Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care Hospital
Background and Objectives. The drugs most commonly implicated in major potential interactions are those used in the day-to-day clinical management of elderly patients with chronic diseases. This study is planned to evaluate the profile of drug-drug interactions in the medications prescribed to elder...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2018/5728957 |
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| author | Varsha Shetty Mukta N. Chowta Nithyananda Chowta K Ashok Shenoy Ashwin Kamath Priyanka Kamath |
| author_facet | Varsha Shetty Mukta N. Chowta Nithyananda Chowta K Ashok Shenoy Ashwin Kamath Priyanka Kamath |
| author_sort | Varsha Shetty |
| collection | DOAJ |
| description | Background and Objectives. The drugs most commonly implicated in major potential interactions are those used in the day-to-day clinical management of elderly patients with chronic diseases. This study is planned to evaluate the profile of drug-drug interactions in the medications prescribed to elderly population and also to identify the possible predictors for potential drug-drug interactions in the elderly. Methods. This cross-sectional study included patients aged above 60 years with a minimum of two drugs in the prescriptions. Data were collected from medical prescriptions and patients' medical records. The data collected included demographic characteristics such as age, gender, height, weight, educational status, socioeconomic status, medical history, and medications prescribed. The prescriptions were analyzed for the potential drug interactions using Lexi-Interact™ Online, an online software to check drug-drug interactions. Results. A total of 209 patients were included in the study, among them 104 (49.8%) were males and 105 (50.2%) were females. The mean number of medications received was 6.53 ± 2.15 per prescription. Around 138 (66%) patients received more than six medications. The mean number of potential drug interactions seen in the prescription of these patients was 3.17 ± 2.78. Around 18.2% patients had more than five drug interactions. Major drug interactions were observed in 21.42% of cases. Around 3.02% of drug interactions belonged to risk category X, i.e., to be avoided. Logistic regression analysis showed that age above 70 years was associated with the presence of drug interactions. Increased number of medication was independently associated with the occurrence of drug interactions. The presence of drug interactions was not associated with increased number of comorbidities. Conclusion. A significant number of potential drug-drug interactions were seen in the prescriptions of elderly patients. Increasing age and polypharmacy were identified as the predictors of potential drug interactions. |
| format | Article |
| id | doaj-art-5e1891fea768425e82205a81b828b8c3 |
| institution | OA Journals |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-5e1891fea768425e82205a81b828b8c32025-08-20T02:06:00ZengWileyJournal of Aging Research2090-22042090-22122018-01-01201810.1155/2018/57289575728957Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care HospitalVarsha Shetty0Mukta N. Chowta1Nithyananda Chowta K2Ashok Shenoy3Ashwin Kamath4Priyanka Kamath5Department of Medicine and Pharmacology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Mangalore, IndiaDepartment of Medicine and Pharmacology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Mangalore, IndiaDepartment of Medicine and Pharmacology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Mangalore, IndiaDepartment of Medicine and Pharmacology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Mangalore, IndiaDepartment of Medicine and Pharmacology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Mangalore, IndiaDepartment of Medicine and Pharmacology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Mangalore, IndiaBackground and Objectives. The drugs most commonly implicated in major potential interactions are those used in the day-to-day clinical management of elderly patients with chronic diseases. This study is planned to evaluate the profile of drug-drug interactions in the medications prescribed to elderly population and also to identify the possible predictors for potential drug-drug interactions in the elderly. Methods. This cross-sectional study included patients aged above 60 years with a minimum of two drugs in the prescriptions. Data were collected from medical prescriptions and patients' medical records. The data collected included demographic characteristics such as age, gender, height, weight, educational status, socioeconomic status, medical history, and medications prescribed. The prescriptions were analyzed for the potential drug interactions using Lexi-Interact™ Online, an online software to check drug-drug interactions. Results. A total of 209 patients were included in the study, among them 104 (49.8%) were males and 105 (50.2%) were females. The mean number of medications received was 6.53 ± 2.15 per prescription. Around 138 (66%) patients received more than six medications. The mean number of potential drug interactions seen in the prescription of these patients was 3.17 ± 2.78. Around 18.2% patients had more than five drug interactions. Major drug interactions were observed in 21.42% of cases. Around 3.02% of drug interactions belonged to risk category X, i.e., to be avoided. Logistic regression analysis showed that age above 70 years was associated with the presence of drug interactions. Increased number of medication was independently associated with the occurrence of drug interactions. The presence of drug interactions was not associated with increased number of comorbidities. Conclusion. A significant number of potential drug-drug interactions were seen in the prescriptions of elderly patients. Increasing age and polypharmacy were identified as the predictors of potential drug interactions.http://dx.doi.org/10.1155/2018/5728957 |
| spellingShingle | Varsha Shetty Mukta N. Chowta Nithyananda Chowta K Ashok Shenoy Ashwin Kamath Priyanka Kamath Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care Hospital Journal of Aging Research |
| title | Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care Hospital |
| title_full | Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care Hospital |
| title_fullStr | Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care Hospital |
| title_full_unstemmed | Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care Hospital |
| title_short | Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care Hospital |
| title_sort | evaluation of potential drug drug interactions with medications prescribed to geriatric patients in a tertiary care hospital |
| url | http://dx.doi.org/10.1155/2018/5728957 |
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