A Study of Clinical and Laboratory Profile of Fever with Thrombocytopenia
Background: Infections are the commonest cause of thrombocytopenia. Hence fever associated with thrombocytopenia helps to narrow down the differential diagnosis to infectious causes, plan manage-ment and anticipate complications Aim: The objective is to identify the possible infectious caus...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sri Devaraj Urs Academy of Higher Education and Research
2016-12-01
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| Series: | Journal of Clinical and Biomedical Sciences |
| Online Access: | https://jcbsonline.ac.in/articles/a-study-of-clinical-and-laboratory-profile-of-fever-with-thrombocytopenia |
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| Summary: | Background: Infections are the commonest cause of thrombocytopenia. Hence fever associated with thrombocytopenia helps to narrow down the differential diagnosis to infectious causes, plan manage-ment and anticipate complications Aim: The objective is to identify the possible infectious causes of fever with thrombocytopenia and to study the clinical profile and complications of such patients. Materials and Methods: This is a prospective study of 100 patients admitted with fever and thrombocytopenia in a medi-cal college hospital. The clinical profile, infectious causes, outcome and laboratory features are studied. Results: Dengue (47%) was the most commonest infectious cause among the patients with fever and thrombocytopenia followed by septicaemia and malaria. Bleeding manifestations were observed in 44% of the patients. Petechial rashes or purpura were the commonest haemorrhagic manifestation (66%) and spontaneous bleeding in the rest of them (34%). Majority of those with spontaneous bleeding had plate-let count of <30000/μl. The mortality rate among the series of patients was 11% and septicaemia account-ed for 72% followed by malaria in 18%. Conclusion: Dengue is the commonest infectious disease among patients hospitalised with fever and thrombocytopenia. Keywords: Dengue, thrombocytopenia, spontaneous bleeding, febrile illness |
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| ISSN: | 2231-4180 2319-2453 |