Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia

The lower urinary tract symptoms (LUTSs) and acute urinary retention (AUR) caused by benign prostatic hyperplasia (BPH) can seriously affect the quality of life of elderly men. Studies suggest that both androgens and inflammation greatly influence the occurrence and development of BPH in most patien...

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Main Authors: Yu Tong, Ren-yuan Zhou
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2020/7958316
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author Yu Tong
Ren-yuan Zhou
author_facet Yu Tong
Ren-yuan Zhou
author_sort Yu Tong
collection DOAJ
description The lower urinary tract symptoms (LUTSs) and acute urinary retention (AUR) caused by benign prostatic hyperplasia (BPH) can seriously affect the quality of life of elderly men. Studies suggest that both androgens and inflammation greatly influence the occurrence and development of BPH in most patients. These two factors combined can also affect each other, leading to pathological changes in the stromal and epithelial tissue of the prostate transition zone in BPH patients. DHT in the prostate tissue of BPH patients may activate a chronic inflammatory response in the prostate, amplifying the expression of inflammatory factors and upregulating the proliferation ability of prostate tissue.
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spelling doaj-art-5e3467ed6b9c4826a77a939831fbfedf2025-02-03T05:51:15ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/79583167958316Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic HyperplasiaYu Tong0Ren-yuan Zhou1Department of Urology, Jing’an District Central Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Urology, Jing’an District Central Hospital, Fudan University, Shanghai 200040, ChinaThe lower urinary tract symptoms (LUTSs) and acute urinary retention (AUR) caused by benign prostatic hyperplasia (BPH) can seriously affect the quality of life of elderly men. Studies suggest that both androgens and inflammation greatly influence the occurrence and development of BPH in most patients. These two factors combined can also affect each other, leading to pathological changes in the stromal and epithelial tissue of the prostate transition zone in BPH patients. DHT in the prostate tissue of BPH patients may activate a chronic inflammatory response in the prostate, amplifying the expression of inflammatory factors and upregulating the proliferation ability of prostate tissue.http://dx.doi.org/10.1155/2020/7958316
spellingShingle Yu Tong
Ren-yuan Zhou
Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia
Mediators of Inflammation
title Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia
title_full Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia
title_fullStr Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia
title_full_unstemmed Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia
title_short Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia
title_sort review of the roles and interaction of androgen and inflammation in benign prostatic hyperplasia
url http://dx.doi.org/10.1155/2020/7958316
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