The levels of miR-155 in epilepsy patients: a meta-analysis
BackgroundNeuroinflammation plays an important role in the development and progression of epilepsy. It can be both a result and a potential cause of those seizures. MiR-155 plays a crucial role in inflammatory responses, and its expression is upregulated under various neuroinflammatory conditions. T...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-08-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1630581/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849770486187163648 |
|---|---|
| author | Yi Wang Cong Chen Chengyu Ya Jiangwei Chen Bingfang Lu Jinwen Liu Qiong Wu Limei Diao Huihua Liu |
| author_facet | Yi Wang Cong Chen Chengyu Ya Jiangwei Chen Bingfang Lu Jinwen Liu Qiong Wu Limei Diao Huihua Liu |
| author_sort | Yi Wang |
| collection | DOAJ |
| description | BackgroundNeuroinflammation plays an important role in the development and progression of epilepsy. It can be both a result and a potential cause of those seizures. MiR-155 plays a crucial role in inflammatory responses, and its expression is upregulated under various neuroinflammatory conditions. This study aims to compare the expression levels of miR-155 in the brain tissue or serum of epilepsy patients and healthy controls, assessing the correlation between miR-155 levels and epilepsy.ObjectiveThe meta-analysis evaluates to assess and compare the levels of miR-155 in the brain tissue and serum of epilepsy patients and healthy controls.MethodsThe databases PubMed, Embase, Cochrane Library, CNKI, VIP, and WanFang DATA were searched from inception until Dec 30, 2024 by two researchers. The relative expression level of miR-155 in the tissues or serum was the primary outcome of the search. After extracting data independently, the two researchers used the Cochrane Collaboration’s tool for assessing risk of bias. All data were analyzed using Review Manager (V.5.4.1) statistical software.ResultsThis meta-analysis (nine studies, 394 patients) reveals elevated miR-155 in epilepsy patients vs. controls (SMD = 1.62, p = 0.001), especially in brain tissue. Subgroups confirm consistency across ages/regions. Subgroup analysis revealed no significant differences by country (p = 0.31), age category (p = 0.63) and sample source (p = 0.15), indicating robust consistency of the primary findings. MiR-155 may serve as a neuroinflammatory biomarker in epilepsy.ConclusionCompared to healthy controls, the relative expression level of miR-155 in the brain tissue or serum of epilepsy patients increased.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42024558255. |
| format | Article |
| id | doaj-art-5ddc00af5e954dadb1d1fd3af3d38f2b |
| institution | DOAJ |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-5ddc00af5e954dadb1d1fd3af3d38f2b2025-08-20T03:02:59ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-08-011610.3389/fneur.2025.16305811630581The levels of miR-155 in epilepsy patients: a meta-analysisYi Wang0Cong Chen1Chengyu Ya2Jiangwei Chen3Bingfang Lu4Jinwen Liu5Qiong Wu6Limei Diao7Huihua Liu8Graduate School of First Clinical Medicine College, Guangxi University of Chinese Medicine, Nanning, Guangxi, ChinaDepartment of Neurology, Putian Hanjiang Hospital, Putian, Fujian, ChinaGraduate School of First Clinical Medicine College, Guangxi University of Chinese Medicine, Nanning, Guangxi, ChinaGraduate School of First Clinical Medicine College, Guangxi University of Chinese Medicine, Nanning, Guangxi, ChinaGraduate School of First Clinical Medicine College, Guangxi University of Chinese Medicine, Nanning, Guangxi, ChinaGraduate School of First Clinical Medicine College, Guangxi University of Chinese Medicine, Nanning, Guangxi, ChinaDepartment of Pediatric Rehabilitation, Xinyang Central Hospital, Xinyang, Henan, ChinaDepartment of Neurology, Guangxi Zhuang Autonomous Region Brain Hospital, Liuzhou, Guangxi, ChinaDepartment of