Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventions
Hearing loss profoundly affects social engagement, mental health, cognition, and brain development, with sensorineural hearing loss (SNHL) being a major concern. Linked to ototoxic medications, ageing, and noise exposure, SNHL presents significant treatment challenges, highlighting the need for effe...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Enzyme Inhibition and Medicinal Chemistry |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/14756366.2025.2468853 |
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| author | Xingyi Lv Chenyi Yang Xianying Li Yun Liu Yu Yang Tongyan Jin Zhijian Chen Jinjing Jia Min Wang Li Li |
| author_facet | Xingyi Lv Chenyi Yang Xianying Li Yun Liu Yu Yang Tongyan Jin Zhijian Chen Jinjing Jia Min Wang Li Li |
| author_sort | Xingyi Lv |
| collection | DOAJ |
| description | Hearing loss profoundly affects social engagement, mental health, cognition, and brain development, with sensorineural hearing loss (SNHL) being a major concern. Linked to ototoxic medications, ageing, and noise exposure, SNHL presents significant treatment challenges, highlighting the need for effective prevention and regeneration strategies. Ferroptosis, a distinct form of cell death featuring iron-dependent lipid peroxidation, has garnered interest due to its potential role in cancer, ageing, and neuronal degeneration, especially hearing loss. The emerging role of ferroptosis as a crucial mediator in SNHL suggests that it may offer a novel therapeutic target for otoprotection. This review aims to summarise the intricate connection between ferroptosis and SNHL, offering a fresh perspective for exploring targeted therapeutic strategies that could potentially mitigate cochlear cells damage and enhance the quality of life for individuals with hearing impairments. |
| format | Article |
| id | doaj-art-5e3223545b01480e9b8098c7e8bbf446 |
| institution | DOAJ |
| issn | 1475-6366 1475-6374 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Enzyme Inhibition and Medicinal Chemistry |
| spelling | doaj-art-5e3223545b01480e9b8098c7e8bbf4462025-08-20T03:12:09ZengTaylor & Francis GroupJournal of Enzyme Inhibition and Medicinal Chemistry1475-63661475-63742025-12-0140110.1080/14756366.2025.2468853Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventionsXingyi Lv0Chenyi Yang1Xianying Li2Yun Liu3Yu Yang4Tongyan Jin5Zhijian Chen6Jinjing Jia7Min Wang8Li Li9Department of Physiology, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, ChinaDepartment of Physiology, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, ChinaDepartment of Physiology, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, ChinaDepartment of Physiology, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, ChinaDepartment of Physiology, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, ChinaDepartment of Physiology, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, ChinaDepartment of Physiology, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, ChinaDepartment of Physiology, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, ChinaDepartment of Physiology, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, ChinaDepartment of Physiology, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, ChinaHearing loss profoundly affects social engagement, mental health, cognition, and brain development, with sensorineural hearing loss (SNHL) being a major concern. Linked to ototoxic medications, ageing, and noise exposure, SNHL presents significant treatment challenges, highlighting the need for effective prevention and regeneration strategies. Ferroptosis, a distinct form of cell death featuring iron-dependent lipid peroxidation, has garnered interest due to its potential role in cancer, ageing, and neuronal degeneration, especially hearing loss. The emerging role of ferroptosis as a crucial mediator in SNHL suggests that it may offer a novel therapeutic target for otoprotection. This review aims to summarise the intricate connection between ferroptosis and SNHL, offering a fresh perspective for exploring targeted therapeutic strategies that could potentially mitigate cochlear cells damage and enhance the quality of life for individuals with hearing impairments.https://www.tandfonline.com/doi/10.1080/14756366.2025.2468853Hearing lossferroptosisotoprotection |
| spellingShingle | Xingyi Lv Chenyi Yang Xianying Li Yun Liu Yu Yang Tongyan Jin Zhijian Chen Jinjing Jia Min Wang Li Li Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventions Journal of Enzyme Inhibition and Medicinal Chemistry Hearing loss ferroptosis otoprotection |
| title | Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventions |
| title_full | Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventions |
| title_fullStr | Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventions |
| title_full_unstemmed | Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventions |
| title_short | Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventions |
| title_sort | ferroptosis and hearing loss from molecular mechanisms to therapeutic interventions |
| topic | Hearing loss ferroptosis otoprotection |
| url | https://www.tandfonline.com/doi/10.1080/14756366.2025.2468853 |
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