Bottlenecks of Immune Checkpoint Inhibitors in Treatment of Gastrointestinal Tumors
Immune checkpoint inhibitors (ICIs), as one of relatively advanced antitumor treatment methods in recent years, have achieved significant therapeutic effects in the treatment of multiple systemic tumors. However, their application in gastrointestinal tumors is not satisfactory, with treatment bottle...
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| Format: | Article |
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Magazine House of Cancer Research on Prevention and Treatment
2025-07-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.1051 |
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| author | Chun HAN Li BAI |
| author_facet | Chun HAN Li BAI |
| author_sort | Chun HAN |
| collection | DOAJ |
| description | Immune checkpoint inhibitors (ICIs), as one of relatively advanced antitumor treatment methods in recent years, have achieved significant therapeutic effects in the treatment of multiple systemic tumors. However, their application in gastrointestinal tumors is not satisfactory, with treatment bottlenecks. This article summarizes the challenges and possible solutions faced by ICIs in the treatment of gastrointestinal tumors to help clinicians better understand the limitations and future development directions of ICIs and thus develop more effective treatment strategies. |
| format | Article |
| id | doaj-art-5db0a6d92aa74b779d202ba726923b14 |
| institution | DOAJ |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2025-07-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-5db0a6d92aa74b779d202ba726923b142025-08-20T02:45:41ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782025-07-0152753954710.3971/j.issn.1000-8578.2025.24.105120241051Bottlenecks of Immune Checkpoint Inhibitors in Treatment of Gastrointestinal TumorsChun HAN0Li BAI1Outpatient Chemotherapy Center, Beijing Arion Cancer Center, Beijing 102600, ChinaDepartment of Oncology, First Medical Center, General Hospital of Chinese People’s Liberation Army (PLA), Beijing 100853, ChinaImmune checkpoint inhibitors (ICIs), as one of relatively advanced antitumor treatment methods in recent years, have achieved significant therapeutic effects in the treatment of multiple systemic tumors. However, their application in gastrointestinal tumors is not satisfactory, with treatment bottlenecks. This article summarizes the challenges and possible solutions faced by ICIs in the treatment of gastrointestinal tumors to help clinicians better understand the limitations and future development directions of ICIs and thus develop more effective treatment strategies.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.1051icisgastrointestinal tumorstumor microenvironment (tme)inflammationgut microbiota |
| spellingShingle | Chun HAN Li BAI Bottlenecks of Immune Checkpoint Inhibitors in Treatment of Gastrointestinal Tumors Zhongliu Fangzhi Yanjiu icis gastrointestinal tumors tumor microenvironment (tme) inflammation gut microbiota |
| title | Bottlenecks of Immune Checkpoint Inhibitors in Treatment of Gastrointestinal Tumors |
| title_full | Bottlenecks of Immune Checkpoint Inhibitors in Treatment of Gastrointestinal Tumors |
| title_fullStr | Bottlenecks of Immune Checkpoint Inhibitors in Treatment of Gastrointestinal Tumors |
| title_full_unstemmed | Bottlenecks of Immune Checkpoint Inhibitors in Treatment of Gastrointestinal Tumors |
| title_short | Bottlenecks of Immune Checkpoint Inhibitors in Treatment of Gastrointestinal Tumors |
| title_sort | bottlenecks of immune checkpoint inhibitors in treatment of gastrointestinal tumors |
| topic | icis gastrointestinal tumors tumor microenvironment (tme) inflammation gut microbiota |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.1051 |
| work_keys_str_mv | AT chunhan bottlenecksofimmunecheckpointinhibitorsintreatmentofgastrointestinaltumors AT libai bottlenecksofimmunecheckpointinhibitorsintreatmentofgastrointestinaltumors |