Mefloquine reduces the bacterial membrane fluidity of Acinetobacter baumannii and distorts the bacterial membrane when combined with polymyxin B

Mefloquine reduces the bacterial membrane fluidity of Acinetobacter baumannii and distorts the bacterial membrane when combined with polymyxin B

ABSTRACT Acinetobacter baumannii is a high-priority organism for the development of new antibacterial treatments. We found that the antimalarial medication mefloquine (MFQ) permeabilized the bacterial cell membrane of A. baumannii, decreased membrane fluidity, and caused physical injury to the membr...

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Bibliographic Details
Main Authors: Nagendran Tharmalingam, Harikrishna Sekar Jayanthan, Jenna Port, Fernanda Cristina Possamai Rossatto, Eleftherios Mylonakis
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
A. baumannii
antibiotic resistance
mefloquine
polymyxin
synergy
Online Access:https://journals.asm.org/doi/10.1128/mbio.04016-24
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