Use of Aldosterone Antagonist to Treat Diarrhea and Hypokalemia of Ogilvie’s Syndrome
Ogilvie’s syndrome (OS) is a functional obstruction of the bowel due to an autonomic imbalance. It often presents with diarrhea and is associated with hypokalemia. We present a case of a 70-year-old male who developed severe abdominal distension, watery diarrhea, and persistent hypokalemia status af...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/1207240 |
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| author | Pradhum Ram Abhinav Goyal Marvin Lu Joshua Sloan William McElhaugh |
| author_facet | Pradhum Ram Abhinav Goyal Marvin Lu Joshua Sloan William McElhaugh |
| author_sort | Pradhum Ram |
| collection | DOAJ |
| description | Ogilvie’s syndrome (OS) is a functional obstruction of the bowel due to an autonomic imbalance. It often presents with diarrhea and is associated with hypokalemia. We present a case of a 70-year-old male who developed severe abdominal distension, watery diarrhea, and persistent hypokalemia status after left hip arthroplasty after suffering from a femoral neck fracture due to a fall and was diagnosed with OS. The persistent hypokalemia was slow to improve despite aggressive repletion because of the high potassium losses in the stool. This is most likely mediated through the increased expression of BK channels in the colonic mucosa. Aldosterone is theorized to have a role in the regulation of BK channels. Spironolactone was subsequently given and resulted in marked improvement of the diarrhea and hypokalemia. Thus, this case suggests a novel therapeutic approach for the treatment of Ogilvie’s syndrome-associated diarrhea and hypokalemia. |
| format | Article |
| id | doaj-art-5dc4d876d33d4c8b8df9d253c9228daf |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-5dc4d876d33d4c8b8df9d253c9228daf2025-08-20T03:34:44ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362016-01-01201610.1155/2016/12072401207240Use of Aldosterone Antagonist to Treat Diarrhea and Hypokalemia of Ogilvie’s SyndromePradhum Ram0Abhinav Goyal1Marvin Lu2Joshua Sloan3William McElhaugh4Einstein Medical Center, Philadelphia, PA, USAEinstein Medical Center, Philadelphia, PA, USAEinstein Medical Center, Philadelphia, PA, USAEinstein Medical Center, Philadelphia, PA, USAEinstein Medical Center, Philadelphia, PA, USAOgilvie’s syndrome (OS) is a functional obstruction of the bowel due to an autonomic imbalance. It often presents with diarrhea and is associated with hypokalemia. We present a case of a 70-year-old male who developed severe abdominal distension, watery diarrhea, and persistent hypokalemia status after left hip arthroplasty after suffering from a femoral neck fracture due to a fall and was diagnosed with OS. The persistent hypokalemia was slow to improve despite aggressive repletion because of the high potassium losses in the stool. This is most likely mediated through the increased expression of BK channels in the colonic mucosa. Aldosterone is theorized to have a role in the regulation of BK channels. Spironolactone was subsequently given and resulted in marked improvement of the diarrhea and hypokalemia. Thus, this case suggests a novel therapeutic approach for the treatment of Ogilvie’s syndrome-associated diarrhea and hypokalemia.http://dx.doi.org/10.1155/2016/1207240 |
| spellingShingle | Pradhum Ram Abhinav Goyal Marvin Lu Joshua Sloan William McElhaugh Use of Aldosterone Antagonist to Treat Diarrhea and Hypokalemia of Ogilvie’s Syndrome Case Reports in Gastrointestinal Medicine |
| title | Use of Aldosterone Antagonist to Treat Diarrhea and Hypokalemia of Ogilvie’s Syndrome |
| title_full | Use of Aldosterone Antagonist to Treat Diarrhea and Hypokalemia of Ogilvie’s Syndrome |
| title_fullStr | Use of Aldosterone Antagonist to Treat Diarrhea and Hypokalemia of Ogilvie’s Syndrome |
| title_full_unstemmed | Use of Aldosterone Antagonist to Treat Diarrhea and Hypokalemia of Ogilvie’s Syndrome |
| title_short | Use of Aldosterone Antagonist to Treat Diarrhea and Hypokalemia of Ogilvie’s Syndrome |
| title_sort | use of aldosterone antagonist to treat diarrhea and hypokalemia of ogilvie s syndrome |
| url | http://dx.doi.org/10.1155/2016/1207240 |
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