An Efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitors
N'',N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide, azotic ligands with lone electron pairs, have wide range of applications in catalysis, medicine, corrosion, and analytical chemistry. Keeping this broad range of applications in view, we have developed a new green met...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Kuwait Journal of Science |
| Online Access: | https://journalskuwait.org/kjs/index.php/KJS/article/view/19975 |
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| author | Sarosh Iqbal Shazia Abrar Asma Mukhtar Irfan Ahmad Muhammad Zawar Khan |
| author_facet | Sarosh Iqbal Shazia Abrar Asma Mukhtar Irfan Ahmad Muhammad Zawar Khan |
| author_sort | Sarosh Iqbal |
| collection | DOAJ |
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N'',N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide, azotic ligands with lone electron pairs, have wide range of applications in catalysis, medicine, corrosion, and analytical chemistry. Keeping this broad range of applications in view, we have developed a new green method for rapid synthesis of N'',N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide and its derivatives. By using new protocol, a range of carbonic dihydrazides 1-22 has been synthesized in excellent yields. All synthesized compounds have been characterized by elemental analyses, 1H-NMR, EI-MS and HR-MS. These carbonic dihydrazides have also been synthesized via conventional method. On comparisons of new and conventional methods, it is evident that newly developed solvent-free method is more proficient, high yielding, and simple. All purified and characterized compounds have also been evaluated for their potential to act as in vitro α-chymotrypsin inhibitors. Among tested compounds, ten compounds have shown varying degree of α-chymotrypsin inhibition potential.
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| format | Article |
| id | doaj-art-5dde57ee645b40e8ab505f6394fafa5a |
| institution | OA Journals |
| issn | 2307-4108 2307-4116 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kuwait Journal of Science |
| spelling | doaj-art-5dde57ee645b40e8ab505f6394fafa5a2025-08-20T02:03:36ZengElsevierKuwait Journal of Science2307-41082307-41162023-06-01503A10.48129/kjs.19975An Efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitorsSarosh Iqbal0Shazia Abrar1Asma Mukhtar2Irfan Ahmad3Muhammad Zawar Khan4Dept. of Applied Chemistry, Government College University, Faisalabad-38000, Faisalabad, PakistanDept. of Applied Chemistry, Government College University, Faisalabad-38000, Faisalabad, PakistanDept. of Chemistry and Chemical Engineering, Syed Babar Ali School of Science and Engineering Lahore University of Management Sciences, Lahore-54792, Lahore, PakistanDept. of Chemistry, Government College University, Faisalabad-38000, Faisalabad, PakistanDept. of Chemistry, Government College University, Faisalabad-38000, Faisalabad, Pakistan N'',N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide, azotic ligands with lone electron pairs, have wide range of applications in catalysis, medicine, corrosion, and analytical chemistry. Keeping this broad range of applications in view, we have developed a new green method for rapid synthesis of N'',N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide and its derivatives. By using new protocol, a range of carbonic dihydrazides 1-22 has been synthesized in excellent yields. All synthesized compounds have been characterized by elemental analyses, 1H-NMR, EI-MS and HR-MS. These carbonic dihydrazides have also been synthesized via conventional method. On comparisons of new and conventional methods, it is evident that newly developed solvent-free method is more proficient, high yielding, and simple. All purified and characterized compounds have also been evaluated for their potential to act as in vitro α-chymotrypsin inhibitors. Among tested compounds, ten compounds have shown varying degree of α-chymotrypsin inhibition potential. https://journalskuwait.org/kjs/index.php/KJS/article/view/19975 |
| spellingShingle | Sarosh Iqbal Shazia Abrar Asma Mukhtar Irfan Ahmad Muhammad Zawar Khan An Efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitors Kuwait Journal of Science |
| title | An Efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitors |
| title_full | An Efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitors |
| title_fullStr | An Efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitors |
| title_full_unstemmed | An Efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitors |
| title_short | An Efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitors |
| title_sort | efficient synthesis of n n bis e phenylmethylidene carbonic dihydrazide derivatives and their evaluation as α chymotrypsin nhibitors |
| url | https://journalskuwait.org/kjs/index.php/KJS/article/view/19975 |
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