Carcinogenic and anticancer activities of microbiota-derived secondary bile acids
Secondary bile acids (SBAs), which are metabolites produced by gut microbiota, have been implicated in both carcinogenic and anticancer processes. This review explores the dual role of SBAs, focusing on their molecular mechanisms and biological effects. The carcinogenic activities of SBAs include DN...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1514872/full |
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| author | Mobina Kouhzad Friedrich Götz Tahereh Navidifar Elahe Taki Mahsa Ghamari Roghayeh Mohammadzadeh Maryam Seyedolmohadesin Narjess Bostanghadiri |
| author_facet | Mobina Kouhzad Friedrich Götz Tahereh Navidifar Elahe Taki Mahsa Ghamari Roghayeh Mohammadzadeh Maryam Seyedolmohadesin Narjess Bostanghadiri |
| author_sort | Mobina Kouhzad |
| collection | DOAJ |
| description | Secondary bile acids (SBAs), which are metabolites produced by gut microbiota, have been implicated in both carcinogenic and anticancer processes. This review explores the dual role of SBAs, focusing on their molecular mechanisms and biological effects. The carcinogenic activities of SBAs include DNA damage, promotion of oxidative stress, and modulation of signaling pathways that drive tumorigenesis. Conversely, some SBAs exhibit anticancer properties by inducing apoptosis, inhibiting cell proliferation, and modulating immune responses. The article also discusses the complex interplay between SBAs and the host’s genetic and environmental factors, highlighting potential therapeutic implications and the need for targeted strategies to mitigate risks while harnessing beneficial effects. A comprehensive understanding of the delicate equilibrium between the deleterious and salutary impacts of SBAs has the potential to facilitate the development of innovative cancer prevention and treatment methodologies. |
| format | Article |
| id | doaj-art-5db64e328a4d413b8f21e3bbc0b15ce9 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-5db64e328a4d413b8f21e3bbc0b15ce92025-01-29T05:21:18ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.15148721514872Carcinogenic and anticancer activities of microbiota-derived secondary bile acidsMobina Kouhzad0Friedrich Götz1Tahereh Navidifar2Elahe Taki3Mahsa Ghamari4Roghayeh Mohammadzadeh5Maryam Seyedolmohadesin6Narjess Bostanghadiri7Department of Genetics, Faculty of Science, Islamic Azad University North Tehran Branch, Tehran, IranDepartment of Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, Tübingen, GermanyDepartment of Basic Sciences, Shoushtar Faculty of Medical Sciences, Shoushtar, IranDepartment of Microbiology, School of Medicine, Kermanshah University of Medical Science, Kermanshah, IranDepartment of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranDepartment of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Azad University, Tehran, IranResearch Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, IranSecondary bile acids (SBAs), which are metabolites produced by gut microbiota, have been implicated in both carcinogenic and anticancer processes. This review explores the dual role of SBAs, focusing on their molecular mechanisms and biological effects. The carcinogenic activities of SBAs include DNA damage, promotion of oxidative stress, and modulation of signaling pathways that drive tumorigenesis. Conversely, some SBAs exhibit anticancer properties by inducing apoptosis, inhibiting cell proliferation, and modulating immune responses. The article also discusses the complex interplay between SBAs and the host’s genetic and environmental factors, highlighting potential therapeutic implications and the need for targeted strategies to mitigate risks while harnessing beneficial effects. A comprehensive understanding of the delicate equilibrium between the deleterious and salutary impacts of SBAs has the potential to facilitate the development of innovative cancer prevention and treatment methodologies.https://www.frontiersin.org/articles/10.3389/fonc.2025.1514872/fullsecondary bile acidscarcinogenicanticancermicrobiotabile acids |
| spellingShingle | Mobina Kouhzad Friedrich Götz Tahereh Navidifar Elahe Taki Mahsa Ghamari Roghayeh Mohammadzadeh Maryam Seyedolmohadesin Narjess Bostanghadiri Carcinogenic and anticancer activities of microbiota-derived secondary bile acids Frontiers in Oncology secondary bile acids carcinogenic anticancer microbiota bile acids |
| title | Carcinogenic and anticancer activities of microbiota-derived secondary bile acids |
| title_full | Carcinogenic and anticancer activities of microbiota-derived secondary bile acids |
| title_fullStr | Carcinogenic and anticancer activities of microbiota-derived secondary bile acids |
| title_full_unstemmed | Carcinogenic and anticancer activities of microbiota-derived secondary bile acids |
| title_short | Carcinogenic and anticancer activities of microbiota-derived secondary bile acids |
| title_sort | carcinogenic and anticancer activities of microbiota derived secondary bile acids |
| topic | secondary bile acids carcinogenic anticancer microbiota bile acids |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1514872/full |
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