Long-Term Recording of LTP in Cultured Hippocampal Slices
Long-term potentiation (LTP) was elicited by high frequency stimulation in hippocampal slices cultured on multi-electrode arrays. LTP lasting more than 1 h was recorded in 75% of slices, and a significant number of slices exhibited a non-decaying LTP that lasted more than 48 h. LTP induction was com...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2002-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2002.249 |
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| Summary: | Long-term potentiation (LTP) was elicited
by high frequency stimulation in hippocampal
slices cultured on multi-electrode arrays. LTP
lasting more than 1 h was recorded in 75% of
slices, and a significant number of slices
exhibited a non-decaying LTP that lasted more
than 48 h. LTP induction was completely and
reversibly blocked by an antagonist of the
NMDA receptor, APV. Our results suggest the
possibility of using chronic recording in
hippocampal slices cultured on multi-electrode
arrays to study the mechanisms underlying
LTP maintenance and stabilization. |
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| ISSN: | 2090-5904 1687-5443 |