Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk.
<h4>Background</h4>Interleukin-1 beta (IL-1β), a pro-inflammatory cytokine, is emerging as a key mediator of carcinogenesis that characterizes host-environment interactions. Epidemiological studies investigating the association between two polymorphisms of IL-1B (-511C/T and +3954C/T) an...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0063654 |
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| author | Jiali Xu Zhiqiang Yin Songyu Cao Wen Gao Lingxiang Liu Yongmei Yin Ping Liu Yongqian Shu |
| author_facet | Jiali Xu Zhiqiang Yin Songyu Cao Wen Gao Lingxiang Liu Yongmei Yin Ping Liu Yongqian Shu |
| author_sort | Jiali Xu |
| collection | DOAJ |
| description | <h4>Background</h4>Interleukin-1 beta (IL-1β), a pro-inflammatory cytokine, is emerging as a key mediator of carcinogenesis that characterizes host-environment interactions. Epidemiological studies investigating the association between two polymorphisms of IL-1B (-511C/T and +3954C/T) and cancer susceptibility have shown conflicting results. The aim of this study is to derive a more precise estimation of the relationship.<h4>Methods</h4>Related studies were identified through a systematic literature search of PubMed and Web of Science from their inception to September 15, 2012. Summary odds ratios (ORs) and 95% confidence intervals (CIs) for the IL-1B -511C/T and +3954C/T polymorphisms and cancer risk were calculated. Heterogeneity among studies and publication bias were also tested.<h4>Results</h4>The meta-analysis included 91 case-control studies in 85 publications, 81 studies for the -511C/T (19547 cases and 23935 controls) and 26 studies for the +3954C/T polymorphisms (8083 cases and 9183). The pooled results indicated that IL-1B +3954C/T (dominant model: OR = 1.15, 95% CI: 1.01-1.30) was significantly associated with increased overall cancer risk, especially among hospital-based case-control studies (dominant model: OR = 1.30, 95% CI: 1.02-1.66). As for -511C/T, we observed an inverse relationship in cervical cancer (dominant model: OR = 1.74, 95% CI: 1.35-2.23) and hepatocellular carcinoma (dominant model: OR = 0.68, 95% CI: 0.47-0.99). Moreover, -511C/T was associated with risk of specific subtypes of gastric carcinoma.<h4>Conclusion</h4>This meta-analysis suggested that both the IL-1B -511C/T and +3954C/T polymorphisms might modulate cancer susceptibility. Further well-designed studies based on larger sample sizes should be performed to confirm the findings. |
| format | Article |
| id | doaj-art-5db783118fc34253b0dcd55abf1aab9e |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-5db783118fc34253b0dcd55abf1aab9e2025-08-20T03:49:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0185e6365410.1371/journal.pone.0063654Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk.Jiali XuZhiqiang YinSongyu CaoWen GaoLingxiang LiuYongmei YinPing LiuYongqian Shu<h4>Background</h4>Interleukin-1 beta (IL-1β), a pro-inflammatory cytokine, is emerging as a key mediator of carcinogenesis that characterizes host-environment interactions. Epidemiological studies investigating the association between two polymorphisms of IL-1B (-511C/T and +3954C/T) and cancer susceptibility have shown conflicting results. The aim of this study is to derive a more precise estimation of the relationship.<h4>Methods</h4>Related studies were identified through a systematic literature search of PubMed and Web of Science from their inception to September 15, 2012. Summary odds ratios (ORs) and 95% confidence intervals (CIs) for the IL-1B -511C/T and +3954C/T polymorphisms and cancer risk were calculated. Heterogeneity among studies and publication bias were also tested.<h4>Results</h4>The meta-analysis included 91 case-control studies in 85 publications, 81 studies for the -511C/T (19547 cases and 23935 controls) and 26 studies for the +3954C/T polymorphisms (8083 cases and 9183). The pooled results indicated that IL-1B +3954C/T (dominant model: OR = 1.15, 95% CI: 1.01-1.30) was significantly associated with increased overall cancer risk, especially among hospital-based case-control studies (dominant model: OR = 1.30, 95% CI: 1.02-1.66). As for -511C/T, we observed an inverse relationship in cervical cancer (dominant model: OR = 1.74, 95% CI: 1.35-2.23) and hepatocellular carcinoma (dominant model: OR = 0.68, 95% CI: 0.47-0.99). Moreover, -511C/T was associated with risk of specific subtypes of gastric carcinoma.<h4>Conclusion</h4>This meta-analysis suggested that both the IL-1B -511C/T and +3954C/T polymorphisms might modulate cancer susceptibility. Further well-designed studies based on larger sample sizes should be performed to confirm the findings.https://doi.org/10.1371/journal.pone.0063654 |
| spellingShingle | Jiali Xu Zhiqiang Yin Songyu Cao Wen Gao Lingxiang Liu Yongmei Yin Ping Liu Yongqian Shu Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk. PLoS ONE |
| title | Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk. |
| title_full | Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk. |
| title_fullStr | Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk. |
| title_full_unstemmed | Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk. |
| title_short | Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk. |
| title_sort | systematic review and meta analysis on the association between il 1b polymorphisms and cancer risk |
| url | https://doi.org/10.1371/journal.pone.0063654 |
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