Pituitary Gland and Neurological Involvement in a Case of Hemophagocytic Syndrome Revealing an Intravascular Large B-Cell Lymphoma

Intravascular large B-cell lymphoma is a rare entity characterized by the proliferation of neoplastic lymphocytes in the lumen of small blood vessels and high mortality. Diagnosis of intravascular lymphoma is often delayed or established postmortem. Here, we report the case of a 48-year-old woman pr...

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Main Authors: Sylvain Raoul Simeni Njonnou, Bruno Couturier, Yannick Gombeir, Sylvain Verbanck, France Devuyst, Georges El Hachem, Ivan Theate, Anne-Laure Trepant, Virginie De Wilde, Frédéric-Alain Vandergheynst
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Case Reports in Hematology
Online Access:http://dx.doi.org/10.1155/2019/9625075
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author Sylvain Raoul Simeni Njonnou
Bruno Couturier
Yannick Gombeir
Sylvain Verbanck
France Devuyst
Georges El Hachem
Ivan Theate
Anne-Laure Trepant
Virginie De Wilde
Frédéric-Alain Vandergheynst
author_facet Sylvain Raoul Simeni Njonnou
Bruno Couturier
Yannick Gombeir
Sylvain Verbanck
France Devuyst
Georges El Hachem
Ivan Theate
Anne-Laure Trepant
Virginie De Wilde
Frédéric-Alain Vandergheynst
author_sort Sylvain Raoul Simeni Njonnou
collection DOAJ
description Intravascular large B-cell lymphoma is a rare entity characterized by the proliferation of neoplastic lymphocytes in the lumen of small blood vessels and high mortality. Diagnosis of intravascular lymphoma is often delayed or established postmortem. Here, we report the case of a 48-year-old woman presenting hemophagocytic syndrome, with pituitary gland and neurological involvement. Diagnosis of intravascular large B-cell lymphoma was made on perisplenic vessels, while liver and bone marrow biopsy was noncontributive. This case demonstrates the importance of thorough histopathologic investigations in the setting of high suspicion.
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spelling doaj-art-5dbf1cda94634e1fbc9a1819eb2722eb2025-08-20T02:06:03ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/96250759625075Pituitary Gland and Neurological Involvement in a Case of Hemophagocytic Syndrome Revealing an Intravascular Large B-Cell LymphomaSylvain Raoul Simeni Njonnou0Bruno Couturier1Yannick Gombeir2Sylvain Verbanck3France Devuyst4Georges El Hachem5Ivan Theate6Anne-Laure Trepant7Virginie De Wilde8Frédéric-Alain Vandergheynst9Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaoundé, CameroonDepartment of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Endocrinology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, BelgiumInstitute of Pathology and Genetics, Gosselies, Charleroi, BelgiumDepartment of Pathology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Hematology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, BelgiumIntravascular large B-cell lymphoma is a rare entity characterized by the proliferation of neoplastic lymphocytes in the lumen of small blood vessels and high mortality. Diagnosis of intravascular lymphoma is often delayed or established postmortem. Here, we report the case of a 48-year-old woman presenting hemophagocytic syndrome, with pituitary gland and neurological involvement. Diagnosis of intravascular large B-cell lymphoma was made on perisplenic vessels, while liver and bone marrow biopsy was noncontributive. This case demonstrates the importance of thorough histopathologic investigations in the setting of high suspicion.http://dx.doi.org/10.1155/2019/9625075
spellingShingle Sylvain Raoul Simeni Njonnou
Bruno Couturier
Yannick Gombeir
Sylvain Verbanck
France Devuyst
Georges El Hachem
Ivan Theate
Anne-Laure Trepant
Virginie De Wilde
Frédéric-Alain Vandergheynst
Pituitary Gland and Neurological Involvement in a Case of Hemophagocytic Syndrome Revealing an Intravascular Large B-Cell Lymphoma
Case Reports in Hematology
title Pituitary Gland and Neurological Involvement in a Case of Hemophagocytic Syndrome Revealing an Intravascular Large B-Cell Lymphoma
title_full Pituitary Gland and Neurological Involvement in a Case of Hemophagocytic Syndrome Revealing an Intravascular Large B-Cell Lymphoma
title_fullStr Pituitary Gland and Neurological Involvement in a Case of Hemophagocytic Syndrome Revealing an Intravascular Large B-Cell Lymphoma
title_full_unstemmed Pituitary Gland and Neurological Involvement in a Case of Hemophagocytic Syndrome Revealing an Intravascular Large B-Cell Lymphoma
title_short Pituitary Gland and Neurological Involvement in a Case of Hemophagocytic Syndrome Revealing an Intravascular Large B-Cell Lymphoma
title_sort pituitary gland and neurological involvement in a case of hemophagocytic syndrome revealing an intravascular large b cell lymphoma
url http://dx.doi.org/10.1155/2019/9625075
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