The impact of dietary patterns on gut microbiota for the primary and secondary prevention of cardiovascular disease: a systematic review
Abstract Background Previous studies found that it is promising to achieve the protective effects of dietary patterns on cardiovascular health through the modulation of gut microbiota. However, conflicting findings have been reported on how dietary patterns impact gut microbiota in individuals eithe...
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2025-01-01
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| author | Junwen Yu Yue Wu Zheng Zhu Hongzhou Lu |
| author_facet | Junwen Yu Yue Wu Zheng Zhu Hongzhou Lu |
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| description | Abstract Background Previous studies found that it is promising to achieve the protective effects of dietary patterns on cardiovascular health through the modulation of gut microbiota. However, conflicting findings have been reported on how dietary patterns impact gut microbiota in individuals either established or at risk of cardiovascular disease (CVD). Our systematic review aimed to explore the effect of dietary patterns on gut microbiota composition and on risk factors for CVD in these populations. Methods We systematically searched seven databases, including PubMed/MEDLINE, MEDLINE (Ovid), Embase (Ovid), CINHAL (EBSCO), Web of Science, CNKI (Chinese), and Wanfang (Chinese), covering literature from inception to October 2024. Studies were included if they focused on adults aged 18 years and older with CVD or at least two CVD risk factors, implemented dietary pattern interventions, and incorporated outcomes related to microbiome analysis. The risk of bias for included studies was assessed using the revised Cochrane risk of bias tool (RoB2) for randomized trials and the Risk Of Bias In Non-randomised Studies of Interventions (ROBINS-I) for non-randomized studies. Changes in the relative abundance of the gut microbiome were summarized at various taxonomic levels, including phylum, class, order, family, genus, and species. Random-effects meta-analysis was conducted to analyze the mean difference in cardiometabolic parameters pre- and post-intervention. Results Nineteen studies were identified, including 17 RCT and two self-controlled trails. Risk of bias across the studies was mixed but mainly identified as low and unclear. The most frequently reported increased taxa were Faecalibacterium (N = 8) with plant-rich diets, Bacteroides (N = 3) with restrictive diets, and Ruminococcaceae UCG 005 and Alistipes (N = 9) with the polyphenol-rich diets. The most frequently reported decreased taxa were Parabacteroides (N = 7) with plant-rich diets, Roseburia (N = 3) with restrictive diets, and Ruminococcus gauvreauii group (N = 6) with the polyphenol-rich diets. Plant-rich diets showed a significant decrease in total cholesterol (TC) with a mean difference of -6.77 (95% CI, -12.36 to -2.58; I 2 = 84.7%), while restrictive diets showed a significant decrease in triglycerides (TG) of -22.12 (95% CI, -36.05 to -8.19; I 2 = 98.4%). Conclusions Different dietary patterns showed distinct impacts on gut microbiota composition. Plant-rich diets promoted the proliferation of butyrate-producing bacteria, suggesting promising prospects for modulating gut microbiota and butyrate production through dietary interventions to enhance cardiovascular health. Further research is warranted to investigate the long-term effects of dietary patterns on clinical endpoints, such as CVD events or mortality. Review registration Registration number: CRD42024507660 |
| format | Article |
| id | doaj-art-5df4ed3e6d7343e9b0751344af6a195d |
| institution | Kabale University |
