Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions
Leptin is involved in the endocrine control of energy expenditure and body weight regulation. Previous studies emphasize a relationship between hypoxic states and leptin concentrations. The aim of this study was to investigate the effects of acute hypoxia on leptin concentrations in healthy subjects...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2009/270698 |
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| author | Andre Schmoller Michaela Voss Hartmut Gehring Sebastian Rudolf Ulrich Schweiger Bernd Schultes Kerstin M. Oltmanns |
| author_facet | Andre Schmoller Michaela Voss Hartmut Gehring Sebastian Rudolf Ulrich Schweiger Bernd Schultes Kerstin M. Oltmanns |
| author_sort | Andre Schmoller |
| collection | DOAJ |
| description | Leptin is involved in the endocrine control of energy expenditure and body weight regulation. Previous studies emphasize a relationship between hypoxic states and leptin concentrations. The aim of this study was to investigate the effects of acute hypoxia on leptin concentrations in healthy subjects. We examined 14 healthy men. Hypoxic conditions were induced by decreasing oxygen saturation to 75% for 30 minutes. Plasma leptin concentrations were determined at baseline, after 3 hours of euglycemic clamping, during hypoxia, and repeatedly the following 2.5 hours thereafter. Our results show an increase of plasma leptin concentrations in the course of 6 hours of hyperinsulinemic-euglycemic clamping which may reflect diurnal rhythmicity. Notwithstanding, there was no difference between levels of leptin in the hypoxic and the normoxic condition (𝑃=.2). Since we did not find any significant changes in leptin responses upon hypoxia, plasma leptin levels do not seem to be affected by short hypoxic episodes of moderate degree. |
| format | Article |
| id | doaj-art-5df1cf214e8e4b67b2412138db8098ef |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-5df1cf214e8e4b67b2412138db8098ef2025-08-20T02:06:03ZengWileyInternational Journal of Endocrinology1687-83371687-83452009-01-01200910.1155/2009/270698270698Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp ConditionsAndre Schmoller0Michaela Voss1Hartmut Gehring2Sebastian Rudolf3Ulrich Schweiger4Bernd Schultes5Kerstin M. Oltmanns6Department of Psychiatry and Psychotherapy, University of Luebeck, D-23538 Luebeck, GermanyDepartment of Psychiatry and Psychotherapy, University of Luebeck, D-23538 Luebeck, GermanyDepartment of Anaesthesiology, University of Luebeck, D-23538 Luebeck, GermanyDepartment of Psychiatry and Psychotherapy, University of Luebeck, D-23538 Luebeck, GermanyDepartment of Psychiatry and Psychotherapy, University of Luebeck, D-23538 Luebeck, GermanyInterdisciplinary Obesity Center, St. Gallen, CH-9400 Rorschach, SwitzerlandDepartment of Psychiatry and Psychotherapy, University of Luebeck, D-23538 Luebeck, GermanyLeptin is involved in the endocrine control of energy expenditure and body weight regulation. Previous studies emphasize a relationship between hypoxic states and leptin concentrations. The aim of this study was to investigate the effects of acute hypoxia on leptin concentrations in healthy subjects. We examined 14 healthy men. Hypoxic conditions were induced by decreasing oxygen saturation to 75% for 30 minutes. Plasma leptin concentrations were determined at baseline, after 3 hours of euglycemic clamping, during hypoxia, and repeatedly the following 2.5 hours thereafter. Our results show an increase of plasma leptin concentrations in the course of 6 hours of hyperinsulinemic-euglycemic clamping which may reflect diurnal rhythmicity. Notwithstanding, there was no difference between levels of leptin in the hypoxic and the normoxic condition (𝑃=.2). Since we did not find any significant changes in leptin responses upon hypoxia, plasma leptin levels do not seem to be affected by short hypoxic episodes of moderate degree.http://dx.doi.org/10.1155/2009/270698 |
| spellingShingle | Andre Schmoller Michaela Voss Hartmut Gehring Sebastian Rudolf Ulrich Schweiger Bernd Schultes Kerstin M. Oltmanns Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions International Journal of Endocrinology |
| title | Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions |
| title_full | Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions |
| title_fullStr | Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions |
| title_full_unstemmed | Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions |
| title_short | Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions |
| title_sort | short hypoxia does not affect plasma leptin in healthy men under euglycemic clamp conditions |
| url | http://dx.doi.org/10.1155/2009/270698 |
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