Ferroptosis and Sterol Biosynthesis Dysregulation in Granulosa Cells of Patients with Diminished Ovarian Reserve

Ferroptosis and Sterol Biosynthesis Dysregulation in Granulosa Cells of Patients with Diminished Ovarian Reserve

Granulosa cell (GC) dysfunction contributes to diminished ovarian reserve (DOR). We collected GC and follicular fluid samples from the patients of normal ovarian reserve (NOR) and DOR. RNA-seq of GCs showed that cholesterol/sterol metabolism and biosynthesis and extracellular matrix organization wer...

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Bibliographic Details
Main Authors: Yang Yu, Yali Shan, Jiani Lu, Yexing Xian, Zhengshan Tang, Xinyu Guo, Yan Huang, Xin Ni
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Antioxidants
Subjects:
diminished ovarian reserve
granulosa cells
ferroptosis
cholesterol synthesis
steroid hormone synthesis
aromatase
Online Access:https://www.mdpi.com/2076-3921/14/6/749
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