Assessment of cardiovascular risk in patients with crystal-induced arthritides and rheumatoid arthritis by the ATP III and Reynolds Risk Score
Cardiovascular risk (CVR) in patients with calcium pyrophosphate crystal deposition disease (CPPD) has not been studied, and the optimal method for assessing it has not been established yet.Objective: Evaluation of CVR and comparison of results using Adult Treatment Panel III (ATP III) and Reynolds...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA PRESS LLC
2020-11-01
|
| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2954 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849400832228851712 |
|---|---|
| author | M. S. Eliseev A. M. Novikova O. V. Zhelyabina E. V. Gerasimova E. V. Ilyinykh T. V. Popkova T. S. Panevin E. L. Nasonov |
| author_facet | M. S. Eliseev A. M. Novikova O. V. Zhelyabina E. V. Gerasimova E. V. Ilyinykh T. V. Popkova T. S. Panevin E. L. Nasonov |
| author_sort | M. S. Eliseev |
| collection | DOAJ |
| description | Cardiovascular risk (CVR) in patients with calcium pyrophosphate crystal deposition disease (CPPD) has not been studied, and the optimal method for assessing it has not been established yet.Objective: Evaluation of CVR and comparison of results using Adult Treatment Panel III (ATP III) and Reynolds Risk Score (RRS) scales in patients with CPPD, gout, rheumatoid arthritis (RA) and in the control group.Materials and methods: Cross-sectional, single-center study performed by case-control method. There are 42 patients with CPPD in main group, 42 patients with gout and RA in the comparison groups are, 42 healthy volunteers in the control group. The survey included measurements of anthropometric measures, blood pressure (BP), serum glucose, creatinine, cholesterol (TC), high density lipoproteins (HDL), low density lipoproteins (LDL), C-reactive protein (CRP). CVR was assessed on ATP III and RRS scales, comparison of its evaluation results was carried out between groups and between scales within groups.Results and discussion: Most of the parameters in the compared groups did not differ. However, HDL CS levels were significantly higher in patients with CPPD and in the control group than in RA and gout (p<0.05). In addition, in patients with gout and RA, systolic BP was higher than in CPPD and in control (p<0.05).CRP in CPPD was lower than in gout and RA and was not significantly different from this indicator in the control group. Its median was 3.8 [1.0; 12.4], 8.5 [4.1; 12.9] (р <0.05), 8.6 [4.1; 20.6] (р<0.05), 1.5 [0.8; 2.6] mg/l (p>0.05). The CRP > 5 mg/L in CPPD and in the control group was greater than in RA (p<0.05) and gout (p<0.05), but CRP≥5 mg/L was determined in 18 patients (43%) with CPPD and only in 3 (7%) people in the control group (p<0.05). A high and very high risk of cardiovascular disease (CVD) on the ATP III scale in CPPD was noted in 5 (12%) in gout – in 7 (17%), in RA – in 9 (21%) and in the control group – in 8 (19%) cases. Its frequency in all groups was comparable.A high and very high risk of CVD for RRS was identified in 9 (21%), 14 (33%), 12 (29%) and 7 (17%) cases, respectively.Conclusions: CVR under CPPD, RA and gout is comparable and quite high. The RRS scale may be a more objective method of assessing CVD risk in patients with CPPD, gout and RA. |
| format | Article |
| id | doaj-art-5e44ff3edf2441d4a2808b6ad464db32 |
| institution | Kabale University |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2020-11-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-5e44ff3edf2441d4a2808b6ad464db322025-08-20T03:37:54ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922020-11-0158551251910.47360/1995-4484-2020-512-5192652Assessment of cardiovascular risk in patients with crystal-induced arthritides and rheumatoid arthritis by the ATP III and Reynolds Risk ScoreM. S. Eliseev0A. M. Novikova1O. V. Zhelyabina2E. V. Gerasimova3E. V. Ilyinykh4T. V. Popkova5T. S. Panevin6E. L. Nasonov7VA Nasonova Research Institute of RheumatologyVA Nasonova Research Institute of RheumatologyVA Nasonova Research Institute of RheumatologyVA Nasonova Research Institute of RheumatologyVA Nasonova Research Institute of RheumatologyVA Nasonova Research Institute of RheumatologyVA Nasonova Research Institute of RheumatologyVA Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaCardiovascular risk (CVR) in patients with calcium pyrophosphate crystal deposition disease (CPPD) has not been studied, and the optimal method for assessing it has not been established yet.Objective: Evaluation of CVR and comparison of results using Adult Treatment Panel III (ATP III) and Reynolds Risk Score (RRS) scales in patients with CPPD, gout, rheumatoid arthritis (RA) and in the control group.Materials and methods: Cross-sectional, single-center study performed by case-control method. There