Coffee consumption and risk of breast cancer: A Mendelian randomization study.
<h4>Background</h4>Observational studies have reported either null or weak protective associations for coffee consumption and risk of breast cancer.<h4>Methods</h4>We conducted a two-sample Mendelian randomization (MR) analysis to evaluate the relationship between coffee cons...
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0236904&type=printable |
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| author | Merete Ellingjord-Dale Nikos Papadimitriou Michail Katsoulis Chew Yee Niki Dimou Dipender Gill Dagfinn Aune Jue-Sheng Ong Stuart MacGregor Benjamin Elsworth Sarah J Lewis Richard M Martin Elio Riboli Konstantinos K Tsilidis |
| author_facet | Merete Ellingjord-Dale Nikos Papadimitriou Michail Katsoulis Chew Yee Niki Dimou Dipender Gill Dagfinn Aune Jue-Sheng Ong Stuart MacGregor Benjamin Elsworth Sarah J Lewis Richard M Martin Elio Riboli Konstantinos K Tsilidis |
| author_sort | Merete Ellingjord-Dale |
| collection | DOAJ |
| description | <h4>Background</h4>Observational studies have reported either null or weak protective associations for coffee consumption and risk of breast cancer.<h4>Methods</h4>We conducted a two-sample Mendelian randomization (MR) analysis to evaluate the relationship between coffee consumption and breast cancer risk using 33 single-nucleotide polymorphisms (SNPs) associated with coffee consumption from a genome-wide association (GWA) study on 212,119 female UK Biobank participants of White British ancestry. Risk estimates for breast cancer were retrieved from publicly available GWA summary statistics from the Breast Cancer Association Consortium (BCAC) on 122,977 cases (of which 69,501 were estrogen receptor (ER)-positive, 21,468 ER-negative) and 105,974 controls of European ancestry. Random-effects inverse variance weighted (IVW) MR analyses were performed along with several sensitivity analyses to assess the impact of potential MR assumption violations.<h4>Results</h4>One cup per day increase in genetically predicted coffee consumption in women was not associated with risk of total (IVW random-effects; odds ratio (OR): 0.91, 95% confidence intervals (CI): 0.80-1.02, P: 0.12, P for instrument heterogeneity: 7.17e-13), ER-positive (OR = 0.90, 95% CI: 0.79-1.02, P: 0.09) and ER-negative breast cancer (OR: 0.88, 95% CI: 0.75-1.03, P: 0.12). Null associations were also found in the sensitivity analyses using MR-Egger (total breast cancer; OR: 1.00, 95% CI: 0.80-1.25), weighted median (OR: 0.97, 95% CI: 0.89-1.05) and weighted mode (OR: 1.00, CI: 0.93-1.07).<h4>Conclusions</h4>The results of this large MR study do not support an association of genetically predicted coffee consumption on breast cancer risk, but we cannot rule out existence of a weak association. |
| format | Article |
| id | doaj-art-5de0d9dcf17c44c0be69d9610ff2f7a3 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-5de0d9dcf17c44c0be69d9610ff2f7a32025-08-20T02:41:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01161e023690410.1371/journal.pone.0236904Coffee consumption and risk of breast cancer: A Mendelian randomization study.Merete Ellingjord-DaleNikos PapadimitriouMichail KatsoulisChew YeeNiki DimouDipender GillDagfinn AuneJue-Sheng OngStuart MacGregorBenjamin ElsworthSarah J LewisRichard M MartinElio RiboliKonstantinos K Tsilidis<h4>Background</h4>Observational studies have reported either null or weak protective associations for coffee consumption and risk of breast cancer.<h4>Methods</h4>We conducted a two-sample Mendelian randomization (MR) analysis to evaluate the relationship between coffee consumption and breast cancer risk using 33 single-nucleotide polymorphisms (SNPs) associated with coffee consumption from a genome-wide association (GWA) study on 212,119 female UK Biobank participants of White British ancestry. Risk estimates for breast cancer were retrieved from publicly available GWA summary statistics from the Breast Cancer Association Consortium (BCAC) on 122,977 cases (of which 69,501 were estrogen receptor (ER)-positive, 21,468 ER-negative) and 105,974 controls of European ancestry. Random-effects inverse variance weighted (IVW) MR analyses were performed along with several sensitivity analyses to assess the impact of potential MR assumption violations.<h4>Results</h4>One cup per day increase in genetically predicted coffee consumption in women was not associated with risk of total (IVW random-effects; odds ratio (OR): 0.91, 95% confidence intervals (CI): 0.80-1.02, P: 0.12, P for instrument heterogeneity: 7.17e-13), ER-positive (OR = 0.90, 95% CI: 0.79-1.02, P: 0.09) and ER-negative breast cancer (OR: 0.88, 95% CI: 0.75-1.03, P: 0.12). Null associations were also found in the sensitivity analyses using MR-Egger (total breast cancer; OR: 1.00, 95% CI: 0.80-1.25), weighted median (OR: 0.97, 95% CI: 0.89-1.05) and weighted mode (OR: 1.00, CI: 0.93-1.07).<h4>Conclusions</h4>The results of this large MR study do not support an association of genetically predicted coffee consumption on breast cancer risk, but we cannot rule out existence of a weak association.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0236904&type=printable |
| spellingShingle | Merete Ellingjord-Dale Nikos Papadimitriou Michail Katsoulis Chew Yee Niki Dimou Dipender Gill Dagfinn Aune Jue-Sheng Ong Stuart MacGregor Benjamin Elsworth Sarah J Lewis Richard M Martin Elio Riboli Konstantinos K Tsilidis Coffee consumption and risk of breast cancer: A Mendelian randomization study. PLoS ONE |
| title | Coffee consumption and risk of breast cancer: A Mendelian randomization study. |
| title_full | Coffee consumption and risk of breast cancer: A Mendelian randomization study. |
| title_fullStr | Coffee consumption and risk of breast cancer: A Mendelian randomization study. |
| title_full_unstemmed | Coffee consumption and risk of breast cancer: A Mendelian randomization study. |
| title_short | Coffee consumption and risk of breast cancer: A Mendelian randomization study. |
| title_sort | coffee consumption and risk of breast cancer a mendelian randomization study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0236904&type=printable |
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