Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice.
Major depression is becoming one of the most prevalent forms of psychiatric disorders. However, the mechanisms of major depression are still not well-understood. Most antidepressants are only effective in some patients and produce some serious side effects. Animal models of depression are therefore...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093640&type=printable |
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| _version_ | 1850189878761881600 |
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| author | Liyan Ren Xuanchen Qian Lijing Zhai Miao Sun Zhigang Miao Jizhen Li Xingshun Xu |
| author_facet | Liyan Ren Xuanchen Qian Lijing Zhai Miao Sun Zhigang Miao Jizhen Li Xingshun Xu |
| author_sort | Liyan Ren |
| collection | DOAJ |
| description | Major depression is becoming one of the most prevalent forms of psychiatric disorders. However, the mechanisms of major depression are still not well-understood. Most antidepressants are only effective in some patients and produce some serious side effects. Animal models of depression are therefore essential to unravel the mechanisms of depression and to develop novel therapeutic strategies. Our previous studies showed that Abelson helper integration site-1 (Ahi1) deficiency causes depression-like behaviors in mice. In this study, we characterized the biochemical and behavioral changes in Ahi1 knockout (KO) mice. In Ahi1 KO mice, neurotransmitters including serotonin and dopamine were significantly decreased in different brain regions. However, glutamate and GABA levels were not affected by Ahi1 deficiency. The antidepressant imipramine attenuated depressive behaviors and partially restored brain serotonin level in Ahi1 KO mice. Our findings suggest that Ahi1 KO mice can be used for studying the mechanisms of depression and screening therapeutic targets. |
| format | Article |
| id | doaj-art-5e524917c6044d3e80716e328a22ce87 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-5e524917c6044d3e80716e328a22ce872025-08-20T02:15:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9364010.1371/journal.pone.0093640Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice.Liyan RenXuanchen QianLijing ZhaiMiao SunZhigang MiaoJizhen LiXingshun XuMajor depression is becoming one of the most prevalent forms of psychiatric disorders. However, the mechanisms of major depression are still not well-understood. Most antidepressants are only effective in some patients and produce some serious side effects. Animal models of depression are therefore essential to unravel the mechanisms of depression and to develop novel therapeutic strategies. Our previous studies showed that Abelson helper integration site-1 (Ahi1) deficiency causes depression-like behaviors in mice. In this study, we characterized the biochemical and behavioral changes in Ahi1 knockout (KO) mice. In Ahi1 KO mice, neurotransmitters including serotonin and dopamine were significantly decreased in different brain regions. However, glutamate and GABA levels were not affected by Ahi1 deficiency. The antidepressant imipramine attenuated depressive behaviors and partially restored brain serotonin level in Ahi1 KO mice. Our findings suggest that Ahi1 KO mice can be used for studying the mechanisms of depression and screening therapeutic targets.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093640&type=printable |
| spellingShingle | Liyan Ren Xuanchen Qian Lijing Zhai Miao Sun Zhigang Miao Jizhen Li Xingshun Xu Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice. PLoS ONE |
| title | Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice. |
| title_full | Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice. |
| title_fullStr | Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice. |
| title_full_unstemmed | Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice. |
| title_short | Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice. |
| title_sort | loss of ahi1 impairs neurotransmitter release and causes depressive behaviors in mice |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093640&type=printable |
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