T cell receptor repertoire characteristics both before and following immunotherapy correlate with clinical response in mesothelioma

T cell receptor repertoire characteristics both before and following immunotherapy correlate with clinical response in mesothelioma

Background Malignant pleural mesothelioma (MPM) is a highly lethal malignancy in need for new treatment options. Although immunotherapies have been shown to boost a tumor-specific immune response, not all patients respond and prognostic biomarkers are scarce. In this study, we determined the periphe...

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Main Authors: Niek de Vries, Joachim G J V Aerts, Paul L Klarenbeek, Heleen Vroman, Giulia Balzaretti, Robert A Belderbos, Menno van Nimwegen, Koen Bezemer, Robin Cornelissen, Ilse T G Niewold, Barbera D van Schaik, Antione H van Kampen, Rudi W Hendriks
Format: Article
Language:English
Published: BMJ Publishing Group 2020-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/8/1/e000251.full
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