Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
Abstract Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex interplay of several pathways, including inflammation, immune activation, hypoxia, and metabolic reprogramming. Specifically, the regulation and the impact of the latter have become better understood in w...
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| Format: | Article |
| Language: | English |
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Springer Nature
2018-07-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.201708712 |
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| author | Lise Van Wyngene Jolien Vandewalle Claude Libert |
| author_facet | Lise Van Wyngene Jolien Vandewalle Claude Libert |
| author_sort | Lise Van Wyngene |
| collection | DOAJ |
| description | Abstract Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex interplay of several pathways, including inflammation, immune activation, hypoxia, and metabolic reprogramming. Specifically, the regulation and the impact of the latter have become better understood in which the highly catabolic status during sepsis and its similarity with starvation responses appear to be essential in the poor prognosis in sepsis. It seems logical that new interventions based on the recognition of new therapeutic targets in the key metabolic pathways should be developed and may have a good chance to penetrate to the bedside. In this review, we concentrate on the pathological changes in metabolism, observed during sepsis, and the presumed underlying mechanisms, with a focus on the level of the organism and the interplay between different organ systems. |
| format | Article |
| id | doaj-art-5e5202d300ce4e74bcbb10b68de2cf66 |
| institution | DOAJ |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2018-07-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-5e5202d300ce4e74bcbb10b68de2cf662025-08-20T03:05:55ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842018-07-0110811810.15252/emmm.201708712Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?Lise Van Wyngene0Jolien Vandewalle1Claude Libert2Center for Inflammation Research, VIBCenter for Inflammation Research, VIBCenter for Inflammation Research, VIBAbstract Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex interplay of several pathways, including inflammation, immune activation, hypoxia, and metabolic reprogramming. Specifically, the regulation and the impact of the latter have become better understood in which the highly catabolic status during sepsis and its similarity with starvation responses appear to be essential in the poor prognosis in sepsis. It seems logical that new interventions based on the recognition of new therapeutic targets in the key metabolic pathways should be developed and may have a good chance to penetrate to the bedside. In this review, we concentrate on the pathological changes in metabolism, observed during sepsis, and the presumed underlying mechanisms, with a focus on the level of the organism and the interplay between different organ systems.https://doi.org/10.15252/emmm.201708712hypoxiainflammationinterventionsmetabolic reprogrammingsepsis |
| spellingShingle | Lise Van Wyngene Jolien Vandewalle Claude Libert Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? EMBO Molecular Medicine hypoxia inflammation interventions metabolic reprogramming sepsis |
| title | Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? |
| title_full | Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? |
| title_fullStr | Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? |
| title_full_unstemmed | Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? |
| title_short | Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? |
| title_sort | reprogramming of basic metabolic pathways in microbial sepsis therapeutic targets at last |
| topic | hypoxia inflammation interventions metabolic reprogramming sepsis |
| url | https://doi.org/10.15252/emmm.201708712 |
| work_keys_str_mv | AT lisevanwyngene reprogrammingofbasicmetabolicpathwaysinmicrobialsepsistherapeutictargetsatlast AT jolienvandewalle reprogrammingofbasicmetabolicpathwaysinmicrobialsepsistherapeutictargetsatlast AT claudelibert reprogrammingofbasicmetabolicpathwaysinmicrobialsepsistherapeutictargetsatlast |