Cell-Based Strategies for Meniscus Tissue Engineering
Meniscus injuries remain a significant challenge due to the poor healing potential of the inner avascular zone. Following a series of studies and clinical trials, tissue engineering is considered a promising prospect for meniscus repair and regeneration. As one of the key factors in tissue engineeri...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/4717184 |
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| _version_ | 1832552773928878080 |
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| author | Wei Niu Weimin Guo Shufeng Han Yun Zhu Shuyun Liu Quanyi Guo |
| author_facet | Wei Niu Weimin Guo Shufeng Han Yun Zhu Shuyun Liu Quanyi Guo |
| author_sort | Wei Niu |
| collection | DOAJ |
| description | Meniscus injuries remain a significant challenge due to the poor healing potential of the inner avascular zone. Following a series of studies and clinical trials, tissue engineering is considered a promising prospect for meniscus repair and regeneration. As one of the key factors in tissue engineering, cells are believed to be highly beneficial in generating bionic meniscus structures to replace injured ones in patients. Therefore, cell-based strategies for meniscus tissue engineering play a fundamental role in meniscal regeneration. According to current studies, the main cell-based strategies for meniscus tissue engineering are single cell type strategies; cell coculture strategies also were applied to meniscus tissue engineering. Likewise, on the one side, the zonal recapitulation strategies based on mimicking meniscal differing cells and internal architectures have received wide attentions. On the other side, cell self-assembling strategies without any scaffolds may be a better way to build a bionic meniscus. In this review, we primarily discuss cell seeds for meniscus tissue engineering and their application strategies. We also discuss recent advances and achievements in meniscus repair experiments that further improve our understanding of meniscus tissue engineering. |
| format | Article |
| id | doaj-art-5db5472c18ef44f4b59315f3027c19d2 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5db5472c18ef44f4b59315f3027c19d22025-02-03T05:57:44ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/47171844717184Cell-Based Strategies for Meniscus Tissue EngineeringWei Niu0Weimin Guo1Shufeng Han2Yun Zhu3Shuyun Liu4Quanyi Guo5Beijing Key Laboratory of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaBeijing Key Laboratory of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, First Hospital of Shanxi Medical University, No. 85, Jiefang Nan Road, Yingze District, Taiyuan 030012, ChinaBeijing Key Laboratory of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaBeijing Key Laboratory of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaBeijing Key Laboratory of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaMeniscus injuries remain a significant challenge due to the poor healing potential of the inner avascular zone. Following a series of studies and clinical trials, tissue engineering is considered a promising prospect for meniscus repair and regeneration. As one of the key factors in tissue engineering, cells are believed to be highly beneficial in generating bionic meniscus structures to replace injured ones in patients. Therefore, cell-based strategies for meniscus tissue engineering play a fundamental role in meniscal regeneration. According to current studies, the main cell-based strategies for meniscus tissue engineering are single cell type strategies; cell coculture strategies also were applied to meniscus tissue engineering. Likewise, on the one side, the zonal recapitulation strategies based on mimicking meniscal differing cells and internal architectures have received wide attentions. On the other side, cell self-assembling strategies without any scaffolds may be a better way to build a bionic meniscus. In this review, we primarily discuss cell seeds for meniscus tissue engineering and their application strategies. We also discuss recent advances and achievements in meniscus repair experiments that further improve our understanding of meniscus tissue engineering.http://dx.doi.org/10.1155/2016/4717184 |
| spellingShingle | Wei Niu Weimin Guo Shufeng Han Yun Zhu Shuyun Liu Quanyi Guo Cell-Based Strategies for Meniscus Tissue Engineering Stem Cells International |
| title | Cell-Based Strategies for Meniscus Tissue Engineering |
| title_full | Cell-Based Strategies for Meniscus Tissue Engineering |
| title_fullStr | Cell-Based Strategies for Meniscus Tissue Engineering |
| title_full_unstemmed | Cell-Based Strategies for Meniscus Tissue Engineering |
| title_short | Cell-Based Strategies for Meniscus Tissue Engineering |
| title_sort | cell based strategies for meniscus tissue engineering |
| url | http://dx.doi.org/10.1155/2016/4717184 |
| work_keys_str_mv | AT weiniu cellbasedstrategiesformeniscustissueengineering AT weiminguo cellbasedstrategiesformeniscustissueengineering AT shufenghan cellbasedstrategiesformeniscustissueengineering AT yunzhu cellbasedstrategiesformeniscustissueengineering AT shuyunliu cellbasedstrategiesformeniscustissueengineering AT quanyiguo cellbasedstrategiesformeniscustissueengineering |