are 42 patients with CPPD in main group, 42 patients with gout and RA in the comparison groups are, 42 healthy volunteers in the control group. The survey included measurements of anthropometric measures, blood pressure (BP), serum glucose, creatinine, cholesterol (TC), high density lipoproteins (HDL), low density lipoproteins (LDL), C-reactive protein (CRP). CVR was assessed on ATP III and RRS scales, comparison of its evaluation results was carried out between groups and between scales within groups.Results and discussion: Most of the parameters in the compared groups did not differ. However, HDL CS levels were significantly higher in patients with CPPD and in the control group than in RA and gout (p<0.05). In addition, in patients with gout and RA, systolic BP was higher than in CPPD and in control (p<0.05).CRP in CPPD was lower than in gout and RA and was not significantly different from this indicator in the control group. Its median was 3.8 [1.0; 12.4], 8.5 [4.1; 12.9] (р <0.05), 8.6 [4.1; 20.6] (р<0.05), 1.5 [0.8; 2.6] mg/l (p>0.05). The CRP > 5 mg/L in CPPD and in the control group was greater than in RA (p<0.05) and gout (p<0.05), but CRP≥5 mg/L was determined in 18 patients (43%) with CPPD and only in 3 (7%) people in the control group (p<0.05). A high and very high risk of cardiovascular disease (CVD) on the ATP III scale in CPPD was noted in 5 (12%) in gout – in 7 (17%), in RA – in 9 (21%) and in the control group – in 8 (19%) cases. Its frequency in all groups was comparable.A high and very high risk of CVD for RRS was identified in 9 (21%), 14 (33%), 12 (29%) and 7 (17%) cases, respectively.Conclusions: CVR under CPPD, RA and gout is comparable and quite high. The RRS scale may be a more objective method of assessing CVD risk in patients with CPPD, gout and RA.https://rsp.mediar-press.net/rsp/article/view/2954calcium pyrophosphate crystals deposit diseasegoutrheumatoid arthritiscardiovascular riskinflammationc-reactive proteinreynolds risk scoreadult treatment panel iii |
| spellingShingle | M. S. Eliseev A. M. Novikova O. V. Zhelyabina E. V. Gerasimova E. V. Ilyinykh T. V. Popkova T. S. Panevin E. L. Nasonov Assessment of cardiovascular risk in patients with crystal-induced arthritides and rheumatoid arthritis by the ATP III and Reynolds Risk Score Научно-практическая ревматология calcium pyrophosphate crystals deposit disease gout rheumatoid arthritis cardiovascular risk inflammation c-reactive protein reynolds risk score adult treatment panel iii |
| title | Assessment of cardiovascular risk in patients with crystal-induced arthritides and rheumatoid arthritis by the ATP III and Reynolds Risk Score |
| title_full | Assessment of cardiovascular risk in patients with crystal-induced arthritides and rheumatoid arthritis by the ATP III and Reynolds Risk Score |
| title_fullStr | Assessment of cardiovascular risk in patients with crystal-induced arthritides and rheumatoid arthritis by the ATP III and Reynolds Risk Score |
| title_full_unstemmed | Assessment of cardiovascular risk in patients with crystal-induced arthritides and rheumatoid arthritis by the ATP III and Reynolds Risk Score |
| title_short | Assessment of cardiovascular risk in patients with crystal-induced arthritides and rheumatoid arthritis by the ATP III and Reynolds Risk Score |
| title_sort | assessment of cardiovascular risk in patients with crystal induced arthritides and rheumatoid arthritis by the atp iii and reynolds risk score |
| topic | calcium pyrophosphate crystals deposit disease gout rheumatoid arthritis cardiovascular risk inflammation c-reactive protein reynolds risk score adult treatment panel iii |
| url | https://rsp.mediar-press.net/rsp/article/view/2954 |
| work_keys_str_mv | AT mseliseev assessmentofcardiovascularriskinpatientswithcrystalinducedarthritidesandrheumatoidarthritisbytheatpiiiandreynoldsriskscore AT amnovikova assessmentofcardiovascularriskinpatientswithcrystalinducedarthritidesandrheumatoidarthritisbytheatpiiiandreynoldsriskscore AT ovzhelyabina assessmentofcardiovascularriskinpatientswithcrystalinducedarthritidesandrheumatoidarthritisbytheatpiiiandreynoldsriskscore AT evgerasimova assessmentofcardiovascularriskinpatientswithcrystalinducedarthritidesandrheumatoidarthritisbytheatpiiiandreynoldsriskscore AT evilyinykh assessmentofcardiovascularriskinpatientswithcrystalinducedarthritidesandrheumatoidarthritisbytheatpiiiandreynoldsriskscore AT tvpopkova assessmentofcardiovascularriskinpatientswithcrystalinducedarthritidesandrheumatoidarthritisbytheatpiiiandreynoldsriskscore AT tspanevin assessmentofcardiovascularriskinpatientswithcrystalinducedarthritidesandrheumatoidarthritisbytheatpiiiandreynoldsriskscore AT elnasonov assessmentofcardiovascularriskinpatientswithcrystalinducedarthritidesandrheumatoidarthritisbytheatpiiiandreynoldsriskscore |