A matters arising: discussion on urokinase dosing and individualized treatment strategies in the TRUST trial
Abstract This matters arising addresses the recently published article in BMC Medicine by Tao Y et al., entitled “Effect of intravenous urokinase vs best medicine treatment on functional outcome for patients with acute minor stroke (TRUST): a randomized controlled trial.” While appreciating the rigo...
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BMC
2025-05-01
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| Series: | BMC Medicine |
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| Online Access: | https://doi.org/10.1186/s12916-025-04151-6 |
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| author | Yue Qiao Xunming Ji Wenbo Zhao |
| author_facet | Yue Qiao Xunming Ji Wenbo Zhao |
| author_sort | Yue Qiao |
| collection | DOAJ |
| description | Abstract This matters arising addresses the recently published article in BMC Medicine by Tao Y et al., entitled “Effect of intravenous urokinase vs best medicine treatment on functional outcome for patients with acute minor stroke (TRUST): a randomized controlled trial.” While appreciating the rigorous methodology and important findings of the TRUST trial, we raise several points regarding optimizing urokinase dosing and treatment strategies. Specifically, we discuss the potential for optimizing urokinase dosing based on emerging evidence. Given China’s extensive clinical experience with urokinase and associated cost considerations, we advocate for further research, including trials evaluating weight-based dosing strategies, to optimize urokinase thrombolytic therapy for patients with acute ischemic stroke. Such research is crucial for optimizing urokinase thrombolysis and establishing its role as a cost-effective treatment option, especially in resource-limited settings. |
| format | Article |
| id | doaj-art-5da8e3be42dd46c387ea5506fce710d2 |
| institution | OA Journals |
| issn | 1741-7015 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj-art-5da8e3be42dd46c387ea5506fce710d22025-08-20T01:59:57ZengBMCBMC Medicine1741-70152025-05-012311310.1186/s12916-025-04151-6A matters arising: discussion on urokinase dosing and individualized treatment strategies in the TRUST trialYue Qiao0Xunming Ji1Wenbo Zhao2Department of Neurology, Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityAbstract This matters arising addresses the recently published article in BMC Medicine by Tao Y et al., entitled “Effect of intravenous urokinase vs best medicine treatment on functional outcome for patients with acute minor stroke (TRUST): a randomized controlled trial.” While appreciating the rigorous methodology and important findings of the TRUST trial, we raise several points regarding optimizing urokinase dosing and treatment strategies. Specifically, we discuss the potential for optimizing urokinase dosing based on emerging evidence. Given China’s extensive clinical experience with urokinase and associated cost considerations, we advocate for further research, including trials evaluating weight-based dosing strategies, to optimize urokinase thrombolytic therapy for patients with acute ischemic stroke. Such research is crucial for optimizing urokinase thrombolysis and establishing its role as a cost-effective treatment option, especially in resource-limited settings.https://doi.org/10.1186/s12916-025-04151-6Acute ischemic strokeIntravenous thrombolysisUrokinaseTRUST trial |
| spellingShingle | Yue Qiao Xunming Ji Wenbo Zhao A matters arising: discussion on urokinase dosing and individualized treatment strategies in the TRUST trial BMC Medicine Acute ischemic stroke Intravenous thrombolysis Urokinase TRUST trial |
| title | A matters arising: discussion on urokinase dosing and individualized treatment strategies in the TRUST trial |
| title_full | A matters arising: discussion on urokinase dosing and individualized treatment strategies in the TRUST trial |
| title_fullStr | A matters arising: discussion on urokinase dosing and individualized treatment strategies in the TRUST trial |
| title_full_unstemmed | A matters arising: discussion on urokinase dosing and individualized treatment strategies in the TRUST trial |
| title_short | A matters arising: discussion on urokinase dosing and individualized treatment strategies in the TRUST trial |
| title_sort | matters arising discussion on urokinase dosing and individualized treatment strategies in the trust trial |
| topic | Acute ischemic stroke Intravenous thrombolysis Urokinase TRUST trial |
| url | https://doi.org/10.1186/s12916-025-04151-6 |
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