Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia
The lower urinary tract symptoms (LUTSs) and acute urinary retention (AUR) caused by benign prostatic hyperplasia (BPH) can seriously affect the quality of life of elderly men. Studies suggest that both androgens and inflammation greatly influence the occurrence and development of BPH in most patien...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/7958316 |
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| _version_ | 1832554567693238272 |
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| author | Yu Tong Ren-yuan Zhou |
| author_facet | Yu Tong Ren-yuan Zhou |
| author_sort | Yu Tong |
| collection | DOAJ |
| description | The lower urinary tract symptoms (LUTSs) and acute urinary retention (AUR) caused by benign prostatic hyperplasia (BPH) can seriously affect the quality of life of elderly men. Studies suggest that both androgens and inflammation greatly influence the occurrence and development of BPH in most patients. These two factors combined can also affect each other, leading to pathological changes in the stromal and epithelial tissue of the prostate transition zone in BPH patients. DHT in the prostate tissue of BPH patients may activate a chronic inflammatory response in the prostate, amplifying the expression of inflammatory factors and upregulating the proliferation ability of prostate tissue. |
| format | Article |
| id | doaj-art-5e3467ed6b9c4826a77a939831fbfedf |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5e3467ed6b9c4826a77a939831fbfedf2025-02-03T05:51:15ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/79583167958316Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic HyperplasiaYu Tong0Ren-yuan Zhou1Department of Urology, Jing’an District Central Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Urology, Jing’an District Central Hospital, Fudan University, Shanghai 200040, ChinaThe lower urinary tract symptoms (LUTSs) and acute urinary retention (AUR) caused by benign prostatic hyperplasia (BPH) can seriously affect the quality of life of elderly men. Studies suggest that both androgens and inflammation greatly influence the occurrence and development of BPH in most patients. These two factors combined can also affect each other, leading to pathological changes in the stromal and epithelial tissue of the prostate transition zone in BPH patients. DHT in the prostate tissue of BPH patients may activate a chronic inflammatory response in the prostate, amplifying the expression of inflammatory factors and upregulating the proliferation ability of prostate tissue.http://dx.doi.org/10.1155/2020/7958316 |
| spellingShingle | Yu Tong Ren-yuan Zhou Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia Mediators of Inflammation |
| title | Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia |
| title_full | Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia |
| title_fullStr | Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia |
| title_full_unstemmed | Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia |
| title_short | Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia |
| title_sort | review of the roles and interaction of androgen and inflammation in benign prostatic hyperplasia |
| url | http://dx.doi.org/10.1155/2020/7958316 |
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