Post-fertilization transcription initiation in an ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2

Post-fertilization transcription initiation in an ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2

The imprinted gene ZDBF2 is regulated through a unique mechanism involving a transient paternal transcript in early embryos, rather than persistent gametic DNA methylation. In humans and mice, this transcript—CMKLR2-AS (also known as GPR1-AS) or the long isoform of Zdbf2 (Liz/Zdbf2linc/Platr12)—aris...

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Bibliographic Details
Main Authors: Hisato Kobayashi, Tatsushi Igaki, Soichiro Kumamoto, Keisuke Tanaka, Tomoya Takashima, So I Nagaoka, Shunsuke Suzuki, Masaaki Hayashi, Marilyn B Renfree, Manabu Kawahara, Shun Saito, Toshihiro Kobayashi, Hiroshi Nagashima, Hitomi Matsunari, Kazuaki Nakano, Ayuko Uchikura, Hiroshi Kiyonari, Mari Kaneko, Hiroo Imai, Kazuhiko Nakabayashi, Matthew Lorincz, Kazuki Kurimoto
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-06-01
Series:eLife
Subjects:
genomic imprinting
LTR retrotransposon
mammalian evolution
placenta
RNA-seq
Online Access:https://elifesciences.org/articles/94502
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