The Physiological Role of Mitophagy: New Insights into Phosphorylation Events
Mitochondria play an essential role in oxidative phosphorylation, fatty acid oxidation, and the regulation of apoptosis. However, this organelle also produces reactive oxygen species (ROS) that continually inflict oxidative damage on mitochondrial DNA, proteins, and lipids, which causes further prod...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/354914 |
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| _version_ | 1850223260603514880 |
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| author | Yuko Hirota Dongchon Kang Tomotake Kanki |
| author_facet | Yuko Hirota Dongchon Kang Tomotake Kanki |
| author_sort | Yuko Hirota |
| collection | DOAJ |
| description | Mitochondria play an essential role in oxidative phosphorylation, fatty acid oxidation, and the regulation of apoptosis. However, this organelle also produces reactive oxygen species (ROS) that continually inflict oxidative damage on mitochondrial DNA, proteins, and lipids, which causes further production of ROS. To oppose this oxidative stress, mitochondria possess quality control systems that include antioxidant enzymes and the repair or degradation of damaged mitochondrial DNA and proteins. If the oxidative stress exceeds the capacity of the mitochondrial quality control system, it seems that autophagy degrades the damaged mitochondria to maintain cellular homeostasis. Indeed, recent evidence from yeast to mammals indicates that the autophagy-dependent degradation of mitochondria (mitophagy) contributes to eliminate dysfunctional, aged, or excess mitochondria. In this paper, we describe the molecular processes and regulatory mechanisms of mitophagy in yeast and mammalian cells. |
| format | Article |
| id | doaj-art-5dad2f25396040eebcef045aab1eab6f |
| institution | OA Journals |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-5dad2f25396040eebcef045aab1eab6f2025-08-20T02:06:01ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/354914354914The Physiological Role of Mitophagy: New Insights into Phosphorylation EventsYuko Hirota0Dongchon Kang1Tomotake Kanki2Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JapanDepartment of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JapanDepartment of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JapanMitochondria play an essential role in oxidative phosphorylation, fatty acid oxidation, and the regulation of apoptosis. However, this organelle also produces reactive oxygen species (ROS) that continually inflict oxidative damage on mitochondrial DNA, proteins, and lipids, which causes further production of ROS. To oppose this oxidative stress, mitochondria possess quality control systems that include antioxidant enzymes and the repair or degradation of damaged mitochondrial DNA and proteins. If the oxidative stress exceeds the capacity of the mitochondrial quality control system, it seems that autophagy degrades the damaged mitochondria to maintain cellular homeostasis. Indeed, recent evidence from yeast to mammals indicates that the autophagy-dependent degradation of mitochondria (mitophagy) contributes to eliminate dysfunctional, aged, or excess mitochondria. In this paper, we describe the molecular processes and regulatory mechanisms of mitophagy in yeast and mammalian cells.http://dx.doi.org/10.1155/2012/354914 |
| spellingShingle | Yuko Hirota Dongchon Kang Tomotake Kanki The Physiological Role of Mitophagy: New Insights into Phosphorylation Events International Journal of Cell Biology |
| title | The Physiological Role of Mitophagy: New Insights into Phosphorylation Events |
| title_full | The Physiological Role of Mitophagy: New Insights into Phosphorylation Events |
| title_fullStr | The Physiological Role of Mitophagy: New Insights into Phosphorylation Events |
| title_full_unstemmed | The Physiological Role of Mitophagy: New Insights into Phosphorylation Events |
| title_short | The Physiological Role of Mitophagy: New Insights into Phosphorylation Events |
| title_sort | physiological role of mitophagy new insights into phosphorylation events |
| url | http://dx.doi.org/10.1155/2012/354914 |
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