Cardiovascular risk factors in relation to hair polycyclic aromatic hydrocarbons in the NESCAV study
Previous studies have found associations between exposure to polycyclic aromatic hydrocarbons (PAHs) and cardiovascular risk factors. However, the internal dose of PAH exposure was often examined by quantifying monohydroxylated metabolites of PAHs (OH-PAHs) in urine, which can only reflect recent ex...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412024007566 |
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| author | Feng-Jiao Peng Chia-An Lin Rin Wada Barbara Bodinier Alba Iglesias-González Paul Palazzi Sylvie Streel Michèle Guillaume Marc Chadeau-Hyam Brice M.R. Appenzeller |
| author_facet | Feng-Jiao Peng Chia-An Lin Rin Wada Barbara Bodinier Alba Iglesias-González Paul Palazzi Sylvie Streel Michèle Guillaume Marc Chadeau-Hyam Brice M.R. Appenzeller |
| author_sort | Feng-Jiao Peng |
| collection | DOAJ |
| description | Previous studies have found associations between exposure to polycyclic aromatic hydrocarbons (PAHs) and cardiovascular risk factors. However, the internal dose of PAH exposure was often examined by quantifying monohydroxylated metabolites of PAHs (OH-PAHs) in urine, which can only reflect recent exposure. On the other hand, hair covers wider temporal windows than urine and has been demonstrated to be a suitable matrix for PAH exposure assessment. Using hair analysis, here we investigated the associations between PAH exposure and obesity, diabetes, hypertension, dyslipidemia, and metabolic syndrome (MetS) and its components in a cross-sectional study of adults aged 18–69 years and enrolled in the Nutrition, Environment and Cardiovascular Health (NESCAV) survey conducted in 2007–2009 in Luxembourg. In addition, we also examined hair cotinine and nicotine because they are well-established biomarkers of tobacco smoke exposure. Associations were explored separately for men (n = 265) and women (n = 347) by logistic regression with adjustment for potential confounders. We found positive associations of OH-PAHs with diabetes in both men and women, positive and inverse associations with obesity and positive associations with hypertension/elevated blood pressure and dyslipidemia/elevated triglycerides (TG) in men, and inverse associations with hypertension but positive associations with MetS, elevated waist circumference and reduced high-density lipoprotein cholesterol (HDL-C) in women. These results may suggest that men and women differ in cardiometabolic responses to environmental PAH exposure. As regards hair cotinine and nicotine, they were associated with diabetes/elevated fasting plasma glucose, elevated blood pressure, and dyslipidemia/elevated TG/reduced HDL-C in men and women. Our results suggest that exposure to PAHs and tobacco smoke may be associated with cardiometabolic health risk. Future prospective studies are warranted to corroborate these findings. |
| format | Article |
| id | doaj-art-5dc379de29834b51be220625f4fe52d4 |
| institution | OA Journals |
| issn | 0160-4120 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj-art-5dc379de29834b51be220625f4fe52d42025-08-20T01:58:08ZengElsevierEnvironment International0160-41202024-12-0119410917010.1016/j.envint.2024.109170Cardiovascular risk factors in relation to hair polycyclic aromatic hydrocarbons in the NESCAV studyFeng-Jiao Peng0Chia-An Lin1Rin Wada2Barbara Bodinier3Alba Iglesias-González4Paul Palazzi5Sylvie Streel6Michèle Guillaume7Marc Chadeau-Hyam8Brice M.R. Appenzeller9Human Biomonitoring Research Unit, Department of Precision Health, Luxembourg Institute of Health, 1 A-B rue Thomas Edison 1445, Strassen, LuxembourgMRC/PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United KingdomMRC/PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United KingdomMRC/PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United KingdomHuman Biomonitoring Research Unit, Department of Precision Health, Luxembourg Institute of Health, 1 A-B rue Thomas Edison 1445, Strassen, LuxembourgHuman Biomonitoring Research Unit, Department of Precision Health, Luxembourg Institute of Health, 1 A-B rue Thomas Edison 1445, Strassen, LuxembourgPublic Health Sciences Department, University of Liege, Liège, BelgiumPublic Health Sciences Department, University of Liege, Liège, BelgiumMRC/PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United KingdomHuman Biomonitoring Research Unit, Department of Precision Health, Luxembourg Institute of Health, 1 A-B rue Thomas Edison 1445, Strassen, Luxembourg; Corresponding author.Previous studies have found associations between exposure to polycyclic aromatic hydrocarbons (PAHs) and cardiovascular risk factors. However, the internal dose of PAH exposure was often examined by quantifying monohydroxylated metabolites of PAHs (OH-PAHs) in urine, which can only reflect recent exposure. On the other hand, hair covers wider temporal windows than urine and has been demonstrated to be a suitable matrix for PAH exposure assessment. Using hair analysis, here we investigated the associations between PAH exposure and obesity, diabetes, hypertension, dyslipidemia, and metabolic syndrome (MetS) and its components in a cross-sectional study of adults aged 18–69 years and enrolled in the Nutrition, Environment and Cardiovascular Health (NESCAV) survey conducted in 2007–2009 in Luxembourg. In addition, we also examined hair cotinine and nicotine because they are well-established biomarkers of tobacco smoke exposure. Associations were explored separately for men (n = 265) and women (n = 347) by logistic regression with adjustment for potential confounders. We found positive associations of OH-PAHs with diabetes in both men and women, positive and inverse associations with obesity and positive associations with hypertension/elevated blood pressure and dyslipidemia/elevated triglycerides (TG) in men, and inverse associations with hypertension but positive associations with MetS, elevated waist circumference and reduced high-density lipoprotein cholesterol (HDL-C) in women. These results may suggest that men and women differ in cardiometabolic responses to environmental PAH exposure. As regards hair cotinine and nicotine, they were associated with diabetes/elevated fasting plasma glucose, elevated blood pressure, and dyslipidemia/elevated TG/reduced HDL-C in men and women. Our results suggest that exposure to PAHs and tobacco smoke may be associated with cardiometabolic health risk. Future prospective studies are warranted to corroborate these findings.http://www.sciencedirect.com/science/article/pii/S0160412024007566Hair analysisNicotineNaphthalenePhenanthreneHypertensionDyslipidemia |
| spellingShingle | Feng-Jiao Peng Chia-An Lin Rin Wada Barbara Bodinier Alba Iglesias-González Paul Palazzi Sylvie Streel Michèle Guillaume Marc Chadeau-Hyam Brice M.R. Appenzeller Cardiovascular risk factors in relation to hair polycyclic aromatic hydrocarbons in the NESCAV study Environment International Hair analysis Nicotine Naphthalene Phenanthrene Hypertension Dyslipidemia |
| title | Cardiovascular risk factors in relation to hair polycyclic aromatic hydrocarbons in the NESCAV study |
| title_full | Cardiovascular risk factors in relation to hair polycyclic aromatic hydrocarbons in the NESCAV study |
| title_fullStr | Cardiovascular risk factors in relation to hair polycyclic aromatic hydrocarbons in the NESCAV study |
| title_full_unstemmed | Cardiovascular risk factors in relation to hair polycyclic aromatic hydrocarbons in the NESCAV study |
| title_short | Cardiovascular risk factors in relation to hair polycyclic aromatic hydrocarbons in the NESCAV study |
| title_sort | cardiovascular risk factors in relation to hair polycyclic aromatic hydrocarbons in the nescav study |
| topic | Hair analysis Nicotine Naphthalene Phenanthrene Hypertension Dyslipidemia |
| url | http://www.sciencedirect.com/science/article/pii/S0160412024007566 |
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