Analyzing the non-linear relationship between fasting blood glucose levels and Gensini score in patients with STEMI
BackgroundAcute myocardial infarction (AMI), particularly ST-segment elevation myocardial infarction (STEMI), significantly impacts global health, exacerbated by risk factors such as diabetes mellitus (DM). While the Gensini score effectively quantifies coronary artery lesions, its correlation with...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1427567/full |
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| author | Han Li Quanzhi Lin Zhiyuan Jiang Guoqiang Zhong |
| author_facet | Han Li Quanzhi Lin Zhiyuan Jiang Guoqiang Zhong |
| author_sort | Han Li |
| collection | DOAJ |
| description | BackgroundAcute myocardial infarction (AMI), particularly ST-segment elevation myocardial infarction (STEMI), significantly impacts global health, exacerbated by risk factors such as diabetes mellitus (DM). While the Gensini score effectively quantifies coronary artery lesions, its correlation with fasting blood glucose (FBG) levels, particularly in a non-linear fashion, has not been thoroughly explored in STEMI patients.MethodsThis study analyzed data from 464 STEMI patients treated with percutaneous coronary intervention at the First People's Hospital of Taizhou City, Zhejiang Province, China, from January 2010 to October 2014. We stratified patients into three FBG tertiles and utilized multiple statistical analyses, including least absolute shrinkage and selection operator (LASSO) regression and curve fitting, to examine the potential U-shaped relationship between FBG levels and Gensini scores.ResultsOur analysis revealed significant differences in Gensini scores across FBG tertiles, with both hypoglycemic and hyperglycemic extremes showing higher scores compared to the normoglycemic range. The curve fitting analysis confirmed a U-shaped relationship, suggesting a significant, non-linear association between FBG levels and coronary artery lesion severity, regardless of diabetes status.ConclusionsOur findings underscore the complexity of glycemic control in STEMI management and suggest that both hypo- and hyperglycemia are significant risk factors for severe coronary lesions as quantified by the Gensini score. This study highlights the importance of comprehensive FBG monitoring and management to improve outcomes for STEMI patients. |
| format | Article |
| id | doaj-art-5e35801a7a564d1e8e7e840f398f04ba |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-5e35801a7a564d1e8e7e840f398f04ba2025-08-20T01:58:08ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-12-011110.3389/fcvm.2024.14275671427567Analyzing the non-linear relationship between fasting blood glucose levels and Gensini score in patients with STEMIHan Li0Quanzhi Lin1Zhiyuan Jiang2Guoqiang Zhong3Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Cardiology, The First Affiliated Hospital of Guangxi University of Science and Technology, Liuzhou, Guangxi, ChinaDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaBackgroundAcute myocardial infarction (AMI), particularly ST-segment elevation myocardial infarction (STEMI), significantly impacts global health, exacerbated by risk factors such as diabetes mellitus (DM). While the Gensini score effectively quantifies coronary artery lesions, its correlation with fasting blood glucose (FBG) levels, particularly in a non-linear fashion, has not been thoroughly explored in STEMI patients.MethodsThis study analyzed data from 464 STEMI patients treated with percutaneous coronary intervention at the First People's Hospital of Taizhou City, Zhejiang Province, China, from January 2010 to October 2014. We stratified patients into three FBG tertiles and utilized multiple statistical analyses, including least absolute shrinkage and selection operator (LASSO) regression and curve fitting, to examine the potential U-shaped relationship between FBG levels and Gensini scores.ResultsOur analysis revealed significant differences in Gensini scores across FBG tertiles, with both hypoglycemic and hyperglycemic extremes showing higher scores compared to the normoglycemic range. The curve fitting analysis confirmed a U-shaped relationship, suggesting a significant, non-linear association between FBG levels and coronary artery lesion severity, regardless of diabetes status.ConclusionsOur findings underscore the complexity of glycemic control in STEMI management and suggest that both hypo- and hyperglycemia are significant risk factors for severe coronary lesions as quantified by the Gensini score. This study highlights the importance of comprehensive FBG monitoring and management to improve outcomes for STEMI patients.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1427567/fullacute myocardial infarctionGensini scorefasting blood glucoseST-elevation myocardial infarctiondiabetes mellitus |
| spellingShingle | Han Li Quanzhi Lin Zhiyuan Jiang Guoqiang Zhong Analyzing the non-linear relationship between fasting blood glucose levels and Gensini score in patients with STEMI Frontiers in Cardiovascular Medicine acute myocardial infarction Gensini score fasting blood glucose ST-elevation myocardial infarction diabetes mellitus |
| title | Analyzing the non-linear relationship between fasting blood glucose levels and Gensini score in patients with STEMI |
| title_full | Analyzing the non-linear relationship between fasting blood glucose levels and Gensini score in patients with STEMI |
| title_fullStr | Analyzing the non-linear relationship between fasting blood glucose levels and Gensini score in patients with STEMI |
| title_full_unstemmed | Analyzing the non-linear relationship between fasting blood glucose levels and Gensini score in patients with STEMI |
| title_short | Analyzing the non-linear relationship between fasting blood glucose levels and Gensini score in patients with STEMI |
| title_sort | analyzing the non linear relationship between fasting blood glucose levels and gensini score in patients with stemi |
| topic | acute myocardial infarction Gensini score fasting blood glucose ST-elevation myocardial infarction diabetes mellitus |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1427567/full |
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