UBE2D1 as a key biomarker in systemic juvenile idiopathic arthritis: a new perspective on diagnosis and disease activity assessment

Abstract Background Early diagnosis is crucial for reducing disability and improving long-term prognosis in patients with systemic Juvenile Idiopathic Arthritis (sJIA), but it remains a significant challenge. This study aims to identify non-invasive biomarkers with superior diagnostic efficacy for s...

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Main Authors:	Qiang Luo, Han Hao, Luo Xiwen, Xiang Qiu, Dawei Liu, Yun Liu, Fengning Li, Kening Lu, Xiya Luo, Chenxi Ma, Xiaodong Zhao, Yunfei An, Xuemei Tang
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	Arthritis Research & Therapy
Subjects:	Systemic juvenile idiopathic arthritis Single-cell RNA sequencing Consensus machine learning driven signatures UBE2D1 Nod-like receptor signaling pathways UBE2D1 complication map
Online Access:	https://doi.org/10.1186/s13075-025-03606-8
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UBE2D1 as a key biomarker in systemic juvenile idiopathic arthritis: a new perspective on diagnosis and disease activity assessment

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