Functional genomic profiling of O-GlcNAc reveals its context-specific interplay with RNA polymerase II

Functional genomic profiling of O-GlcNAc reveals its context-specific interplay with RNA polymerase II

Abstract Background How reversible glycosylation of DNA-bound proteins acts on transcription remains scarcely understood. O-linked β-N-acetylglucosamine (O-GlcNAc) is the only known form of glycosylation modifying nuclear proteins, including RNA polymerase II (RNA Pol II) and many transcription fact...

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Bibliographic Details
Main Authors: Sofia Rucli, Nicolas Descostes, Yulia Ermakova, Urvashi Chitnavis, Jeanne Couturier, Ana Boskovic, Matthieu Boulard
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Genome Biology
Subjects:
O-linked β-N-acetylglucosamine
O-GlcNAc
OGT
Glycosylation
Transcription
Promoter
Online Access:https://doi.org/10.1186/s13059-025-03537-2
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