, the 25-year incidence of metastasis was 7% vs. 13% vs. 26%. For those with 5-year metastasis-free survival, the 25-year incidence of metastasis was 6% vs. 11% vs. 21%. For those with 10-year metastasis-free survival, the 25-year incidence of metastasis was 4% vs. 8% vs. 21%. For small vs. medium UM, by conditional analysis, those who maintained 3-year/5-year/10-year metastasis-free survival, hazard ratio was 1.50 (P <0.01)/1.53 (P <0.01)/1.77 (P = 0.01), and for medium vs. large UM, hazard ratio was 1.45 (P <0.01)/1.44 (P = 0.03)/1.96 (P = 0.06). Conclusion: Long-term comparative analysis of UM metastasis, based on tumor size category (thickness) as small, medium, or large, revealed that large UM is more likely with higher tendency to develop metastasis over time. The patients achieving 3-, 5-, and 10-year metastasis-free survival demonstrated significantly reduced subsequent risk of metastasis across all tumor size categories.https://journals.lww.com/10.4103/IJO.IJO_2453_24conditional survivalmetastasisnon-conditional survivaltumor size categoryuveal melanoma |
| spellingShingle | Rolika Bansal Hidayet Sener Jerry A Shields Carol L Shields Long-term non-conditional and conditional metastasis of uveal melanoma by tumor size category in 8034 patients Indian Journal of Ophthalmology conditional survival metastasis non-conditional survival tumor size category uveal melanoma |
| title | Long-term non-conditional and conditional metastasis of uveal melanoma by tumor size category in 8034 patients |
| title_full | Long-term non-conditional and conditional metastasis of uveal melanoma by tumor size category in 8034 patients |
| title_fullStr | Long-term non-conditional and conditional metastasis of uveal melanoma by tumor size category in 8034 patients |
| title_full_unstemmed | Long-term non-conditional and conditional metastasis of uveal melanoma by tumor size category in 8034 patients |
| title_short | Long-term non-conditional and conditional metastasis of uveal melanoma by tumor size category in 8034 patients |
| title_sort | long term non conditional and conditional metastasis of uveal melanoma by tumor size category in 8034 patients |
| topic | conditional survival metastasis non-conditional survival tumor size category uveal melanoma |
| url | https://journals.lww.com/10.4103/IJO.IJO_2453_24 |
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