Therapeutic potential and mechanistic insights of astragaloside IV in the treatment of arrhythmia: a comprehensive review
Arrhythmia, a common cardiovascular disorder, results from disturbances in cardiac impulse generation and conduction, leading to decreased cardiac output and myocardial oxygenation, with potentially life-threatening consequences. Despite advancements in therapeutic approaches, the incidence and mort...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1528208/full |
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| author | Meilian Chen Binlan Fu Hao Zhou Qiaomin Wu |
| author_facet | Meilian Chen Binlan Fu Hao Zhou Qiaomin Wu |
| author_sort | Meilian Chen |
| collection | DOAJ |
| description | Arrhythmia, a common cardiovascular disorder, results from disturbances in cardiac impulse generation and conduction, leading to decreased cardiac output and myocardial oxygenation, with potentially life-threatening consequences. Despite advancements in therapeutic approaches, the incidence and mortality associated with arrhythmia remain high, and drug-related adverse effects continue to pose significant challenges. Traditional Chinese Medicine (TCM) has attracted considerable attention for its potential as a complementary and alternative approach in treating cardiovascular diseases, including arrhythmia. Astragalus, a prominent herb in TCM, is commonly used in clinical practice for its multi-faceted therapeutic properties, encompassing anti-arrhythmic, cardiotonic, anti-inflammatory, and immunomodulatory effects. Astragaloside IV, a primary active compound in Astragalus membranaceus, has demonstrated cardioprotective effects through mechanisms such as antioxidant, anti-inflammatory, and anti-apoptotic activities. Although evidence suggests that astragaloside IV holds promise in arrhythmia treatment, comprehensive reviews of its specific mechanisms and clinical applications in arrhythmia are scarce. This review systematically explores the pharmacological properties and underlying mechanisms of astragaloside IV in arrhythmia treatment. Utilizing a targeted search of databases including PubMed, Web of Science, Cochrane Library, Embase, CNKI, and Wanfang Data, we summarize recent findings and examine astragaloside IV’s potential applications in arrhythmia prevention and treatment. Our analysis aims to provide a theoretical foundation for the development of novel arrhythmia treatment strategies, while offering insights into future research directions for clinical application. |
| format | Article |
| id | doaj-art-5db4bd8728eb44139a20fa9f163f44cf |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj-art-5db4bd8728eb44139a20fa9f163f44cf2025-08-20T02:16:50ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-04-011610.3389/fphar.2025.15282081528208Therapeutic potential and mechanistic insights of astragaloside IV in the treatment of arrhythmia: a comprehensive reviewMeilian Chen0Binlan Fu1Hao Zhou2Qiaomin Wu3Cardiac and Pulmonary Department, Quanzhou Hospital of Traditional Chinese Medicine, Fujian, ChinaDepartment of Internal Medicine, Chen Dai Central Health Center, Jinjiang, ChinaDepartment of Cardiology, The 966th Hospital of The PLA Joint Logistic Support Force, Dandong, ChinaDepartment of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaArrhythmia, a common cardiovascular disorder, results from disturbances in cardiac impulse generation and conduction, leading to decreased cardiac output and myocardial oxygenation, with potentially life-threatening consequences. Despite advancements in therapeutic approaches, the incidence and mortality associated with arrhythmia remain high, and drug-related adverse effects continue to pose significant challenges. Traditional Chinese Medicine (TCM) has attracted considerable attention for its potential as a complementary and alternative approach in treating cardiovascular diseases, including arrhythmia. Astragalus, a prominent herb in TCM, is commonly used in clinical practice for its multi-faceted therapeutic properties, encompassing anti-arrhythmic, cardiotonic, anti-inflammatory, and immunomodulatory effects. Astragaloside IV, a primary active compound in Astragalus membranaceus, has demonstrated cardioprotective effects through mechanisms such as antioxidant, anti-inflammatory, and anti-apoptotic activities. Although evidence suggests that astragaloside IV holds promise in arrhythmia treatment, comprehensive reviews of its specific mechanisms and clinical applications in arrhythmia are scarce. This review systematically explores the pharmacological properties and underlying mechanisms of astragaloside IV in arrhythmia treatment. Utilizing a targeted search of databases including PubMed, Web of Science, Cochrane Library, Embase, CNKI, and Wanfang Data, we summarize recent findings and examine astragaloside IV’s potential applications in arrhythmia prevention and treatment. Our analysis aims to provide a theoretical foundation for the development of novel arrhythmia treatment strategies, while offering insights into future research directions for clinical application.https://www.frontiersin.org/articles/10.3389/fphar.2025.1528208/fullarrhythmiaastragaloside IVtraditional Chinese medicineAstragalus membranaceuspharmacological mechanisms |
| spellingShingle | Meilian Chen Binlan Fu Hao Zhou Qiaomin Wu Therapeutic potential and mechanistic insights of astragaloside IV in the treatment of arrhythmia: a comprehensive review Frontiers in Pharmacology arrhythmia astragaloside IV traditional Chinese medicine Astragalus membranaceus pharmacological mechanisms |
| title | Therapeutic potential and mechanistic insights of astragaloside IV in the treatment of arrhythmia: a comprehensive review |
| title_full | Therapeutic potential and mechanistic insights of astragaloside IV in the treatment of arrhythmia: a comprehensive review |
| title_fullStr | Therapeutic potential and mechanistic insights of astragaloside IV in the treatment of arrhythmia: a comprehensive review |
| title_full_unstemmed | Therapeutic potential and mechanistic insights of astragaloside IV in the treatment of arrhythmia: a comprehensive review |
| title_short | Therapeutic potential and mechanistic insights of astragaloside IV in the treatment of arrhythmia: a comprehensive review |
| title_sort | therapeutic potential and mechanistic insights of astragaloside iv in the treatment of arrhythmia a comprehensive review |
| topic | arrhythmia astragaloside IV traditional Chinese medicine Astragalus membranaceus pharmacological mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1528208/full |
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