Host restriction factors against porcine epidemic diarrhea virus: a mini-review
Abstract Porcine epidemic diarrhea is an acute contagious disease caused by porcine epidemic diarrhea virus (PEDV), which severely constrains the development of the global swine industry. Host restriction factors constitute a vital defensive barrier against viral infections, typically interacting wi...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | Veterinary Research |
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| Online Access: | https://doi.org/10.1186/s13567-025-01500-4 |
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| author | Hongqing Zheng Cunyi Qiu Haolun Tian Xiaofu Zhu Baoying Yin Zhiding Zhou Xuezhao Li Jingjing Zhao |
| author_facet | Hongqing Zheng Cunyi Qiu Haolun Tian Xiaofu Zhu Baoying Yin Zhiding Zhou Xuezhao Li Jingjing Zhao |
| author_sort | Hongqing Zheng |
| collection | DOAJ |
| description | Abstract Porcine epidemic diarrhea is an acute contagious disease caused by porcine epidemic diarrhea virus (PEDV), which severely constrains the development of the global swine industry. Host restriction factors constitute a vital defensive barrier against viral infections, typically interacting with viruses at specific stages of their replication process to disrupt it. Considering that traditional PEDV vaccines often struggle to effectively activate mucosal immunity in sows and thereby fail to provide reliable passive immunity to piglets via milk, this review focuses on the host restriction factors that play crucial roles in restricting PEDV infection and replication. The aim is to identify potential targets for the development of anti-PEDV drugs and offer insights for the exploration of novel vaccine adjuvants. |
| format | Article |
| id | doaj-art-5e1d8080dbcb49a79ee7bba76fe65b7d |
| institution | DOAJ |
| issn | 1297-9716 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Veterinary Research |
| spelling | doaj-art-5e1d8080dbcb49a79ee7bba76fe65b7d2025-08-20T02:49:33ZengBMCVeterinary Research1297-97162025-03-0156111010.1186/s13567-025-01500-4Host restriction factors against porcine epidemic diarrhea virus: a mini-reviewHongqing Zheng0Cunyi Qiu1Haolun Tian2Xiaofu Zhu3Baoying Yin4Zhiding Zhou5Xuezhao Li6Jingjing Zhao7Xianyang Polytechnic InstituteGansu Polytechnic College of Animal Husbandry & EngineeringNorthwest a&F UniversityXianyang Polytechnic InstituteXianyang Polytechnic InstituteKey Laboratory of Marine Animal Disease Prevention and Control, Dalian Ocean UniversityGansu Polytechnic College of Animal Husbandry & EngineeringDepartment of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of TechnologyAbstract Porcine epidemic diarrhea is an acute contagious disease caused by porcine epidemic diarrhea virus (PEDV), which severely constrains the development of the global swine industry. Host restriction factors constitute a vital defensive barrier against viral infections, typically interacting with viruses at specific stages of their replication process to disrupt it. Considering that traditional PEDV vaccines often struggle to effectively activate mucosal immunity in sows and thereby fail to provide reliable passive immunity to piglets via milk, this review focuses on the host restriction factors that play crucial roles in restricting PEDV infection and replication. The aim is to identify potential targets for the development of anti-PEDV drugs and offer insights for the exploration of novel vaccine adjuvants.https://doi.org/10.1186/s13567-025-01500-4PEDVswinehost restriction factorvirus–host interaction |
| spellingShingle | Hongqing Zheng Cunyi Qiu Haolun Tian Xiaofu Zhu Baoying Yin Zhiding Zhou Xuezhao Li Jingjing Zhao Host restriction factors against porcine epidemic diarrhea virus: a mini-review Veterinary Research PEDV swine host restriction factor virus–host interaction |
| title | Host restriction factors against porcine epidemic diarrhea virus: a mini-review |
| title_full | Host restriction factors against porcine epidemic diarrhea virus: a mini-review |
| title_fullStr | Host restriction factors against porcine epidemic diarrhea virus: a mini-review |
| title_full_unstemmed | Host restriction factors against porcine epidemic diarrhea virus: a mini-review |
| title_short | Host restriction factors against porcine epidemic diarrhea virus: a mini-review |
| title_sort | host restriction factors against porcine epidemic diarrhea virus a mini review |
| topic | PEDV swine host restriction factor virus–host interaction |
| url | https://doi.org/10.1186/s13567-025-01500-4 |
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