Reduced functional independence and multimorbidity increases the risk of severe infection among older patients with Omicron: a multicenter retrospective cohort study
Abstract Background Multimorbidity and physical function in older adults have been identified as associated with coronavirus disease 2019 (COVID-19) outcomes. This study aimed to investigate whether multimorbidity affects the association of impaired functional independence (FI) with critical COVID-1...
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BMC
2025-02-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-025-05739-6 |
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| author | Wan Yu Runnian Huang Shuning Sun Li Bu Xin Chen Yunhua Di Shuwu Lin Qian Li Yang Yang Xingyue Ye Wenxu Wang Rui Ren Linze Xi Ru Zhang Yi Li Xin Li Tianbo Hou Zibo Ning Yang Peng Difei Wang |
| author_facet | Wan Yu Runnian Huang Shuning Sun Li Bu Xin Chen Yunhua Di Shuwu Lin Qian Li Yang Yang Xingyue Ye Wenxu Wang Rui Ren Linze Xi Ru Zhang Yi Li Xin Li Tianbo Hou Zibo Ning Yang Peng Difei Wang |
| author_sort | Wan Yu |
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| description | Abstract Background Multimorbidity and physical function in older adults have been identified as associated with coronavirus disease 2019 (COVID-19) outcomes. This study aimed to investigate whether multimorbidity affects the association of impaired functional independence (FI) with critical COVID-19 among older inpatients during the peak of Omicron infection in China. Methods This is a multicentre, retrospective cohort study in northeastern China. Patients aged ≥ 60 years, who were diagnosed with COVID-19 at the time of admission or during hospitalisation. The Barthel index was used to assess FI. Patients were classified into independent, mildly dependent, moderately dependent, and severely dependent groups. Disease severity was classified as critical, severe, and non-severe and combined into severe or critical and non-severe. Binary logistic regression analysis was used to investigate any correlation between FI and disease severity. Patients were further stratified by presence or absence of multimorbidity. Findings In this study, of 1598 patients, 530 (33.17%) developed severe or critical infections during the entire hospital stay. Patients with severe dependency had 7.39 times (95% CI: [4.60, 12.15]) higher risk of serious or critical infections than those without dependency. An interaction was noted between reduced FI and multimorbidity (p for interaction < 0.001). Compared to non-multimorbid patients (OR = 3.71, 95% CI: [1.58, 9.16]), multimorbid patients (OR = 10.04, 95% CI: [5.63, 18.57]) had a more pronounced risk of severe or critical infection. Conclusions Our results provide further scientific evidence on the association between FI, multimorbidity, and disease severity in older COVID-19 patients, contributing to future health decision-making for COVID-19 and other infectious diseases. |
| format | Article |
| id | doaj-art-5e4e2e6af3d741d0b7c0d35244c64b1a |
| institution | Kabale University |
| issn | 1471-2318 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Geriatrics |
| spelling | doaj-art-5e4e2e6af3d741d0b7c0d35244c64b1a2025-02-09T12:53:30ZengBMCBMC Geriatrics1471-23182025-02-0125111110.1186/s12877-025-05739-6Reduced functional independence and multimorbidity increases the risk of severe infection among older patients with Omicron: a multicenter retrospective cohort studyWan Yu0Runnian Huang1Shuning Sun2Li Bu3Xin Chen4Yunhua Di5Shuwu Lin6Qian Li7Yang Yang8Xingyue Ye9Wenxu Wang10Rui Ren11Linze Xi12Ru Zhang13Yi Li14Xin Li15Tianbo Hou16Zibo Ning17Yang Peng18Difei Wang19Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical UniversityBeijing Institute for Brain Disorders, Capital Medical UniversityDepartment of Neurology, Liaoning Jinqiu HospitalDepartment of Geriatric Respiratory Medicine, Liaoning Jinqiu HospitalDepartment of Internal Medicine, Geriatric Center, The Fourth People’s Hospital of Shenyang, China Medical UniversityDepartment of Endocrinology and Metabolism, Central Hospital Affiliated to Shenyang Medical CollegeDepartment of Geriatrics, The Second Affiliated Hospital of Shenyang Medical CollegeDepartment of Internal Medicine, Geriatric Center, The Fourth People’s Hospital of Shenyang, China Medical UniversityThe Second Affiliated Hospital of Shenyang Medical CollegeDepartment of Health Statistics, School of Public Health, China Medical UniversityDepartment of Health