| issn | 1475-2891 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-5df4ed3e6d7343e9b0751344af6a195d2025-02-02T12:09:56ZengBMCNutrition Journal1475-28912025-01-0124111710.1186/s12937-024-01060-xThe impact of dietary patterns on gut microbiota for the primary and secondary prevention of cardiovascular disease: a systematic reviewJunwen Yu0Yue Wu1Zheng Zhu2Hongzhou Lu3School of Nursing, Fudan UniversitySchool of Nursing, Fudan UniversitySchool of Nursing, Fudan UniversityDepartment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, the Third People’s Hospital of ShenzhenAbstract Background Previous studies found that it is promising to achieve the protective effects of dietary patterns on cardiovascular health through the modulation of gut microbiota. However, conflicting findings have been reported on how dietary patterns impact gut microbiota in individuals either established or at risk of cardiovascular disease (CVD). Our systematic review aimed to explore the effect of dietary patterns on gut microbiota composition and on risk factors for CVD in these populations. Methods We systematically searched seven databases, including PubMed/MEDLINE, MEDLINE (Ovid), Embase (Ovid), CINHAL (EBSCO), Web of Science, CNKI (Chinese), and Wanfang (Chinese), covering literature from inception to October 2024. Studies were included if they focused on adults aged 18 years and older with CVD or at least two CVD risk factors, implemented dietary pattern interventions, and incorporated outcomes related to microbiome analysis. The risk of bias for included studies was assessed using the revised Cochrane risk of bias tool (RoB2) for randomized trials and the Risk Of Bias In Non-randomised Studies of Interventions (ROBINS-I) for non-randomized studies. Changes in the relative abundance of the gut microbiome were summarized at various taxonomic levels, including phylum, class, order, family, genus, and species. Random-effects meta-analysis was conducted to analyze the mean difference in cardiometabolic parameters pre- and post-intervention. Results Nineteen studies were identified, including 17 RCT and two self-controlled trails. Risk of bias across the studies was mixed but mainly identified as low and unclear. The most frequently reported increased taxa were Faecalibacterium (N = 8) with plant-rich diets, Bacteroides (N = 3) with restrictive diets, and Ruminococcaceae UCG 005 and Alistipes (N = 9) with the polyphenol-rich diets. The most frequently reported decreased taxa were Parabacteroides (N = 7) with plant-rich diets, Roseburia (N = 3) with restrictive diets, and Ruminococcus gauvreauii group (N = 6) with the polyphenol-rich diets. Plant-rich diets showed a significant decrease in total cholesterol (TC) with a mean difference of -6.77 (95% CI, -12.36 to -2.58; I 2 = 84.7%), while restrictive diets showed a significant decrease in triglycerides (TG) of -22.12 (95% CI, -36.05 to -8.19; I 2 = 98.4%). Conclusions Different dietary patterns showed distinct impacts on gut microbiota composition. Plant-rich diets promoted the proliferation of butyrate-producing bacteria, suggesting promising prospects for modulating gut microbiota and butyrate production through dietary interventions to enhance cardiovascular health. Further research is warranted to investigate the long-term effects of dietary patterns on clinical endpoints, such as CVD events or mortality. Review registration Registration number: CRD42024507660https://doi.org/10.1186/s12937-024-01060-xCardiometabolicCardiovascular diseaseDietary patternGut microbiotaSystematic review |
| spellingShingle | Junwen Yu Yue Wu Zheng Zhu Hongzhou Lu The impact of dietary patterns on gut microbiota for the primary and secondary prevention of cardiovascular disease: a systematic review Nutrition Journal Cardiometabolic Cardiovascular disease Dietary pattern Gut microbiota Systematic review |
| title | The impact of dietary patterns on gut microbiota for the primary and secondary prevention of cardiovascular disease: a systematic review |
| title_full | The impact of dietary patterns on gut microbiota for the primary and secondary prevention of cardiovascular disease: a systematic review |
| title_fullStr | The impact of dietary patterns on gut microbiota for the primary and secondary prevention of cardiovascular disease: a systematic review |
| title_full_unstemmed | The impact of dietary patterns on gut microbiota for the primary and secondary prevention of cardiovascular disease: a systematic review |
| title_short | The impact of dietary patterns on gut microbiota for the primary and secondary prevention of cardiovascular disease: a systematic review |
| title_sort | impact of dietary patterns on gut microbiota for the primary and secondary prevention of cardiovascular disease a systematic review |
| topic | Cardiometabolic Cardiovascular disease Dietary pattern Gut microbiota Systematic review |
| url | https://doi.org/10.1186/s12937-024-01060-x |
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