Myocardial revascularization effects on vascular endothelial growth factor and transforming growth factor β-1 in coronary heart disease patients
Aim. To assess the dynamics of vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF- 1) and VEGF receptor Flt-1 (sFlt-1 or sVEGF-R1) levels in coronary heart disease (CHD) patients before and after myocardial revascularization. Material and methods: We examined fasting ser...
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| Format: | Article |
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«SILICEA-POLIGRAF» LLC
2007-10-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1317 |
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| author | I. V. Sergienko A. E. Semenova V. P. Masenko L. I. Habibullina S. A. Gabrusenko V. V. Kukharchuk Yu. N. Belenkov |
| author_facet | I. V. Sergienko A. E. Semenova V. P. Masenko L. I. Habibullina S. A. Gabrusenko V. V. Kukharchuk Yu. N. Belenkov |
| author_sort | I. V. Sergienko |
| collection | DOAJ |
| description | Aim. To assess the dynamics of vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF- 1) and VEGF receptor Flt-1 (sFlt-1 or sVEGF-R1) levels in coronary heart disease (CHD) patients before and after myocardial revascularization. Material and methods: We examined fasting serum VEGF, TGF-β1 and sVEGF-R1 concentrations in 40 CHD patients (main group) 1 day before and 6 days after successful myocardial revascularization (percutaneous coronary intervention, PCI – 75%; grafting bypass surgery – 25%). Control group included 30 healthy volunteers, with fasting blood samples taken once. Results: Serum levels of VEGF and TGF-β1 in controls were 166,9±96,9 and 120±32,4 pg/ml, respectively. Before myocardial revascularization in CHD patients, VEGF level was 192,4±166,1 pg/ml, and TGF-β1 level was 11±4,9 pg/ml. There was no significant difference in basic serum levels of VEGF (p=0,4), but TGF-β1 levels were significantly lower in CHD patients, comparing to controls (р<0,0001). sVEGF-R1 levels were very low in main (0,3 pg/ml) and control (0,2 pg/ml) groups (р>0,05). After myocardial revascularization, the levels of VEGF, TGF-β1 and sVEGF-R1 were 264,7±226,6, 11,7±4,9, and 0,2 pg/ml, respectively. There was a significant increase in VEGF levels (р=0,066), without any substantial changes in TGF-β1 (р>0,05) and sVEGF-R1 (р>0,05) levels 6 days after revascularization. VEGF level reduction was observed in 6 out of 30 (20%) patients after PCI and in 2 out of 10 (20%) patients after grafting bypass surgery. In the other cases, post5revascularization VEGF level increased significantly, due to intra-revascularization transient myocardial ischemia. Conclusion: Myocardial ischemia increased VEGF levels and decreased TGF-β1 levels, not affecting sVEGF-R1 concentration. |
| format | Article |
| id | doaj-art-5da40de779c74ad1af2fd0f92e08dbf6 |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2007-10-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-5da40de779c74ad1af2fd0f92e08dbf62025-08-20T03:57:09Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252007-10-016512171027Myocardial revascularization effects on vascular endothelial growth factor and transforming growth factor β-1 in coronary heart disease patientsI. V. Sergienko0A. E. Semenova1V. P. Masenko2L. I. Habibullina3S. A. Gabrusenko4V. V. Kukharchuk5Yu. N. Belenkov6Russian Cardiology Scientific and Clinical Complex, State Federal Agency for Health and Social Development, MoscowRussian Cardiology Scientific and Clinical Complex, State Federal Agency for Health and Social Development, MoscowRussian Cardiology Scientific and Clinical Complex, State Federal Agency for Health and Social Development, MoscowRussian Cardiology Scientific and Clinical Complex, State Federal Agency for Health and Social Development, MoscowRussian Cardiology Scientific and Clinical Complex, State Federal Agency for Health and Social Development, MoscowRussian Cardiology Scientific and Clinical Complex, State Federal Agency for Health and Social Development, MoscowRussian Cardiology Scientific and Clinical Complex, State Federal Agency for Health and Social Development, MoscowAim. To assess the dynamics of vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF- 1) and VEGF receptor Flt-1 (sFlt-1 or sVEGF-R1) levels in coronary heart disease (CHD) patients before and after myocardial revascularization. Material and methods: We examined fasting serum VEGF, TGF-β1 and sVEGF-R1 concentrations in 40 CHD patients (main group) 1 day before and 6 days after successful myocardial revascularization (percutaneous coronary intervention, PCI – 75%; grafting bypass surgery – 25%). Control group included 30 healthy volunteers, with fasting blood samples taken once. Results: Serum levels of VEGF and TGF-β1 in controls were 166,9±96,9 and 120±32,4 pg/ml, respectively. Before myocardial revascularization in CHD patients, VEGF level was 192,4±166,1 pg/ml, and TGF-β1 level was 11±4,9 pg/ml. There was no significant difference in basic serum levels of VEGF (p=0,4), but TGF-β1 levels were significantly lower in CHD patients, comparing to controls (р<0,0001). sVEGF-R1 levels were very low in main (0,3 pg/ml) and control (0,2 pg/ml) groups (р>0,05). After myocardial revascularization, the levels of VEGF, TGF-β1 and sVEGF-R1 were 264,7±226,6, 11,7±4,9, and 0,2 pg/ml, respectively. There was a significant increase in VEGF levels (р=0,066), without any substantial changes in TGF-β1 (р>0,05) and sVEGF-R1 (р>0,05) levels 6 days after revascularization. VEGF level reduction was observed in 6 out of 30 (20%) patients after PCI and in 2 out of 10 (20%) patients after grafting bypass surgery. In the other cases, post5revascularization VEGF level increased significantly, due to intra-revascularization transient myocardial ischemia. Conclusion: Myocardial ischemia increased VEGF levels and decreased TGF-β1 levels, not affecting sVEGF-R1 concentration.https://cardiovascular.elpub.ru/jour/article/view/1317vascular endothelial growth factortransforming growth factor-beta1myocardial ischemiamyocardial revascularizationcoronary heart disease |
| spellingShingle | I. V. Sergienko A. E. Semenova V. P. Masenko L. I. Habibullina S. A. Gabrusenko V. V. Kukharchuk Yu. N. Belenkov Myocardial revascularization effects on vascular endothelial growth factor and transforming growth factor β-1 in coronary heart disease patients Кардиоваскулярная терапия и профилактика vascular endothelial growth factor transforming growth factor-beta1 myocardial ischemia myocardial revascularization coronary heart disease |
| title | Myocardial revascularization effects on vascular endothelial growth factor and transforming growth factor β-1 in coronary heart disease patients |
| title_full | Myocardial revascularization effects on vascular endothelial growth factor and transforming growth factor β-1 in coronary heart disease patients |
| title_fullStr | Myocardial revascularization effects on vascular endothelial growth factor and transforming growth factor β-1 in coronary heart disease patients |
| title_full_unstemmed | Myocardial revascularization effects on vascular endothelial growth factor and transforming growth factor β-1 in coronary heart disease patients |
| title_short | Myocardial revascularization effects on vascular endothelial growth factor and transforming growth factor β-1 in coronary heart disease patients |
| title_sort | myocardial revascularization effects on vascular endothelial growth factor and transforming growth factor β 1 in coronary heart disease patients |
| topic | vascular endothelial growth factor transforming growth factor-beta1 myocardial ischemia myocardial revascularization coronary heart disease |
| url | https://cardiovascular.elpub.ru/jour/article/view/1317 |
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