Statistics, School of Public Health, China Medical UniversityDepartment of Health Statistics, School of Public Health, China Medical UniversityDepartment of Health Statistics, School of Public Health, China Medical UniversityDepartment of Health Statistics, School of Public Health, China Medical UniversityDepartment of Health Statistics, School of Public Health, China Medical UniversityDepartment of Health Statistics, School of Public Health, China Medical UniversityDepartment of Health Statistics, School of Public Health, China Medical UniversityDepartment of Health Statistics, School of Public Health, China Medical UniversityDepartment of Gerontology and Geriatrics, Shengjing Hospital of China Medical UniversityDepartment of Gerontology and Geriatrics, Shengjing Hospital of China Medical UniversityAbstract Background Multimorbidity and physical function in older adults have been identified as associated with coronavirus disease 2019 (COVID-19) outcomes. This study aimed to investigate whether multimorbidity affects the association of impaired functional independence (FI) with critical COVID-19 among older inpatients during the peak of Omicron infection in China. Methods This is a multicentre, retrospective cohort study in northeastern China. Patients aged ≥ 60 years, who were diagnosed with COVID-19 at the time of admission or during hospitalisation. The Barthel index was used to assess FI. Patients were classified into independent, mildly dependent, moderately dependent, and severely dependent groups. Disease severity was classified as critical, severe, and non-severe and combined into severe or critical and non-severe. Binary logistic regression analysis was used to investigate any correlation between FI and disease severity. Patients were further stratified by presence or absence of multimorbidity. Findings In this study, of 1598 patients, 530 (33.17%) developed severe or critical infections during the entire hospital stay. Patients with severe dependency had 7.39 times (95% CI: [4.60, 12.15]) higher risk of serious or critical infections than those without dependency. An interaction was noted between reduced FI and multimorbidity (p for interaction < 0.001). Compared to non-multimorbid patients (OR = 3.71, 95% CI: [1.58, 9.16]), multimorbid patients (OR = 10.04, 95% CI: [5.63, 18.57]) had a more pronounced risk of severe or critical infection. Conclusions Our results provide further scientific evidence on the association between FI, multimorbidity, and disease severity in older COVID-19 patients, contributing to future health decision-making for COVID-19 and other infectious diseases.https://doi.org/10.1186/s12877-025-05739-6MultimorbidityFunctional independenceBarthel indexOmicronOlder patients |
| spellingShingle | Wan Yu Runnian Huang Shuning Sun Li Bu Xin Chen Yunhua Di Shuwu Lin Qian Li Yang Yang Xingyue Ye Wenxu Wang Rui Ren Linze Xi Ru Zhang Yi Li Xin Li Tianbo Hou Zibo Ning Yang Peng Difei Wang Reduced functional independence and multimorbidity increases the risk of severe infection among older patients with Omicron: a multicenter retrospective cohort study BMC Geriatrics Multimorbidity Functional independence Barthel index Omicron Older patients |
| title | Reduced functional independence and multimorbidity increases the risk of severe infection among older patients with Omicron: a multicenter retrospective cohort study |
| title_full | Reduced functional independence and multimorbidity increases the risk of severe infection among older patients with Omicron: a multicenter retrospective cohort study |
| title_fullStr | Reduced functional independence and multimorbidity increases the risk of severe infection among older patients with Omicron: a multicenter retrospective cohort study |
| title_full_unstemmed | Reduced functional independence and multimorbidity increases the risk of severe infection among older patients with Omicron: a multicenter retrospective cohort study |
| title_short | Reduced functional independence and multimorbidity increases the risk of severe infection among older patients with Omicron: a multicenter retrospective cohort study |
| title_sort | reduced functional independence and multimorbidity increases the risk of severe infection among older patients with omicron a multicenter retrospective cohort study |
| topic | Multimorbidity Functional independence Barthel index Omicron Older patients |
| url | https://doi.org/10.1186/s12877-025-05739-6 |
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