Regulation of the Immune System in Aging: Focus on Epigenetic Mechanisms
Epigenetics studies processes leading to changes in the activity of genes without changing the DNA sequence. Epigenetic mechanisms, such as DNA methylation and histone modifications, are formed during embryonic development, and epigenetic profiles are stably inherited in mitosis, providing cell diff...
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| Language: | Russian |
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SINAPS LLC
2022-02-01
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| Series: | Архивъ внутренней медицины |
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| Online Access: | https://www.medarhive.ru/jour/article/view/1372 |
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| author | K. A. Aitbaev I. T. Murkamilov Zh. A. Murkamilova I. O. Kudaibergenova F. A. Yusupov |
| author_facet | K. A. Aitbaev I. T. Murkamilov Zh. A. Murkamilova I. O. Kudaibergenova F. A. Yusupov |
| author_sort | K. A. Aitbaev |
| collection | DOAJ |
| description | Epigenetics studies processes leading to changes in the activity of genes without changing the DNA sequence. Epigenetic mechanisms, such as DNA methylation and histone modifications, are formed during embryonic development, and epigenetic profiles are stably inherited in mitosis, providing cell differentiation and their further fate in the development process. Under the influence of internal and external factors such as metabolic profile, hormones, nutrition, drugs, smoking and stress, epigenetic mechanisms are actively modulated and, in this sense, a lifestyle can significantly affect the epigenome, and consequently, the gene expression profile and function of cells. It is shown that the development and function of cells of both congenital and adaptive immune systems are also regulated by epigenetic mechanisms, and negative epigenetic changes are a distinctive feature of aging and cancer. Given these data, it can be assumed that age-related changes in the profile of epigenetic labels can lead to a decrease in immune function and contribute to an increase in morbidity in the elderly. Therefore, to ensure healthy aging, better understanding of how to avoid epigenetic changes that are associated with aging of the immune system is needed. In this review, we tried to generalize the latest achievements in this field of research and consider the possibility of using them for diagnosis, prevention and treatment of diseases. |
| format | Article |
| id | doaj-art-5dea6f2f3c5e4bc9957a042db1f2ebbe |
| institution | Kabale University |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| publishDate | 2022-02-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj-art-5dea6f2f3c5e4bc9957a042db1f2ebbe2025-08-20T04:00:01ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642022-02-01121354410.20514/2226-6704-2022-12-1-35-44876Regulation of the Immune System in Aging: Focus on Epigenetic MechanismsK. A. Aitbaev0I. T. Murkamilov1Zh. A. Murkamilova2I. O. Kudaibergenova3F. A. Yusupov4Scientific and research Institute of molecular biology and medicineI. K. Akhunbaev Kyrgyz State Medical Academy; SEI HPE Kyrgyz Russian Slavic UniversityIlkhom T. MurkamilovSEI HPE Kyrgyz Russian Slavic UniversityКыргызская государственная медицинская академия имени И. К. АхунбаеваOsh State UniversityEpigenetics studies processes leading to changes in the activity of genes without changing the DNA sequence. Epigenetic mechanisms, such as DNA methylation and histone modifications, are formed during embryonic development, and epigenetic profiles are stably inherited in mitosis, providing cell differentiation and their further fate in the development process. Under the influence of internal and external factors such as metabolic profile, hormones, nutrition, drugs, smoking and stress, epigenetic mechanisms are actively modulated and, in this sense, a lifestyle can significantly affect the epigenome, and consequently, the gene expression profile and function of cells. It is shown that the development and function of cells of both congenital and adaptive immune systems are also regulated by epigenetic mechanisms, and negative epigenetic changes are a distinctive feature of aging and cancer. Given these data, it can be assumed that age-related changes in the profile of epigenetic labels can lead to a decrease in immune function and contribute to an increase in morbidity in the elderly. Therefore, to ensure healthy aging, better understanding of how to avoid epigenetic changes that are associated with aging of the immune system is needed. In this review, we tried to generalize the latest achievements in this field of research and consider the possibility of using them for diagnosis, prevention and treatment of diseases.https://www.medarhive.ru/jour/article/view/1372immune agingepigeneticsdna methylationhistone modificationsenvironmentage-related diseases |
| spellingShingle | K. A. Aitbaev I. T. Murkamilov Zh. A. Murkamilova I. O. Kudaibergenova F. A. Yusupov Regulation of the Immune System in Aging: Focus on Epigenetic Mechanisms Архивъ внутренней медицины immune aging epigenetics dna methylation histone modifications environment age-related diseases |
| title | Regulation of the Immune System in Aging: Focus on Epigenetic Mechanisms |
| title_full | Regulation of the Immune System in Aging: Focus on Epigenetic Mechanisms |
| title_fullStr | Regulation of the Immune System in Aging: Focus on Epigenetic Mechanisms |
| title_full_unstemmed | Regulation of the Immune System in Aging: Focus on Epigenetic Mechanisms |
| title_short | Regulation of the Immune System in Aging: Focus on Epigenetic Mechanisms |
| title_sort | regulation of the immune system in aging focus on epigenetic mechanisms |
| topic | immune aging epigenetics dna methylation histone modifications environment age-related diseases |
| url | https://www.medarhive.ru/jour/article/view/1372 |
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