Unravelling axonal transcriptional landscapes: insights from induced pluripotent stem cell-derived cortical neurons and implications for motor neuron degeneration

Unravelling axonal transcriptional landscapes: insights from induced pluripotent stem cell-derived cortical neurons and implications for motor neuron degeneration

Neuronal function and pathology are deeply influenced by the distinct molecular profiles of the axon and soma. Traditional studies have often overlooked these differences due to the technical challenges of compartment-specific analysis. In this study, we employ a robust RNA-sequencing approach, usin...

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Bibliographic Details
Main Authors: Jishu Xu, Michaela Hörner, Maike Nagel, Perwin Perhat, Milena Korneck, Marvin Noß, Stefan Hauser, Ludger Schoels, Jakob Admard, Nicolas Casadei, Rebecca Schuele
Format: Article
Language:English
Published: The Royal Society 2025-06-01
Series:Open Biology
Subjects:
axonal transcriptomics
transcription factors
axonal transport
kinesin
neurons
iPSC-derived neurons
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.250101
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