Gender differences in plasma levels of cardiovascular risk markers and severity indices in Saudi patients with angiographic evidence of coronary artery disease
OBJECTIVE: To evaluate gender difference in non-traditional cardiovascular risk factors among Saudi patients with angiographically defined coronary artery disease (CAD). METHODS: We recruited 144 (male=105, female=39) patients with CAD who underwent coronary angiography. Laboratory analysis of tot...
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Khyber Medical University
2023-06-01
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| Series: | Khyber Medical University Journal |
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| Online Access: | https://www.kmuj.kmu.edu.pk/article/view/22728 |
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| author | Syed Shahid Habib Thamir Al-khlaiwi Abdulrahman Alhowikan Zohair Al Aseri Syed Mohammad Habib Huthayfah Al-khliwi Ahmad Omair |
| author_facet | Syed Shahid Habib Thamir Al-khlaiwi Abdulrahman Alhowikan Zohair Al Aseri Syed Mohammad Habib Huthayfah Al-khliwi Ahmad Omair |
| author_sort | Syed Shahid Habib |
| collection | DOAJ |
| description | OBJECTIVE: To evaluate gender difference in non-traditional cardiovascular risk factors among Saudi patients with angiographically defined coronary artery disease (CAD).
METHODS: We recruited 144 (male=105, female=39) patients with CAD who underwent coronary angiography. Laboratory analysis of total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), lipoprotein(a) [Lp(a)], and high sensitivity C-reactive protein (hs-CRP) were performed along with echocardiographic evaluation.
RESULTS: Systolic blood pressure (SBP) was significantly higher in females (138.65±18.67 vs 129.59±21.03 mmHg; p=0.0363). Although no significant difference was observed in TC (4.30±1.36 vs 4.67±1.07 mmol/L), however significantly higher levels of both HDL and LDL were seen in females (0.86±0.17 vs 0.70±0.23 mmol/L; p=0.0592 and 3.50±0.67 vs 2.72±1.13; p=0.0466 respectively). There were no significant differences in TG, Lp(a) and hs-CRP, however females had comparatively higher Lp(a) (30.43±28.89 vs 24.02±23.42 mg/dl) and hs-CRP (1.14±1.46 vs 0.95±1.25 mg/L). On angiography, greater extent of stenosis was observed in left anterior descending and right coronary arteries among males, while the left circumflex artery was affected more in the female patients without statistical significance (p=0.0797; 0.3890 and 0.5032 respectively). Gensini Score in males & females was 60.46±46.17 and 74.39±39.52 respectively (p=0.3013). Significantly narrower aortic root diameter (ARD) was observed among females (27.30±6.66 vs 29.73±3.40 mm; p=0.0293).
CONCLUSION: Female patients have greater risk of cardiovascular diseases due to higher SBP and LDL levels which could lead to a greater Gensini score when compared to male patients. In addition, narrow ARD among females could also be a contributing factor to CAD. |
| format | Article |
| id | doaj-art-5dddb8cd17ca4115bb1ba34274f4999b |
| institution | OA Journals |
| issn | 2305-2643 2305-2651 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Khyber Medical University |
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| series | Khyber Medical University Journal |
| spelling | doaj-art-5dddb8cd17ca4115bb1ba34274f4999b2025-08-20T01:47:21ZengKhyber Medical UniversityKhyber Medical University Journal2305-26432305-26512023-06-0115271710.35845/kmuj.2023.227281909Gender differences in plasma levels of cardiovascular risk markers and severity indices in Saudi patients with angiographic evidence of coronary artery diseaseSyed Shahid Habib0Thamir Al-khlaiwi1Abdulrahman Alhowikan2Zohair Al Aseri3Syed Mohammad Habib4Huthayfah Al-khliwi5Ahmad Omair6Department of Physiology, College of Medicine and King Khalid University Hospital, Riyadh, Kingdom of Saudi ArabiaDepartment of Physiology, College of Medicine and King Khalid University Hospital, Riyadh, Kingdom of Saudi ArabiaDepartment of Physiology, College of Medicine and King Khalid University Hospital, Riyadh, Kingdom of Saudi ArabiaDepartments of Emergency Medicine and Critical Care, College of Medicine, King Saud University, Riyadh, Saudi