Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques
Prolonged infection and possible evolution of SARS-CoV-2 in patients living with uncontrolled HIV-1 infection highlight the importance of an effective vaccination regimen, yet the immunogenicity of COVID-19 vaccines and predictive immune biomarkers have not been well investigated. Herein, we report...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2022.2136538 |
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| author | Pingchao Li Qian Wang Yizi He Chenchen Yang Zhengyuan Zhang Zijian Liu Bo Liu Li Yin Yilan Cui Peiyu Hu Yichu Liu Pingqian Zheng Wei Wang Linbing Qu Caijun Sun Suhua Guan Liqiang Feng Ling Chen |
| author_facet | Pingchao Li Qian Wang Yizi He Chenchen Yang Zhengyuan Zhang Zijian Liu Bo Liu Li Yin Yilan Cui Peiyu Hu Yichu Liu Pingqian Zheng Wei Wang Linbing Qu Caijun Sun Suhua Guan Liqiang Feng Ling Chen |
| author_sort | Pingchao Li |
| collection | DOAJ |
| description | Prolonged infection and possible evolution of SARS-CoV-2 in patients living with uncontrolled HIV-1 infection highlight the importance of an effective vaccination regimen, yet the immunogenicity of COVID-19 vaccines and predictive immune biomarkers have not been well investigated. Herein, we report that the magnitude and persistence of antibody and cell-mediated immunity (CMI) elicited by an Ad5-vectored COVID-19 vaccine are impaired in SIV-infected macaques with high viral loads (> 105 genome copies per ml plasma, SIVhi) but not in macaques with low viral loads (< 105, SIVlow). After a second vaccination, the immune responses are robustly enhanced in all uninfected and SIVlow macaques. These responses also show a moderate increase in 70% SIVhi macaques but decline sharply soon after. Further analysis reveals that decreased antibody and CMI responses are associated with reduced circulating follicular helper T cell (TFH) counts and aberrant CD4/CD8 ratios, respectively, indicating that dysregulation of CD4+ T cells by SIV infection impairs the COVID-19 vaccine-induced immunity. Ad5-vectored COVID-19 vaccine shows no impact on SIV loads or SIV-specific CMI responses. Our study underscores the necessity of frequent booster vaccinations in HIV-infected patients and provides indicative biomarkers for predicting vaccination effectiveness in these patients. |
| format | Article |
| id | doaj-art-5e2cea3b05bc4148a9970b6665fd1f73 |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-5e2cea3b05bc4148a9970b6665fd1f732025-08-20T02:30:45ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112110.1080/22221751.2022.2136538Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaquesPingchao Li0Qian Wang1Yizi He2Chenchen Yang3Zhengyuan Zhang4Zijian Liu5Bo Liu6Li Yin7Yilan Cui8Peiyu Hu9Yichu Liu10Pingqian Zheng11Wei Wang12Linbing Qu13Caijun Sun14Suhua Guan15Liqiang Feng16Ling Chen17State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, People’s Republic of ChinaState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of ChinaState Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, People’s Republic of ChinaGuangzhou nBiomed Ltd., Guangzhou, People’s Republic of ChinaState Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, People’s Republic of ChinaState Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, People’s Republic of ChinaGuangzhou nBiomed Ltd., Guangzhou, People’s Republic of ChinaState Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, People’s Republic of ChinaState Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, People’s Republic of ChinaGuangzhou Laboratory & Bioland Laboratory, Guangzhou, People’s Republic of ChinaState Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, People’s Republic of ChinaGuangzhou Laboratory & Bioland Laboratory, Guangzhou, People’s Republic of ChinaGuangzhou Laboratory & Bioland Laboratory, Guangzhou, People’s Republic of ChinaState Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, People’s Republic of ChinaState Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, People’s Republic of ChinaGuangzhou nBiomed Ltd., Guangzhou, People’s Republic of ChinaState Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, People’s Republic of ChinaState Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, People’s Republic of ChinaProlonged infection and possible evolution of SARS-CoV-2 in patients living with uncontrolled HIV-1 infection highlight the importance of an effective vaccination regimen, yet the immunogenicity of COVID-19 vaccines and predictive immune biomarkers have not been well investigated. Herein, we report that the magnitude and persistence of antibody and cell-mediated immunity (CMI) elicited by an Ad5-vectored COVID-19 vaccine are impaired in SIV-infected macaques with high viral loads (> 105 genome copies per ml plasma, SIVhi) but not in macaques with low viral loads (< 105, SIVlow). After a second vaccination, the immune responses are robustly enhanced in all uninfected and SIVlow macaques. These responses also show a moderate increase in 70% SIVhi macaques but decline sharply soon after. Further analysis reveals that decreased antibody and CMI responses are associated with reduced circulating follicular helper T cell (TFH) counts and aberrant CD4/CD8 ratios, respectively, indicating that dysregulation of CD4+ T cells by SIV infection impairs the COVID-19 vaccine-induced immunity. Ad5-vectored COVID-19 vaccine shows no impact on SIV loads or SIV-specific CMI responses. Our study underscores the necessity of frequent booster vaccinations in HIV-infected patients and provides indicative biomarkers for predicting vaccination effectiveness in these patients.https://www.tandfonline.com/doi/10.1080/22221751.2022.2136538COVID-19 vaccineimmunogenicityimmunodeficiencyHIVSIV infectionrhesus macaques |
| spellingShingle | Pingchao Li Qian Wang Yizi He Chenchen Yang Zhengyuan Zhang Zijian Liu Bo Liu Li Yin Yilan Cui Peiyu Hu Yichu Liu Pingqian Zheng Wei Wang Linbing Qu Caijun Sun Suhua Guan Liqiang Feng Ling Chen Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques Emerging Microbes and Infections COVID-19 vaccine immunogenicity immunodeficiency HIV SIV infection rhesus macaques |
| title | Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques |
| title_full | Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques |
| title_fullStr | Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques |
| title_full_unstemmed | Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques |
| title_short | Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques |
| title_sort | booster vaccination is required to elicit and maintain covid 19 vaccine induced immunity in siv infected macaques |
| topic | COVID-19 vaccine immunogenicity immunodeficiency HIV SIV infection rhesus macaques |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2022.2136538 |
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