Expression levels of β1, β3 integrins and MMP2 and features of morphological heterogeneity of pancreatic ductal adenocarcinoma associated with distant metastasis

Expression levels of β1, β3 integrins and MMP2 and features of morphological heterogeneity of pancreatic ductal adenocarcinoma associated with distant metastasis

Background. Pancreatic cancer is characterized by pronounced invasive growth and a high tendency to lymphogenous and hematogenous metastasis. Molecular mechanisms underlying the epithelial-mesenchymal transition, in particular, changes in the expression of β1, β3 integrins and MMP2, contribute to th...

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Bibliographic Details
Main Authors: Yu. Yu. Rakina, N. V. Krakhmal, D. S. Pismenny, A. V. Zavyalov, S. V. Vtorushin, S. G. Afanasyev, M. V. Zavyalova
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Tomsk National Research Medical Center 2023-05-01
Series:Сибирский онкологический журнал
Subjects:
ductal pancreatic adenocarcinoma
β1 integrin
β3 integrin
mmp2
tumor morphological heterogeneity
distant metastases
Online Access:https://www.siboncoj.ru/jour/article/view/2538
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