ArabiaCollege of Medicine, Sulaiman Al Rajhi University, Al Bukayriah, Saudi ArabiaDepartment of Physiology, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi ArabiaCollege of Science & Health Professions, King Saud bin Abdulaziz University for Health Sciences & King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi ArabiaOBJECTIVE: To evaluate gender difference in non-traditional cardiovascular risk factors among Saudi patients with angiographically defined coronary artery disease (CAD). METHODS: We recruited 144 (male=105, female=39) patients with CAD who underwent coronary angiography. Laboratory analysis of total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), lipoprotein(a) [Lp(a)], and high sensitivity C-reactive protein (hs-CRP) were performed along with echocardiographic evaluation. RESULTS: Systolic blood pressure (SBP) was significantly higher in females (138.65±18.67 vs 129.59±21.03 mmHg; p=0.0363). Although no significant difference was observed in TC (4.30±1.36 vs 4.67±1.07 mmol/L), however significantly higher levels of both HDL and LDL were seen in females (0.86±0.17 vs 0.70±0.23 mmol/L; p=0.0592 and 3.50±0.67 vs 2.72±1.13; p=0.0466 respectively). There were no significant differences in TG, Lp(a) and hs-CRP, however females had comparatively higher Lp(a) (30.43±28.89 vs 24.02±23.42 mg/dl) and hs-CRP (1.14±1.46 vs 0.95±1.25 mg/L). On angiography, greater extent of stenosis was observed in left anterior descending and right coronary arteries among males, while the left circumflex artery was affected more in the female patients without statistical significance (p=0.0797; 0.3890 and 0.5032 respectively). Gensini Score in males & females was 60.46±46.17 and 74.39±39.52 respectively (p=0.3013). Significantly narrower aortic root diameter (ARD) was observed among females (27.30±6.66 vs 29.73±3.40 mm; p=0.0293). CONCLUSION: Female patients have greater risk of cardiovascular diseases due to higher SBP and LDL levels which could lead to a greater Gensini score when compared to male patients. In addition, narrow ARD among females could also be a contributing factor to CAD.https://www.kmuj.kmu.edu.pk/article/view/22728coronary artery diseaseangiographygensini score risk factorssex characteristicscholesteroltriglycerideslipoproteinslipoproteins, hdllipoproteins, ldllipoprotein(a) |
| spellingShingle | Syed Shahid Habib Thamir Al-khlaiwi Abdulrahman Alhowikan Zohair Al Aseri Syed Mohammad Habib Huthayfah Al-khliwi Ahmad Omair Gender differences in plasma levels of cardiovascular risk markers and severity indices in Saudi patients with angiographic evidence of coronary artery disease Khyber Medical University Journal coronary artery disease angiography gensini score risk factors sex characteristics cholesterol triglycerides lipoproteins lipoproteins, hdl lipoproteins, ldl lipoprotein(a) |
| title | Gender differences in plasma levels of cardiovascular risk markers and severity indices in Saudi patients with angiographic evidence of coronary artery disease |
| title_full | Gender differences in plasma levels of cardiovascular risk markers and severity indices in Saudi patients with angiographic evidence of coronary artery disease |
| title_fullStr | Gender differences in plasma levels of cardiovascular risk markers and severity indices in Saudi patients with angiographic evidence of coronary artery disease |
| title_full_unstemmed | Gender differences in plasma levels of cardiovascular risk markers and severity indices in Saudi patients with angiographic evidence of coronary artery disease |
| title_short | Gender differences in plasma levels of cardiovascular risk markers and severity indices in Saudi patients with angiographic evidence of coronary artery disease |
| title_sort | gender differences in plasma levels of cardiovascular risk markers and severity indices in saudi patients with angiographic evidence of coronary artery disease |
| topic | coronary artery disease angiography gensini score risk factors sex characteristics cholesterol triglycerides lipoproteins lipoproteins, hdl lipoproteins, ldl lipoprotein(a) |
| url | https://www.kmuj.kmu.edu.pk/article/view/22728 |
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