Complexation Strategies for Enhancing Water-Soluble Protein Stability and Functionality: A Comprehensive Review
Water-soluble proteins, as ideal ingredients in food systems, have attracted much attention. However, their applications in the food industry are still limited by inherent shortcomings in stability and functionalities. Complexation with ligands is an effective strategy to overcome these limitations....
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| Format: | Article |
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MDPI AG
2025-07-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/14/13/2359 |
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| author | Qing Guo Xu Qi Yuying Hu |
| author_facet | Qing Guo Xu Qi Yuying Hu |
| author_sort | Qing Guo |
| collection | DOAJ |
| description | Water-soluble proteins, as ideal ingredients in food systems, have attracted much attention. However, their applications in the food industry are still limited by inherent shortcomings in stability and functionalities. Complexation with ligands is an effective strategy to overcome these limitations. In the present review, we summarize (1) the interaction mechanisms between water-soluble proteins and ligands; (2) the enhancement of the stability and functionalities of water-soluble proteins; (3) the influences of the nature of proteins and ligands, along with complexing conditions, on their interactions and enhancement of the stability and functionalities of water-soluble proteins; and (4) the applications of water-soluble protein-based complexes. Promising future research trends in the field of water-soluble protein-based complexes are also discussed. This review aims to offer theoretical guidance and technical support for the precise enhancement of protein stability and functionalities, thereby promoting their broader application in the food industry. |
| format | Article |
| id | doaj-art-5e3d836a8bbb46a49a1c79b5a359bf68 |
| institution | OA Journals |
| issn | 2304-8158 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj-art-5e3d836a8bbb46a49a1c79b5a359bf682025-08-20T02:35:43ZengMDPI AGFoods2304-81582025-07-011413235910.3390/foods14132359Complexation Strategies for Enhancing Water-Soluble Protein Stability and Functionality: A Comprehensive ReviewQing Guo0Xu Qi1Yuying Hu2State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, ChinaState Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, ChinaSchool of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, ChinaWater-soluble proteins, as ideal ingredients in food systems, have attracted much attention. However, their applications in the food industry are still limited by inherent shortcomings in stability and functionalities. Complexation with ligands is an effective strategy to overcome these limitations. In the present review, we summarize (1) the interaction mechanisms between water-soluble proteins and ligands; (2) the enhancement of the stability and functionalities of water-soluble proteins; (3) the influences of the nature of proteins and ligands, along with complexing conditions, on their interactions and enhancement of the stability and functionalities of water-soluble proteins; and (4) the applications of water-soluble protein-based complexes. Promising future research trends in the field of water-soluble protein-based complexes are also discussed. This review aims to offer theoretical guidance and technical support for the precise enhancement of protein stability and functionalities, thereby promoting their broader application in the food industry.https://www.mdpi.com/2304-8158/14/13/2359water-soluble proteincomplexationstabilityfunctionality |
| spellingShingle | Qing Guo Xu Qi Yuying Hu Complexation Strategies for Enhancing Water-Soluble Protein Stability and Functionality: A Comprehensive Review Foods water-soluble protein complexation stability functionality |
| title | Complexation Strategies for Enhancing Water-Soluble Protein Stability and Functionality: A Comprehensive Review |
| title_full | Complexation Strategies for Enhancing Water-Soluble Protein Stability and Functionality: A Comprehensive Review |
| title_fullStr | Complexation Strategies for Enhancing Water-Soluble Protein Stability and Functionality: A Comprehensive Review |
| title_full_unstemmed | Complexation Strategies for Enhancing Water-Soluble Protein Stability and Functionality: A Comprehensive Review |
| title_short | Complexation Strategies for Enhancing Water-Soluble Protein Stability and Functionality: A Comprehensive Review |
| title_sort | complexation strategies for enhancing water soluble protein stability and functionality a comprehensive review |
| topic | water-soluble protein complexation stability functionality |
| url | https://www.mdpi.com/2304-8158/14/13/2359 |
| work_keys_str_mv | AT qingguo complexationstrategiesforenhancingwatersolubleproteinstabilityandfunctionalityacomprehensivereview AT xuqi complexationstrategiesforenhancingwatersolubleproteinstabilityandfunctionalityacomprehensivereview AT yuyinghu complexationstrategiesforenhancingwatersolubleproteinstabilityandfunctionalityacomprehensivereview |