Forceps minor control of social behaviour
Abstract The PRISM project, funded by the EU’s Innovative Medicines Initiative, has identified a transdiagnostic, pathophysiological relationship between the integrity of the default mode network (DMN) and social dysfunction. To explore the causal link between DMN integrity and social behaviour, we...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-81930-w |
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| _version_ | 1850244385076150272 |
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| author | Franziska Stoller Eleanor Hinds Tudor Ionescu Elmira Khatamsaz Hugh M. Marston Bastian Hengerer |
| author_facet | Franziska Stoller Eleanor Hinds Tudor Ionescu Elmira Khatamsaz Hugh M. Marston Bastian Hengerer |
| author_sort | Franziska Stoller |
| collection | DOAJ |
| description | Abstract The PRISM project, funded by the EU’s Innovative Medicines Initiative, has identified a transdiagnostic, pathophysiological relationship between the integrity of the default mode network (DMN) and social dysfunction. To explore the causal link between DMN integrity and social behaviour, we employed a preclinical back-translation approach, using focal demyelination of the forceps minor to disrupt DMN connectivity in mice. By applying advanced techniques such as functional ultrasound imaging and automated analysis of social behaviour, we demonstrated that reduced DMN connectivity leads to impaired social interactions and increased anxiety in mice. Notably, these effects were reversible, indicating that the forceps minor, a critical fibre tract connecting key DMN regions in the prefrontal cortex, plays a crucial role in social function. This study provides direct evidence for a causal relationship between DMN integrity and social dysfunction, with potential implications for developing targeted treatments in precision psychiatry. |
| format | Article |
| id | doaj-art-5e488847fbb44cd3801a0b2779d8e70b |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-5e488847fbb44cd3801a0b2779d8e70b2025-08-20T01:59:44ZengNature PortfolioScientific Reports2045-23222024-12-0114111410.1038/s41598-024-81930-wForceps minor control of social behaviourFranziska Stoller0Eleanor Hinds1Tudor Ionescu2Elmira Khatamsaz3Hugh M. Marston4Bastian Hengerer5Boehringer Ingelheim Pharma GmbH & Co. KGBoehringer Ingelheim Pharma GmbH & Co. KGBoehringer Ingelheim Pharma GmbH & Co. KGBoehringer Ingelheim Pharma GmbH & Co. KGBoehringer Ingelheim Pharma GmbH & Co. KGBoehringer Ingelheim Pharma GmbH & Co. KGAbstract The PRISM project, funded by the EU’s Innovative Medicines Initiative, has identified a transdiagnostic, pathophysiological relationship between the integrity of the default mode network (DMN) and social dysfunction. To explore the causal link between DMN integrity and social behaviour, we employed a preclinical back-translation approach, using focal demyelination of the forceps minor to disrupt DMN connectivity in mice. By applying advanced techniques such as functional ultrasound imaging and automated analysis of social behaviour, we demonstrated that reduced DMN connectivity leads to impaired social interactions and increased anxiety in mice. Notably, these effects were reversible, indicating that the forceps minor, a critical fibre tract connecting key DMN regions in the prefrontal cortex, plays a crucial role in social function. This study provides direct evidence for a causal relationship between DMN integrity and social dysfunction, with potential implications for developing targeted treatments in precision psychiatry.https://doi.org/10.1038/s41598-024-81930-w |
| spellingShingle | Franziska Stoller Eleanor Hinds Tudor Ionescu Elmira Khatamsaz Hugh M. Marston Bastian Hengerer Forceps minor control of social behaviour Scientific Reports |
| title | Forceps minor control of social behaviour |
| title_full | Forceps minor control of social behaviour |
| title_fullStr | Forceps minor control of social behaviour |
| title_full_unstemmed | Forceps minor control of social behaviour |
| title_short | Forceps minor control of social behaviour |
| title_sort | forceps minor control of social behaviour |
| url | https://doi.org/10.1038/s41598-024-81930-w |
| work_keys_str_mv | AT franziskastoller forcepsminorcontrolofsocialbehaviour AT eleanorhinds forcepsminorcontrolofsocialbehaviour AT tudorionescu forcepsminorcontrolofsocialbehaviour AT elmirakhatamsaz forcepsminorcontrolofsocialbehaviour AT hughmmarston forcepsminorcontrolofsocialbehaviour AT bastianhengerer forcepsminorcontrolofsocialbehaviour |