A Rare Collision Tumor Composed of Follicular Lymphoma and Adenocarcinoma in the Ampulla of Vater: A Case Report
The duodenum is infrequently affected by malignant lymphoma, and follicular lymphomas of the duodenum are rare histological subtypes. There are no reported cases of collision of follicular lymphoma and other tumors in the ampulla of Vater. A 57-year-old Japanese man presented with jaundice, and abdo...
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Wiley
2014-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2014/530727 |
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| author | Shioto Suzuki Fumihiko Tanioka Keisuke Inaba Shingo Takatori Hideto Ochiai Shohachi Suzuki |
| author_facet | Shioto Suzuki Fumihiko Tanioka Keisuke Inaba Shingo Takatori Hideto Ochiai Shohachi Suzuki |
| author_sort | Shioto Suzuki |
| collection | DOAJ |
| description | The duodenum is infrequently affected by malignant lymphoma, and follicular lymphomas of the duodenum are rare histological subtypes. There are no reported cases of collision of follicular lymphoma and other tumors in the ampulla of Vater. A 57-year-old Japanese man presented with jaundice, and abdominal computed tomography revealed a tumor of the ampulla of Vater invading the pancreatic head with biliary dilatation and a thickened duodenal wall. The patient underwent subtotal stomach-preserving pancreaticoduodenectomy. Histopathology of the resected specimen revealed lymphoid follicular formations with small-to-medium-sized centrocyte-like cells and some centroblast-like cells. The atypical lymphoid cells were immunohistochemically positive for CD10, CD20, and CD79a but negative for CD5 and cyclin D1. BCL2 protein was highly expressed in the follicle centers. The diagnosis was duodenal follicular lymphoma, Grade 1. The follicular lymphoma, 40 mm in diameter, involved duodenal submucosa and regional lymph nodes without distant metastasis. This duodenal follicular lymphoma was partially overlapped by adenocarcinoma of the ampulla of Vater, measuring 25×20 mm, which involved the lower common bile duct, pancreas, and duodenum. We report the first case of a surgically treated collision tumor composed of a rare mass-forming follicular lymphoma and adenocarcinoma of the ampulla of Vater. |
| format | Article |
| id | doaj-art-5dd032c8e62e4cab98393e15af18c4d2 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-5dd032c8e62e4cab98393e15af18c4d22025-02-03T01:04:57ZengWileyCase Reports in Pathology2090-67812090-679X2014-01-01201410.1155/2014/530727530727A Rare Collision Tumor Composed of Follicular Lymphoma and Adenocarcinoma in the Ampulla of Vater: A Case ReportShioto Suzuki0Fumihiko Tanioka1Keisuke Inaba2Shingo Takatori3Hideto Ochiai4Shohachi Suzuki5Division of Pathology, Iwata City Hospital, 512-3 Ookubo, Iwata, Shizuoka 438-8550, JapanDivision of Pathology, Iwata City Hospital, 512-3 Ookubo, Iwata, Shizuoka 438-8550, JapanDivision of Gastroenterological Surgery, Iwata City Hospital, 512-3 Ookubo, Iwata, Shizuoka 438-8550, JapanDivision of Gastroenterology, Iwata City Hospital, 512-3 Ookubo, Iwata, Shizuoka 438-8550, JapanDivision of Gastroenterological Surgery, Iwata City Hospital, 512-3 Ookubo, Iwata, Shizuoka 438-8550, JapanDivision of Gastroenterological Surgery, Iwata City Hospital, 512-3 Ookubo, Iwata, Shizuoka 438-8550, JapanThe duodenum is infrequently affected by malignant lymphoma, and follicular lymphomas of the duodenum are rare histological subtypes. There are no reported cases of collision of follicular lymphoma and other tumors in the ampulla of Vater. A 57-year-old Japanese man presented with jaundice, and abdominal computed tomography revealed a tumor of the ampulla of Vater invading the pancreatic head with biliary dilatation and a thickened duodenal wall. The patient underwent subtotal stomach-preserving pancreaticoduodenectomy. Histopathology of the resected specimen revealed lymphoid follicular formations with small-to-medium-sized centrocyte-like cells and some centroblast-like cells. The atypical lymphoid cells were immunohistochemically positive for CD10, CD20, and CD79a but negative for CD5 and cyclin D1. BCL2 protein was highly expressed in the follicle centers. The diagnosis was duodenal follicular lymphoma, Grade 1. The follicular lymphoma, 40 mm in diameter, involved duodenal submucosa and regional lymph nodes without distant metastasis. This duodenal follicular lymphoma was partially overlapped by adenocarcinoma of the ampulla of Vater, measuring 25×20 mm, which involved the lower common bile duct, pancreas, and duodenum. We report the first case of a surgically treated collision tumor composed of a rare mass-forming follicular lymphoma and adenocarcinoma of the ampulla of Vater.http://dx.doi.org/10.1155/2014/530727 |
| spellingShingle | Shioto Suzuki Fumihiko Tanioka Keisuke Inaba Shingo Takatori Hideto Ochiai Shohachi Suzuki A Rare Collision Tumor Composed of Follicular Lymphoma and Adenocarcinoma in the Ampulla of Vater: A Case Report Case Reports in Pathology |
| title | A Rare Collision Tumor Composed of Follicular Lymphoma and Adenocarcinoma in the Ampulla of Vater: A Case Report |
| title_full | A Rare Collision Tumor Composed of Follicular Lymphoma and Adenocarcinoma in the Ampulla of Vater: A Case Report |
| title_fullStr | A Rare Collision Tumor Composed of Follicular Lymphoma and Adenocarcinoma in the Ampulla of Vater: A Case Report |
| title_full_unstemmed | A Rare Collision Tumor Composed of Follicular Lymphoma and Adenocarcinoma in the Ampulla of Vater: A Case Report |
| title_short | A Rare Collision Tumor Composed of Follicular Lymphoma and Adenocarcinoma in the Ampulla of Vater: A Case Report |
| title_sort | rare collision tumor composed of follicular lymphoma and adenocarcinoma in the ampulla of vater a case report |
| url | http://dx.doi.org/10.1155/2014/530727 |
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