Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans?
In the past 25 years, the development of an effective malaria vaccine has become one of the biggest riddles in the biomedical sciences. Experimental data using animal infection models demonstrated that it is possible to induce protective immunity against different stages of malaria parasites. Noneth...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2011/965369 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554084078452736 |
|---|---|
| author | Daniel Y. Bargieri Irene S. Soares Fabio T. M. Costa Catarina J. Braga Luis C. S. Ferreira Mauricio M. Rodrigues |
| author_facet | Daniel Y. Bargieri Irene S. Soares Fabio T. M. Costa Catarina J. Braga Luis C. S. Ferreira Mauricio M. Rodrigues |
| author_sort | Daniel Y. Bargieri |
| collection | DOAJ |
| description | In the past 25 years, the development of an effective malaria vaccine has become one of the biggest riddles in the biomedical sciences. Experimental data using animal infection models demonstrated that it is possible to induce protective immunity against different stages of malaria parasites. Nonetheless, the vast body of knowledge has generated disappointments when submitted to clinical conditions and presently a single antigen formulation has progressed to the point where it may be translated into a human vaccine. In parallel, new means to increase the protective effects of antigens in general have been pursued and depicted, such as the use of bacterial flagellins as carriers/adjuvants. Flagellins activate pathways in the innate immune system of both mice and humans. The recent report of the first Phase I clinical trial of a vaccine containing a Salmonella flagellin as carrier/adjuvant may fuel the use of these proteins in vaccine formulations. Herein, we review the studies on the use of recombinant flagellins as vaccine adjuvants with malarial antigens in the light of the current state of the art of malaria vaccine development. The available information indicates that bacterial flagellins should be seriously considered for malaria vaccine formulations to the development of effective human vaccines. |
| format | Article |
| id | doaj-art-5dffd6fad3fc4dfbbd222c60512d7bde |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-5dffd6fad3fc4dfbbd222c60512d7bde2025-02-03T05:52:19ZengWileyJournal of Parasitology Research2090-00232090-00312011-01-01201110.1155/2011/965369965369Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans?Daniel Y. Bargieri0Irene S. Soares1Fabio T. M. Costa2Catarina J. Braga3Luis C. S. Ferreira4Mauricio M. Rodrigues5Centro de Terapia Celular e Molecular (CTCMol), Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Mirassol 207, São Paulo 04044-010, SP, BrazilDepartamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Avenida Prof. Lineu Prestes 580, São Paulo 05508-900, SP, BrazilDepartamento de Genética, Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas, Rua Monteiro Lobato, 255, Campinas 13083-970, SP, BrazilDepartamento de Microbiologia do Instituto de Ciências Biomédicas Universidade de São Paulo, Avenida Prof. Lineu Prestes, 1374, São Paulo 05508-900, SP, BrazilDepartamento de Microbiologia do Instituto de Ciências Biomédicas Universidade de São Paulo, Avenida Prof. Lineu Prestes, 1374, São Paulo 05508-900, SP, BrazilCentro de Terapia Celular e Molecular (CTCMol), Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Mirassol 207, São Paulo 04044-010, SP, BrazilIn the past 25 years, the development of an effective malaria vaccine has become one of the biggest riddles in the biomedical sciences. Experimental data using animal infection models demonstrated that it is possible to induce protective immunity against different stages of malaria parasites. Nonetheless, the vast body of knowledge has generated disappointments when submitted to clinical conditions and presently a single antigen formulation has progressed to the point where it may be translated into a human vaccine. In parallel, new means to increase the protective effects of antigens in general have been pursued and depicted, such as the use of bacterial flagellins as carriers/adjuvants. Flagellins activate pathways in the innate immune system of both mice and humans. The recent report of the first Phase I clinical trial of a vaccine containing a Salmonella flagellin as carrier/adjuvant may fuel the use of these proteins in vaccine formulations. Herein, we review the studies on the use of recombinant flagellins as vaccine adjuvants with malarial antigens in the light of the current state of the art of malaria vaccine development. The available information indicates that bacterial flagellins should be seriously considered for malaria vaccine formulations to the development of effective human vaccines.http://dx.doi.org/10.1155/2011/965369 |
| spellingShingle | Daniel Y. Bargieri Irene S. Soares Fabio T. M. Costa Catarina J. Braga Luis C. S. Ferreira Mauricio M. Rodrigues Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans? Journal of Parasitology Research |
| title | Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans? |
| title_full | Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans? |
| title_fullStr | Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans? |
| title_full_unstemmed | Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans? |
| title_short | Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans? |
| title_sort | malaria vaccine development are bacterial flagellin fusion proteins the bridge between mouse and humans |
| url | http://dx.doi.org/10.1155/2011/965369 |
| work_keys_str_mv | AT danielybargieri malariavaccinedevelopmentarebacterialflagellinfusionproteinsthebridgebetweenmouseandhumans AT irenessoares malariavaccinedevelopmentarebacterialflagellinfusionproteinsthebridgebetweenmouseandhumans AT fabiotmcosta malariavaccinedevelopmentarebacterialflagellinfusionproteinsthebridgebetweenmouseandhumans AT catarinajbraga malariavaccinedevelopmentarebacterialflagellinfusionproteinsthebridgebetweenmouseandhumans AT luiscsferreira malariavaccinedevelopmentarebacterialflagellinfusionproteinsthebridgebetweenmouseandhumans AT mauriciomrodrigues malariavaccinedevelopmentarebacterialflagellinfusionproteinsthebridgebetweenmouseandhumans |