Molecular regulatory mechanism of LILRB4 in the immune response
Immune diseases are caused by the imbalance of immune regulation. This imbalance is regulated by many factors, both negative and positive. Leukocyte immunoglobulin-like receptor B4 (LILRB4) is a member of leukocyte immunoglobulin-like receptors (LILRs). LILRs are expressed constitutively on the surf...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2023-02-01
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| Series: | Central European Journal of Immunology |
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| Online Access: | https://www.termedia.pl/Molecular-regulatory-mechanism-of-LILRB4-in-the-immune-response,10,50171,1,1.html |
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| author | Haiyin Liu Jun Yang Jing Zhang Peiyue Zhang Mengting Zhang Chaojun Yang Li Liu Cuiyuan Huang Wei Wang Yuhong Zhai Jian Yang |
| author_facet | Haiyin Liu Jun Yang Jing Zhang Peiyue Zhang Mengting Zhang Chaojun Yang Li Liu Cuiyuan Huang Wei Wang Yuhong Zhai Jian Yang |
| author_sort | Haiyin Liu |
| collection | DOAJ |
| description | Immune diseases are caused by the imbalance of immune regulation. This imbalance is regulated by many factors, both negative and positive. Leukocyte immunoglobulin-like receptor B4 (LILRB4) is a member of leukocyte immunoglobulin-like receptors (LILRs). LILRs are expressed constitutively on the surface of multiple immune cells which associate with membrane adaptors to signal through multi- ple cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) or immunoreceptor tyro-sine-based activation motifs (ITAMs). Through ITIM, LILRB4 could recruit the src homology domain type-2-containing tyrosine phosphatase 1 or 2 (SHP-1 or SHP-2) into the cell membrane. In addition, many factors can induce the expression of LILRB4, such as vitamin D, interferon and so on. Studies have demonstrated that LILRB4 had a negative regulatory role in various of immune diseases. The present review intends to expound the structure and function of LILRB4, as well as its regulators and receptors in the immune cells, so as to provide a theoretical basis for immune disease therapy. |
| format | Article |
| id | doaj-art-5de7ce457e474c77998fa1e7b8d25408 |
| institution | OA Journals |
| issn | 1426-3912 1644-4124 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Central European Journal of Immunology |
| spelling | doaj-art-5de7ce457e474c77998fa1e7b8d254082025-08-20T02:09:25ZengTermedia Publishing HouseCentral European Journal of Immunology1426-39121644-41242023-02-01481434710.5114/ceji.2023.12523850171Molecular regulatory mechanism of LILRB4 in the immune responseHaiyin LiuJun YangJing ZhangPeiyue ZhangMengting ZhangChaojun YangLi LiuCuiyuan HuangWei WangYuhong ZhaiJian YangImmune diseases are caused by the imbalance of immune regulation. This imbalance is regulated by many factors, both negative and positive. Leukocyte immunoglobulin-like receptor B4 (LILRB4) is a member of leukocyte immunoglobulin-like receptors (LILRs). LILRs are expressed constitutively on the surface of multiple immune cells which associate with membrane adaptors to signal through multi- ple cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) or immunoreceptor tyro-sine-based activation motifs (ITAMs). Through ITIM, LILRB4 could recruit the src homology domain type-2-containing tyrosine phosphatase 1 or 2 (SHP-1 or SHP-2) into the cell membrane. In addition, many factors can induce the expression of LILRB4, such as vitamin D, interferon and so on. Studies have demonstrated that LILRB4 had a negative regulatory role in various of immune diseases. The present review intends to expound the structure and function of LILRB4, as well as its regulators and receptors in the immune cells, so as to provide a theoretical basis for immune disease therapy.https://www.termedia.pl/Molecular-regulatory-mechanism-of-LILRB4-in-the-immune-response,10,50171,1,1.htmllilrb4 shp-1 immune disease molecular mechanism |
| spellingShingle | Haiyin Liu Jun Yang Jing Zhang Peiyue Zhang Mengting Zhang Chaojun Yang Li Liu Cuiyuan Huang Wei Wang Yuhong Zhai Jian Yang Molecular regulatory mechanism of LILRB4 in the immune response Central European Journal of Immunology lilrb4 shp-1 immune disease molecular mechanism |
| title | Molecular regulatory mechanism of LILRB4 in the immune response |
| title_full | Molecular regulatory mechanism of LILRB4 in the immune response |
| title_fullStr | Molecular regulatory mechanism of LILRB4 in the immune response |
| title_full_unstemmed | Molecular regulatory mechanism of LILRB4 in the immune response |
| title_short | Molecular regulatory mechanism of LILRB4 in the immune response |
| title_sort | molecular regulatory mechanism of lilrb4 in the immune response |
| topic | lilrb4 shp-1 immune disease molecular mechanism |
| url | https://www.termedia.pl/Molecular-regulatory-mechanism-of-LILRB4-in-the-immune-response,10,50171,1,1.html |
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