Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics
Abstract Neutrophil extracellular traps (NETs) participate in both host defense and the pathogenesis of various diseases, such as infections, thrombosis, and tumors. While they help capture and eliminate pathogens, NETs’ excessive or dysregulated formation can lead to tissue damage and disease progr...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03195-3 |
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| author | Haisong Li Can Li Cong Fu Yizhuo Wang Tingting Liang Haitao Wu Chenxi Wu Chang Wang Tianmeng Sun Shuhan Liu |
| author_facet | Haisong Li Can Li Cong Fu Yizhuo Wang Tingting Liang Haitao Wu Chenxi Wu Chang Wang Tianmeng Sun Shuhan Liu |
| author_sort | Haisong Li |
| collection | DOAJ |
| description | Abstract Neutrophil extracellular traps (NETs) participate in both host defense and the pathogenesis of various diseases, such as infections, thrombosis, and tumors. While they help capture and eliminate pathogens, NETs’ excessive or dysregulated formation can lead to tissue damage and disease progression. Therapeutic strategies targeting NET modulation have shown potential, but challenges remain, particularly in achieving precise drug delivery and maintaining drug stability. Nanoparticle (NP)-based drug delivery systems offer innovative solutions for overcoming the limitations of conventional therapies. This review explores the biological mechanisms of NET formation, their interactions with NPs, and the therapeutic applications of NP-based drug delivery systems for modulating NETs. We discuss how NPs can be designed to either promote or inhibit NET formation and provide a comprehensive analysis of their potential in treating NET-related diseases. Additionally, we address the current challenges and future prospects for NP-based therapies in NET research, aiming to bridge the gap between nanotechnology and NET modulation for the development of novel therapeutic approaches. Graphical Abstract |
| format | Article |
| id | doaj-art-5e42e20fa88b4ad689547dbc3bb1560d |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-5e42e20fa88b4ad689547dbc3bb1560d2025-02-09T12:53:06ZengBMCJournal of Nanobiotechnology1477-31552025-02-0123113010.1186/s12951-025-03195-3Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeuticsHaisong Li0Can Li1Cong Fu2Yizhuo Wang3Tingting Liang4Haitao Wu5Chenxi Wu6Chang Wang7Tianmeng Sun8Shuhan Liu9Cancer Center, The First Hospital, Jilin UniversityDepartment of Hematology, The Second Clinical Medical College of Shanxi Medical UniversityKey Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin UniversityCancer Center, The First Hospital, Jilin UniversityCancer Center, The First Hospital, Jilin UniversityCancer Center, The First Hospital, Jilin UniversityCancer Center, The First Hospital, Jilin UniversityCancer Center, The First Hospital, Jilin UniversityKey Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin UniversityCancer Center, The First Hospital, Jilin UniversityAbstract Neutrophil extracellular traps (NETs) participate in both host defense and the pathogenesis of various diseases, such as infections, thrombosis, and tumors. While they help capture and eliminate pathogens, NETs’ excessive or dysregulated formation can lead to tissue damage and disease progression. Therapeutic strategies targeting NET modulation have shown potential, but challenges remain, particularly in achieving precise drug delivery and maintaining drug stability. Nanoparticle (NP)-based drug delivery systems offer innovative solutions for overcoming the limitations of conventional therapies. This review explores the biological mechanisms of NET formation, their interactions with NPs, and the therapeutic applications of NP-based drug delivery systems for modulating NETs. We discuss how NPs can be designed to either promote or inhibit NET formation and provide a comprehensive analysis of their potential in treating NET-related diseases. Additionally, we address the current challenges and future prospects for NP-based therapies in NET research, aiming to bridge the gap between nanotechnology and NET modulation for the development of novel therapeutic approaches. Graphical Abstracthttps://doi.org/10.1186/s12951-025-03195-3Neutrophil extracellular traps (NETs)Nanoparticle (NP)Drug deliveryNeutrophilsNET modulation |
| spellingShingle | Haisong Li Can Li Cong Fu Yizhuo Wang Tingting Liang Haitao Wu Chenxi Wu Chang Wang Tianmeng Sun Shuhan Liu Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics Journal of Nanobiotechnology Neutrophil extracellular traps (NETs) Nanoparticle (NP) Drug delivery Neutrophils NET modulation |
| title | Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics |
| title_full | Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics |
| title_fullStr | Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics |
| title_full_unstemmed | Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics |
| title_short | Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics |
| title_sort | innovative nanoparticle based approaches for modulating neutrophil extracellular traps in diseases from mechanisms to therapeutics |
| topic | Neutrophil extracellular traps (NETs) Nanoparticle (NP) Drug delivery Neutrophils NET modulation |
| url | https://doi.org/10.1186/s12951-025-03195-3 |
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