Single-cell multi-omics analysis reveals candidate therapeutic drugs and key transcription factor specifically for the mesenchymal subtype of glioblastoma

Single-cell multi-omics analysis reveals candidate therapeutic drugs and key transcription factor specifically for the mesenchymal subtype of glioblastoma

Abstract The inherent heterogeneity of tumor cells impedes the development of targeted therapies for specific glioblastoma (GBM) subtypes. This study aims to investigate the mesenchymal subtype of GBM to uncover detailed characteristics, potential therapeutic strategies, and improve precision treatm...

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Bibliographic Details
Main Authors: Yufan Yang, Ziyuan Liu, Yerong Wei, Shuai He, Ancheng Gu, Zhiyong Li, Jianlong Li, Zhongyuan Xu, Bohong Cen
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell & Bioscience
Subjects:
Single-cell RNA sequencing
SnATAC-seq
Glioblastoma
Mesenchymal
Therapeutic drugs
Transcription factor
Online Access:https://doi.org/10.1186/s13578-024-01332-3
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