Neurology, Guangxi Zhuang Autonomous Region Brain Hospital, Liuzhou, Guangxi, ChinaBackgroundNeuroinflammation plays an important role in the development and progression of epilepsy. It can be both a result and a potential cause of those seizures. MiR-155 plays a crucial role in inflammatory responses, and its expression is upregulated under various neuroinflammatory conditions. This study aims to compare the expression levels of miR-155 in the brain tissue or serum of epilepsy patients and healthy controls, assessing the correlation between miR-155 levels and epilepsy.ObjectiveThe meta-analysis evaluates to assess and compare the levels of miR-155 in the brain tissue and serum of epilepsy patients and healthy controls.MethodsThe databases PubMed, Embase, Cochrane Library, CNKI, VIP, and WanFang DATA were searched from inception until Dec 30, 2024 by two researchers. The relative expression level of miR-155 in the tissues or serum was the primary outcome of the search. After extracting data independently, the two researchers used the Cochrane Collaboration’s tool for assessing risk of bias. All data were analyzed using Review Manager (V.5.4.1) statistical software.ResultsThis meta-analysis (nine studies, 394 patients) reveals elevated miR-155 in epilepsy patients vs. controls (SMD = 1.62, p = 0.001), especially in brain tissue. Subgroups confirm consistency across ages/regions. Subgroup analysis revealed no significant differences by country (p = 0.31), age category (p = 0.63) and sample source (p = 0.15), indicating robust consistency of the primary findings. MiR-155 may serve as a neuroinflammatory biomarker in epilepsy.ConclusionCompared to healthy controls, the relative expression level of miR-155 in the brain tissue or serum of epilepsy patients increased.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42024558255.https://www.frontiersin.org/articles/10.3389/fneur.2025.1630581/fullepilepsymiR-155neuroinflammationbiomarkermeta-analysis |
| spellingShingle | Yi Wang Cong Chen Chengyu Ya Jiangwei Chen Bingfang Lu Jinwen Liu Qiong Wu Limei Diao Huihua Liu The levels of miR-155 in epilepsy patients: a meta-analysis Frontiers in Neurology epilepsy miR-155 neuroinflammation biomarker meta-analysis |
| title | The levels of miR-155 in epilepsy patients: a meta-analysis |
| title_full | The levels of miR-155 in epilepsy patients: a meta-analysis |
| title_fullStr | The levels of miR-155 in epilepsy patients: a meta-analysis |
| title_full_unstemmed | The levels of miR-155 in epilepsy patients: a meta-analysis |
| title_short | The levels of miR-155 in epilepsy patients: a meta-analysis |
| title_sort | levels of mir 155 in epilepsy patients a meta analysis |
| topic | epilepsy miR-155 neuroinflammation biomarker meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1630581/full |
| work_keys_str_mv | AT yiwang thelevelsofmir155inepilepsypatientsametaanalysis AT congchen thelevelsofmir155inepilepsypatientsametaanalysis AT chengyuya thelevelsofmir155inepilepsypatientsametaanalysis AT jiangweichen thelevelsofmir155inepilepsypatientsametaanalysis AT bingfanglu thelevelsofmir155inepilepsypatientsametaanalysis AT jinwenliu thelevelsofmir155inepilepsypatientsametaanalysis AT qiongwu thelevelsofmir155inepilepsypatientsametaanalysis AT limeidiao thelevelsofmir155inepilepsypatientsametaanalysis AT huihualiu thelevelsofmir155inepilepsypatientsametaanalysis AT yiwang levelsofmir155inepilepsypatientsametaanalysis AT congchen levelsofmir155inepilepsypatientsametaanalysis AT chengyuya levelsofmir155inepilepsypatientsametaanalysis AT jiangweichen levelsofmir155inepilepsypatientsametaanalysis AT bingfanglu levelsofmir155inepilepsypatientsametaanalysis AT jinwenliu levelsofmir155inepilepsypatientsametaanalysis AT qiongwu levelsofmir155inepilepsypatientsametaanalysis AT limeidiao levelsofmir155inepilepsypatientsametaanalysis AT huihualiu levelsofmir155inepilepsypatientsametaanalysis |