Inflammatory Myofibroblastic Tumour of the Skull Base
Inflammatory myofibroblastic tumors (IMTs) are rare benign clinical and pathological entities. IMTs have been described in the lungs, abdomen, retroperitoneum, and extremities but rarely in the head and neck region. A 38-year-old man presented with headache, right exophthalmia, and right 6th nerve p...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Otolaryngology |
| Online Access: | http://dx.doi.org/10.1155/2013/103646 |
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| author | Jean-Philippe Maire Sandrine Eimer François San Galli Valérie Franco-Vidal Sigolène Galland-Girodet Aymeri Huchet Vincent Darrouzet |
| author_facet | Jean-Philippe Maire Sandrine Eimer François San Galli Valérie Franco-Vidal Sigolène Galland-Girodet Aymeri Huchet Vincent Darrouzet |
| author_sort | Jean-Philippe Maire |
| collection | DOAJ |
| description | Inflammatory myofibroblastic tumors (IMTs) are rare benign clinical and pathological entities. IMTs have been described in the lungs, abdomen, retroperitoneum, and extremities but rarely in the head and neck region. A 38-year-old man presented with headache, right exophthalmia, and right 6th nerve palsy. A CT scan revealed enlargement of the right cavernous sinus and osteolytic lesions of the right sphenoid and clivus. MR imaging showed a large tumor of the skull base which was invading the sella turcica, right cavernous sinus, and sphenoidal sinus. A biopsy was performed and revealed an IMT. Corticosteroids were given for 3 months but were inefficient. In the framework of our pluridisciplinary consultation, fractionated conformal radiotherapy (FRT) was indicated at a low dose; 20 Gy in 10 fractions of 2 Gy over 12 days were delivered. Clinical response was complete 3 months after FRT. Radiological response was subtotal 6 months after FRT. Two years later, the patient is well. |
| format | Article |
| id | doaj-art-5de554e710974574be8dd95fe84ce6c6 |
| institution | OA Journals |
| issn | 2090-6765 2090-6773 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Otolaryngology |
| spelling | doaj-art-5de554e710974574be8dd95fe84ce6c62025-08-20T02:06:03ZengWileyCase Reports in Otolaryngology2090-67652090-67732013-01-01201310.1155/2013/103646103646Inflammatory Myofibroblastic Tumour of the Skull BaseJean-Philippe Maire0Sandrine Eimer1François San Galli2Valérie Franco-Vidal3Sigolène Galland-Girodet4Aymeri Huchet5Vincent Darrouzet6Department of Radiation Oncology, Saint-André University Hospital, University Bordeaux Segalen, 33076 Bordeaux, FranceDepartment of Pathology, Pellegrin University Hospital, University Bordeaux Segalen, Bordeaux, FranceDepartment of Neurosurgery A, Pellegrin University Hospital, University Bordeaux Segalen, Bordeaux, FranceDepartment of Otolaryngology and Skull Base Surgery, Pellegrin University Hospital, University Bordeaux Segalen, Bordeaux, FranceDepartment of Radiation Oncology, Saint-André University Hospital, University Bordeaux Segalen, 33076 Bordeaux, FranceDepartment of Radiation Oncology, Saint-André University Hospital, University Bordeaux Segalen, 33076 Bordeaux, FranceDepartment of Otolaryngology and Skull Base Surgery, Pellegrin University Hospital, University Bordeaux Segalen, Bordeaux, FranceInflammatory myofibroblastic tumors (IMTs) are rare benign clinical and pathological entities. IMTs have been described in the lungs, abdomen, retroperitoneum, and extremities but rarely in the head and neck region. A 38-year-old man presented with headache, right exophthalmia, and right 6th nerve palsy. A CT scan revealed enlargement of the right cavernous sinus and osteolytic lesions of the right sphenoid and clivus. MR imaging showed a large tumor of the skull base which was invading the sella turcica, right cavernous sinus, and sphenoidal sinus. A biopsy was performed and revealed an IMT. Corticosteroids were given for 3 months but were inefficient. In the framework of our pluridisciplinary consultation, fractionated conformal radiotherapy (FRT) was indicated at a low dose; 20 Gy in 10 fractions of 2 Gy over 12 days were delivered. Clinical response was complete 3 months after FRT. Radiological response was subtotal 6 months after FRT. Two years later, the patient is well.http://dx.doi.org/10.1155/2013/103646 |
| spellingShingle | Jean-Philippe Maire Sandrine Eimer François San Galli Valérie Franco-Vidal Sigolène Galland-Girodet Aymeri Huchet Vincent Darrouzet Inflammatory Myofibroblastic Tumour of the Skull Base Case Reports in Otolaryngology |
| title | Inflammatory Myofibroblastic Tumour of the Skull Base |
| title_full | Inflammatory Myofibroblastic Tumour of the Skull Base |
| title_fullStr | Inflammatory Myofibroblastic Tumour of the Skull Base |
| title_full_unstemmed | Inflammatory Myofibroblastic Tumour of the Skull Base |
| title_short | Inflammatory Myofibroblastic Tumour of the Skull Base |
| title_sort | inflammatory myofibroblastic tumour of the skull base |
| url | http://dx.doi.org/10.1155/2013/103646 |
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