Interest of Colchicine for the Treatment of Cystic Fibrosis Patients. Preliminary Report
Cystic fibrosis (CF) lung disease is characterized by persistent inflammation. Antiinflammatory drugs, such as corticosteroids and ibuprofene, have proved to slow the decline of pulmonary function although their use is limited because of frequent adverse events. We hypothesized that colchicine could...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1999-01-01
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| Series: | Mediators of Inflammation |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09629359990667 |
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| author | I. Sermet-Gaudelus V. Stoven J. P. Annereau V. Witko-Sarsat P. Reinert M. Guyot B. Descamps-Latscha J. Y. Lallemand G. Lenoir |
| author_facet | I. Sermet-Gaudelus V. Stoven J. P. Annereau V. Witko-Sarsat P. Reinert M. Guyot B. Descamps-Latscha J. Y. Lallemand G. Lenoir |
| author_sort | I. Sermet-Gaudelus |
| collection | DOAJ |
| description | Cystic fibrosis (CF) lung disease is characterized by persistent inflammation. Antiinflammatory drugs, such as corticosteroids and ibuprofene, have proved to slow the decline of pulmonary function although their use is limited because of frequent adverse events. We hypothesized that colchicine could be an alternative treatment because of its antiinflammatory properties and upregulatory effect on cystic fibrosis transmembrane regulator (CFTR) closely related proteins. We herein present results obtained in an open study of eight CF children treated with colchicine for at least 6 months. Clinical status was better in all patients and respiratory function tests significantly improved in five. Median duration of antibiotherapy decreased significantly. These preliminary results support our hypothesis of a beneficial effect of colchicine in CF patients and stress the need for a controlled therapeutic trial. |
| format | Article |
| id | doaj-art-5e34d8f38bba49ddba6abe7bf2e4c693 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5e34d8f38bba49ddba6abe7bf2e4c6932025-08-20T02:06:03ZengWileyMediators of Inflammation0962-93511466-18611999-01-0181131510.1080/09629359990667Interest of Colchicine for the Treatment of Cystic Fibrosis Patients. Preliminary ReportI. Sermet-Gaudelus0V. Stoven1J. P. Annereau2V. Witko-Sarsat3P. Reinert4M. Guyot5B. Descamps-Latscha6J. Y. Lallemand7G. Lenoir8Service de Pédiatrie II, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, Paris 75015, FranceLaboratoire de Résonnance Magnétique Nucléaire, Ecole Polytechnique, Massy Palaiseau, FranceLaboratoire de Résonnance Magnétique Nucléaire, Ecole Polytechnique, Massy Palaiseau, FranceINSERM U507, Hôpital Necker, Paris, FrancePediatric Department, Hôpital Intercommunal, Créteil, FrancePediatric Department, Hôpital de Lisieux, FranceINSERM U507, Hôpital Necker, Paris, FranceLaboratoire de Résonnance Magnétique Nucléaire, Ecole Polytechnique, Massy Palaiseau, FranceService de Pédiatrie II, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, Paris 75015, FranceCystic fibrosis (CF) lung disease is characterized by persistent inflammation. Antiinflammatory drugs, such as corticosteroids and ibuprofene, have proved to slow the decline of pulmonary function although their use is limited because of frequent adverse events. We hypothesized that colchicine could be an alternative treatment because of its antiinflammatory properties and upregulatory effect on cystic fibrosis transmembrane regulator (CFTR) closely related proteins. We herein present results obtained in an open study of eight CF children treated with colchicine for at least 6 months. Clinical status was better in all patients and respiratory function tests significantly improved in five. Median duration of antibiotherapy decreased significantly. These preliminary results support our hypothesis of a beneficial effect of colchicine in CF patients and stress the need for a controlled therapeutic trial.http://dx.doi.org/10.1080/09629359990667Cystic FibrosisInflammationCystic fibrosis transmembrane regulatorABC proteinColchicine. |
| spellingShingle | I. Sermet-Gaudelus V. Stoven J. P. Annereau V. Witko-Sarsat P. Reinert M. Guyot B. Descamps-Latscha J. Y. Lallemand G. Lenoir Interest of Colchicine for the Treatment of Cystic Fibrosis Patients. Preliminary Report Mediators of Inflammation Cystic Fibrosis Inflammation Cystic fibrosis transmembrane regulator ABC protein Colchicine. |
| title | Interest of Colchicine for the Treatment of Cystic Fibrosis Patients. Preliminary Report |
| title_full | Interest of Colchicine for the Treatment of Cystic Fibrosis Patients. Preliminary Report |
| title_fullStr | Interest of Colchicine for the Treatment of Cystic Fibrosis Patients. Preliminary Report |
| title_full_unstemmed | Interest of Colchicine for the Treatment of Cystic Fibrosis Patients. Preliminary Report |
| title_short | Interest of Colchicine for the Treatment of Cystic Fibrosis Patients. Preliminary Report |
| title_sort | interest of colchicine for the treatment of cystic fibrosis patients preliminary report |
| topic | Cystic Fibrosis Inflammation Cystic fibrosis transmembrane regulator ABC protein Colchicine. |
| url | http://dx.doi.org/10.1080/09629359990667 |
| work_keys_str_mv | AT isermetgaudelus interestofcolchicineforthetreatmentofcysticfibrosispatientspreliminaryreport AT vstoven interestofcolchicineforthetreatmentofcysticfibrosispatientspreliminaryreport AT jpannereau interestofcolchicineforthetreatmentofcysticfibrosispatientspreliminaryreport AT vwitkosarsat interestofcolchicineforthetreatmentofcysticfibrosispatientspreliminaryreport AT preinert interestofcolchicineforthetreatmentofcysticfibrosispatientspreliminaryreport AT mguyot interestofcolchicineforthetreatmentofcysticfibrosispatientspreliminaryreport AT bdescampslatscha interestofcolchicineforthetreatmentofcysticfibrosispatientspreliminaryreport AT jylallemand interestofcolchicineforthetreatmentofcysticfibrosispatientspreliminaryreport AT glenoir interestofcolchicineforthetreatmentofcysticfibrosispatientspreliminaryreport |